Intercepting IRE1 kinase‐FMRP signaling prevents atherosclerosis progression

Intercepting IRE1 kinase‐FMRP signaling prevents atherosclerosis progression

Abstract Fragile X Mental Retardation protein (FMRP), widely known for its role in hereditary intellectual disability, is an RNA‐binding protein (RBP) that controls translation of select mRNAs. We discovered that endoplasmic reticulum (ER) stress induces phosphorylation of FMRP on a site that is kno...

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Bibliographic Details
Main Authors: Zehra Yildirim, Sabyasachi Baboo, Syed M Hamid, Asli E Dogan, Ozlem Tufanli, Sabrina Robichaud, Christina Emerton, Jolene K Diedrich, Hasan Vatandaslar, Fotis Nikolos, Yanghong Gu, Takao Iwawaki, Elizabeth Tarling, Mireille Ouimet, David L Nelson, John R Yates III, Peter Walter, Ebru Erbay
Format: Article
Language:English
Published: Springer Nature 2022-04-01
Series:EMBO Molecular Medicine
Subjects:
atherosclerosis
cholesterol homeostasis
efferocytosis
ER stress
translational regulation
Online Access:https://doi.org/10.15252/emmm.202115344

Internet

https://doi.org/10.15252/emmm.202115344

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