<i>CDKN2A</i>-Mutated Pancreatic Ductal Organoids from Induced Pluripotent Stem Cells to Model a Cancer Predisposition Syndrome

<i>CDKN2A</i>-Mutated Pancreatic Ductal Organoids from Induced Pluripotent Stem Cells to Model a Cancer Predisposition Syndrome

Patient-derived induced pluripotent stem cells (iPSCs) provide a unique platform to study hereditary disorders and predisposition syndromes by resembling germline mutations of affected individuals and by their potential to differentiate into nearly every cell type of the human body. We employed pluc...

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Bibliographic Details
Main Authors: Jessica Merkle, Markus Breunig, Maximilian Schmid, Chantal Allgöwer, Jana Krüger, Michael K. Melzer, Susanne Bens, Reiner Siebert, Lukas Perkhofer, Ninel Azoitei, Thomas Seufferlein, Sandra Heller, Matthias Meier, Martin Müller, Alexander Kleger, Meike Hohwieler
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
familial pancreatic cancer
induced pluripotent stem cells
pancreatic organoids
CDKN2A
Online Access:https://www.mdpi.com/2072-6694/13/20/5139

Internet

https://www.mdpi.com/2072-6694/13/20/5139

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