Prevalence of High and Low Level Mupirocin Resistance among Staphylococcal Isolates from Skin Infection in a Tertiary Care Hospital
ABSTRACT Background: Mupirocin has been used for the treatment of skin infections and for the eradication of the nasal carriage of Methicillin -resistant Staphylococcus aureus (MRSA). The increased use of this antibiotic has been accompanied by its resistance, resulting in treatment failures....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2013-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/2736/12-%204694_u.pdf |
| Summary: | ABSTRACT
Background: Mupirocin has been used for the treatment of
skin infections and for the eradication of the nasal carriage
of Methicillin -resistant Staphylococcus aureus (MRSA). The
increased use of this antibiotic has been accompanied by its
resistance, resulting in treatment failures.
Objective: This study was aimed at determining the prevalences
of low and high level Mupirocin resistance among the clinical
isolates of Staphylococcus species which were obtained from
pyogenic infections.
Material and Method: Clinical samples such as wound swabs,
tissues and pus which were submitted to the microbiology
laboratory during a period of six months were screened for the
growth of Staphylococcus species, which were identified as
Staphylococcus aureus and Coagulase negative Staphylococcus
species by the routine microbiological procedures. All the
isolates were tested for their Mupirocin susceptibilities by using
5 and 200 µg discs and their resistance was confirmed from
their Minimum Inhibitory Concentrations (MICs).
Result: Out of 400 samples, 150 samples grew Staphylococcus
species, of which 113 were Staphylococcus aureus and 37 were
Coagulase negative Staphylococcus (CoNS). Only 5(3.3%)
mupirocin resistant Staphylococcus species: three high level and
two low level strains were detected. The MICs for the two low
level and three high level Mupirocin resistant strains were 256
mg/L and ≥512mg/L each respectively.
Conclusion: We conclude that the screening for mupirocin
resistance, in terms of high-level and low-level resistance
among the Staphylococcus species from patients with skin and
soft tissue infections is warranted and that it is important for
the clinicians in selecting the appropriate, empirical, topical,
antimicrobial therapy. It also provides useful information about
the prevalence of these resistant pathogens. |
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| ISSN: | 2249-782X 0973-709X |