Pre-Processing a Polymer Blend into a Polymer Alloy by KinetiSol Enables Increased Ivacaftor Amorphous Solid Dispersion Drug Loading and Dissolution

Pre-Processing a Polymer Blend into a Polymer Alloy by KinetiSol Enables Increased Ivacaftor Amorphous Solid Dispersion Drug Loading and Dissolution

This study compares the effects of pre-processing multiple polymers together to form a single-phase polymer alloy prior to amorphous solid dispersion formulation. KinetiSol compounding was used to pre-process a 1:1 (<i>w</i>/<i>w</i>) ratio of hypromellose acetate succinate a...

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Bibliographic Details
Main Authors: Stephen A. Thompson, Daniel A. Davis, Dave A. Miller, Sandra U. Kucera, Robert O. Williams
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Biomedicines
Subjects:
ivacaftor
amorphous solid dispersion
polymer
polymer alloy
drug loading
Kalydeco
Online Access:https://www.mdpi.com/2227-9059/11/5/1281

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