Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy
Abstract Sonodynamic therapy (SDT) has been widely reported as a noninvasive and high‐penetration therapy for cancer; however, the design of an efficient sonosensitizer remains an urgent need. To address this issue, molybdenum disulfide nanoflowers (MoS2 NF) as piezo‐sonosensitizers and introduced s...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-09-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202301152 |
| _version_ | 1797684963126018048 |
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| author | Qingyuan Wu Jie Zhang Xueting Pan Zhijun Huang Haoyuan Zhang Juan Guo Yun Xue Rui Shi Huiyu Liu |
| author_facet | Qingyuan Wu Jie Zhang Xueting Pan Zhijun Huang Haoyuan Zhang Juan Guo Yun Xue Rui Shi Huiyu Liu |
| author_sort | Qingyuan Wu |
| collection | DOAJ |
| description | Abstract Sonodynamic therapy (SDT) has been widely reported as a noninvasive and high‐penetration therapy for cancer; however, the design of an efficient sonosensitizer remains an urgent need. To address this issue, molybdenum disulfide nanoflowers (MoS2 NF) as piezo‐sonosensitizers and introduced sulfur vacancies on the MoS2 NF (Sv‐MoS2 NF) to improve their piezoelectric property for cancer therapy are designed. Under ultrasonic mechanical stress, the Sv‐MoS2 NF resulted in piezoelectric polarization and band tilting, which enhanced the charge carrier separation and migration. This resulted in an improved catalytic reaction for reactive oxygen species (ROS) production, ultimately enhancing the SDT performance. Thanks to the high efficiency of ROS generation, the Sv‐MoS2 NF have demonstrated a good anticancer effect in vitro and in vivo. Following a systematic evaluation, Sv‐MoS2 NF also demonstrated good biocompatibility. This novel piezo‐sonosensitizer and vacancy engineering strategy provides a promising new approach for achieving efficient SDT. |
| first_indexed | 2024-03-12T00:37:26Z |
| format | Article |
| id | doaj.art-b768602b3c80421992e7ef659073cdfc |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-12T00:37:26Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-b768602b3c80421992e7ef659073cdfc2023-09-15T09:28:59ZengWileyAdvanced Science2198-38442023-09-011026n/an/a10.1002/advs.202301152Vacancy Augmented Piezo‐Sonosensitizer for Cancer TherapyQingyuan Wu0Jie Zhang1Xueting Pan2Zhijun Huang3Haoyuan Zhang4Juan Guo5Yun Xue6Rui Shi7Huiyu Liu8Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic‐Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing University of Chemical Technology Beijing 100029 P. R. ChinaBeijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic‐Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing University of Chemical Technology Beijing 100029 P. R. ChinaBeijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic‐Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing University of Chemical Technology Beijing 100029 P. R. ChinaBeijing National Laboratory of Molecular Sciences, Beijing National Laboratory of Molecular Sciences Institute of Chemistry, Chinese Academy of Sciences Beijing 100190 P. R. ChinaBeijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic‐Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing University of Chemical Technology Beijing 100029 P. R. ChinaBeijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic‐Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing University of Chemical Technology Beijing 100029 P. R. ChinaNational Center for Orthopaedics Beijing Research Institute of Traumatology and Orthopaedics Beijing Jishuitan Hospital Beijing 100035 P. R. ChinaNational Center for Orthopaedics Beijing Research Institute of Traumatology and Orthopaedics Beijing Jishuitan Hospital Beijing 100035 P. R. ChinaBeijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic‐Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing University of Chemical Technology Beijing 100029 P. R. ChinaAbstract Sonodynamic therapy (SDT) has been widely reported as a noninvasive and high‐penetration therapy for cancer; however, the design of an efficient sonosensitizer remains an urgent need. To address this issue, molybdenum disulfide nanoflowers (MoS2 NF) as piezo‐sonosensitizers and introduced sulfur vacancies on the MoS2 NF (Sv‐MoS2 NF) to improve their piezoelectric property for cancer therapy are designed. Under ultrasonic mechanical stress, the Sv‐MoS2 NF resulted in piezoelectric polarization and band tilting, which enhanced the charge carrier separation and migration. This resulted in an improved catalytic reaction for reactive oxygen species (ROS) production, ultimately enhancing the SDT performance. Thanks to the high efficiency of ROS generation, the Sv‐MoS2 NF have demonstrated a good anticancer effect in vitro and in vivo. Following a systematic evaluation, Sv‐MoS2 NF also demonstrated good biocompatibility. This novel piezo‐sonosensitizer and vacancy engineering strategy provides a promising new approach for achieving efficient SDT.https://doi.org/10.1002/advs.202301152molybdenum disulfidepiezoelectricitysonodynamic therapyultrasoundvacancy |
| spellingShingle | Qingyuan Wu Jie Zhang Xueting Pan Zhijun Huang Haoyuan Zhang Juan Guo Yun Xue Rui Shi Huiyu Liu Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy Advanced Science molybdenum disulfide piezoelectricity sonodynamic therapy ultrasound vacancy |
| title | Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy |
| title_full | Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy |
| title_fullStr | Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy |
| title_full_unstemmed | Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy |
| title_short | Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy |
| title_sort | vacancy augmented piezo sonosensitizer for cancer therapy |
| topic | molybdenum disulfide piezoelectricity sonodynamic therapy ultrasound vacancy |
| url | https://doi.org/10.1002/advs.202301152 |
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