Zein as a renewable material for the preparation of green nanoparticles for drug delivery
Environmental sustainability is a key challenge driven by the increased consumption of natural resources with limited availability. In this scenario agriculture has emerged as a privileged source of renewable resources, hence more efforts should be addressed to the study of plant-derived materials f...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Biomaterials Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbiom.2023.1156403/full |
| _version_ | 1827613329254776832 |
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| author | Francesca Tivano Francesca Tivano Francesca Tivano Valeria Chiono Valeria Chiono Valeria Chiono Valeria Chiono |
| author_facet | Francesca Tivano Francesca Tivano Francesca Tivano Valeria Chiono Valeria Chiono Valeria Chiono Valeria Chiono |
| author_sort | Francesca Tivano |
| collection | DOAJ |
| description | Environmental sustainability is a key challenge driven by the increased consumption of natural resources with limited availability. In this scenario agriculture has emerged as a privileged source of renewable resources, hence more efforts should be addressed to the study of plant-derived materials for medical applications. Zein is a biocompatible, biodegradable and amphiphilic prolamin protein extracted from the endosperm tissue of corn. For these reasons, its applications span from coatings for edible capsules, to the fabrication of bi- and tridimensional scaffolds for tissue engineering, and to develop drug delivery systems. This review aims at describing the properties and main applications of zein with a focus on the most recent and updated state of the art literature on zein based nanoparticles for the controlled delivery of various drugs. The main focus is to analyze the state of the art literature to understand how to implement sustainable methods for the preparation of zein NPs and to propose their exploitation as novel drug delivery systems for multiple applications, including oligonucleotide delivery. Main methods for zein NP preparation are described under an ecofriendly point of view, highlighting their environmental sustainability based on used solvents, waste products and energy consumption. |
| first_indexed | 2024-03-09T08:37:09Z |
| format | Article |
| id | doaj.art-b76b550d0e9b426ab597dc566efa31b9 |
| institution | Directory Open Access Journal |
| issn | 2813-3749 |
| language | English |
| last_indexed | 2024-03-09T08:37:09Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Biomaterials Science |
| spelling | doaj.art-b76b550d0e9b426ab597dc566efa31b92023-12-02T17:54:51ZengFrontiers Media S.A.Frontiers in Biomaterials Science2813-37492023-05-01210.3389/fbiom.2023.11564031156403Zein as a renewable material for the preparation of green nanoparticles for drug deliveryFrancesca Tivano0Francesca Tivano1Francesca Tivano2Valeria Chiono3Valeria Chiono4Valeria Chiono5Valeria Chiono6Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Torino, ItalyPOLITO BioMedLab, Politecnico di Torino, Torino, Italy3R, Interuniversity Center for the Promotion of the 3Rs Principles in Teaching and Research, Torino, ItalyDepartment of Mechanical and Aerospace Engineering, Politecnico di Torino, Torino, ItalyPOLITO BioMedLab, Politecnico di Torino, Torino, Italy3R, Interuniversity Center for the Promotion of the 3Rs Principles in Teaching and Research, Torino, ItalyDepartment for Materials and Devices of the National Research Council, Institute for the Chemical and Physical Processes (CNR-IPCF UOS), Pisa, ItalyEnvironmental sustainability is a key challenge driven by the increased consumption of natural resources with limited availability. In this scenario agriculture has emerged as a privileged source of renewable resources, hence more efforts should be addressed to the study of plant-derived materials for medical applications. Zein is a biocompatible, biodegradable and amphiphilic prolamin protein extracted from the endosperm tissue of corn. For these reasons, its applications span from coatings for edible capsules, to the fabrication of bi- and tridimensional scaffolds for tissue engineering, and to develop drug delivery systems. This review aims at describing the properties and main applications of zein with a focus on the most recent and updated state of the art literature on zein based nanoparticles for the controlled delivery of various drugs. The main focus is to analyze the state of the art literature to understand how to implement sustainable methods for the preparation of zein NPs and to propose their exploitation as novel drug delivery systems for multiple applications, including oligonucleotide delivery. Main methods for zein NP preparation are described under an ecofriendly point of view, highlighting their environmental sustainability based on used solvents, waste products and energy consumption.https://www.frontiersin.org/articles/10.3389/fbiom.2023.1156403/fulldrug deliverygreen technologiesnanoparticleszeinsustainable materials |
| spellingShingle | Francesca Tivano Francesca Tivano Francesca Tivano Valeria Chiono Valeria Chiono Valeria Chiono Valeria Chiono Zein as a renewable material for the preparation of green nanoparticles for drug delivery Frontiers in Biomaterials Science drug delivery green technologies nanoparticles zein sustainable materials |
| title | Zein as a renewable material for the preparation of green nanoparticles for drug delivery |
| title_full | Zein as a renewable material for the preparation of green nanoparticles for drug delivery |
| title_fullStr | Zein as a renewable material for the preparation of green nanoparticles for drug delivery |
| title_full_unstemmed | Zein as a renewable material for the preparation of green nanoparticles for drug delivery |
| title_short | Zein as a renewable material for the preparation of green nanoparticles for drug delivery |
| title_sort | zein as a renewable material for the preparation of green nanoparticles for drug delivery |
| topic | drug delivery green technologies nanoparticles zein sustainable materials |
| url | https://www.frontiersin.org/articles/10.3389/fbiom.2023.1156403/full |
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