Thioredoxin-1 promotes the restoration of alveolar bone in periodontitis with diabetes
Summary: Treatment of periodontitis in people with diabetes remains challenging. The present study aimed to investigate the therapeutic potential of thioredoxin-1 (TRX1) in periodontitis with diabetes, as well as its role in modulating osteogenic differentiation. Our findings indicated that the prod...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-09-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223016954 |
| _version_ | 1797738004221001728 |
|---|---|
| author | Jinyan Wu Yaxian Huang Chi Zhan Lingling Chen Zhengmei Lin Zhi Song |
| author_facet | Jinyan Wu Yaxian Huang Chi Zhan Lingling Chen Zhengmei Lin Zhi Song |
| author_sort | Jinyan Wu |
| collection | DOAJ |
| description | Summary: Treatment of periodontitis in people with diabetes remains challenging. The present study aimed to investigate the therapeutic potential of thioredoxin-1 (TRX1) in periodontitis with diabetes, as well as its role in modulating osteogenic differentiation. Our findings indicated that the production of reactive oxygen species (ROS) was elevated, while the expression of TRX1 was significantly reduced in the periodontal tissues of periodontitis mice with diabetes. Furthermore, knockdown of TRX1 in periodontal ligament stem cells (PDLSCs) resulted in the inhibition of osteogenic differentiation through disrupting Wnt/β-catenin signaling. However, this inhibition was restored upon administration of recombinant human TRX1 (rhTRX1). Importantly, rhTRX1 treatment decreased ROS generation, activated Wnt/β-catenin signal pathway and considerably promoted the alveolar bone repair of periodontitis mice with diabetes. These findings highlighted the crucial protective role of TRX1 in periodontitis with diabetes and suggested that it may serve as a potential therapeutic target for refractory periodontitis associated with oxidative stress. |
| first_indexed | 2024-03-12T13:36:38Z |
| format | Article |
| id | doaj.art-b76e15cb57c749d3b3b7e7233b6ca848 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-12T13:36:38Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-b76e15cb57c749d3b3b7e7233b6ca8482023-08-24T04:35:26ZengElsevieriScience2589-00422023-09-01269107618Thioredoxin-1 promotes the restoration of alveolar bone in periodontitis with diabetesJinyan Wu0Yaxian Huang1Chi Zhan2Lingling Chen3Zhengmei Lin4Zhi Song5Hospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China; Yunnan Key Laboratory of Stomatology, Kunming Medical University School and Hospital of Stomatology, Kunming 650106, ChinaHospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, ChinaHospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, ChinaHospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, ChinaHospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China; Corresponding authorHospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China; Corresponding authorSummary: Treatment of periodontitis in people with diabetes remains challenging. The present study aimed to investigate the therapeutic potential of thioredoxin-1 (TRX1) in periodontitis with diabetes, as well as its role in modulating osteogenic differentiation. Our findings indicated that the production of reactive oxygen species (ROS) was elevated, while the expression of TRX1 was significantly reduced in the periodontal tissues of periodontitis mice with diabetes. Furthermore, knockdown of TRX1 in periodontal ligament stem cells (PDLSCs) resulted in the inhibition of osteogenic differentiation through disrupting Wnt/β-catenin signaling. However, this inhibition was restored upon administration of recombinant human TRX1 (rhTRX1). Importantly, rhTRX1 treatment decreased ROS generation, activated Wnt/β-catenin signal pathway and considerably promoted the alveolar bone repair of periodontitis mice with diabetes. These findings highlighted the crucial protective role of TRX1 in periodontitis with diabetes and suggested that it may serve as a potential therapeutic target for refractory periodontitis associated with oxidative stress.http://www.sciencedirect.com/science/article/pii/S2589004223016954OrthopedicsMolecular biologyCell biology |
| spellingShingle | Jinyan Wu Yaxian Huang Chi Zhan Lingling Chen Zhengmei Lin Zhi Song Thioredoxin-1 promotes the restoration of alveolar bone in periodontitis with diabetes iScience Orthopedics Molecular biology Cell biology |
| title | Thioredoxin-1 promotes the restoration of alveolar bone in periodontitis with diabetes |
| title_full | Thioredoxin-1 promotes the restoration of alveolar bone in periodontitis with diabetes |
| title_fullStr | Thioredoxin-1 promotes the restoration of alveolar bone in periodontitis with diabetes |
| title_full_unstemmed | Thioredoxin-1 promotes the restoration of alveolar bone in periodontitis with diabetes |
| title_short | Thioredoxin-1 promotes the restoration of alveolar bone in periodontitis with diabetes |
| title_sort | thioredoxin 1 promotes the restoration of alveolar bone in periodontitis with diabetes |
| topic | Orthopedics Molecular biology Cell biology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223016954 |
| work_keys_str_mv | AT jinyanwu thioredoxin1promotestherestorationofalveolarboneinperiodontitiswithdiabetes AT yaxianhuang thioredoxin1promotestherestorationofalveolarboneinperiodontitiswithdiabetes AT chizhan thioredoxin1promotestherestorationofalveolarboneinperiodontitiswithdiabetes AT linglingchen thioredoxin1promotestherestorationofalveolarboneinperiodontitiswithdiabetes AT zhengmeilin thioredoxin1promotestherestorationofalveolarboneinperiodontitiswithdiabetes AT zhisong thioredoxin1promotestherestorationofalveolarboneinperiodontitiswithdiabetes |