The Potential Role of C-Reactive Protein in Metabolic-Dysfunction-Associated Fatty Liver Disease and Aging
Nonalcoholic fatty liver disease (NAFLD), recently redefined as metabolic-dysfunction-associated fatty liver disease (MASLD), is liver-metabolism-associated steatohepatitis caused by nonalcoholic factors. NAFLD/MASLD is currently the most prevalent liver disease in the world, affecting one-fourth of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/10/2711 |
| _version_ | 1797574611959808000 |
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| author | Zheng Ding Yuqiu Wei Jing Peng Siyu Wang Guixi Chen Jiazeng Sun |
| author_facet | Zheng Ding Yuqiu Wei Jing Peng Siyu Wang Guixi Chen Jiazeng Sun |
| author_sort | Zheng Ding |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD), recently redefined as metabolic-dysfunction-associated fatty liver disease (MASLD), is liver-metabolism-associated steatohepatitis caused by nonalcoholic factors. NAFLD/MASLD is currently the most prevalent liver disease in the world, affecting one-fourth of the global population, and its prevalence increases with age. Current treatments are limited; one important reason hindering drug development is the insufficient understanding of the onset and pathogenesis of NAFLD/MASLD. C-reactive protein (CRP), a marker of inflammation, has been linked to NAFLD and aging in recent studies. As a conserved acute-phase protein, CRP is widely characterized for its host defense functions, but the link between CRP and NAFLD/MASLD remains unclear. Herein, we discuss the currently available evidence for the involvement of CRP in MASLD to identify areas where further research is needed. We hope this review can provide new insights into the development of aging-associated NAFLD biomarkers and suggest that modulation of CRP signaling is a potential therapeutic target. |
| first_indexed | 2024-03-10T21:25:47Z |
| format | Article |
| id | doaj.art-b76fe6ae5435450b80a8c3491f4fd663 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T21:25:47Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-b76fe6ae5435450b80a8c3491f4fd6632023-11-19T15:46:00ZengMDPI AGBiomedicines2227-90592023-10-011110271110.3390/biomedicines11102711The Potential Role of C-Reactive Protein in Metabolic-Dysfunction-Associated Fatty Liver Disease and AgingZheng Ding0Yuqiu Wei1Jing Peng2Siyu Wang3Guixi Chen4Jiazeng Sun5Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100190, ChinaKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100190, ChinaCollege of Biological Sciences, China Agricultural University, Beijing 100193, ChinaKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100190, ChinaKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100190, ChinaKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100190, ChinaNonalcoholic fatty liver disease (NAFLD), recently redefined as metabolic-dysfunction-associated fatty liver disease (MASLD), is liver-metabolism-associated steatohepatitis caused by nonalcoholic factors. NAFLD/MASLD is currently the most prevalent liver disease in the world, affecting one-fourth of the global population, and its prevalence increases with age. Current treatments are limited; one important reason hindering drug development is the insufficient understanding of the onset and pathogenesis of NAFLD/MASLD. C-reactive protein (CRP), a marker of inflammation, has been linked to NAFLD and aging in recent studies. As a conserved acute-phase protein, CRP is widely characterized for its host defense functions, but the link between CRP and NAFLD/MASLD remains unclear. Herein, we discuss the currently available evidence for the involvement of CRP in MASLD to identify areas where further research is needed. We hope this review can provide new insights into the development of aging-associated NAFLD biomarkers and suggest that modulation of CRP signaling is a potential therapeutic target.https://www.mdpi.com/2227-9059/11/10/2711C-reactive proteinmetabolic-dysfunction-associated fatty liver diseasenonalcoholic fatty liver diseaseaging |
| spellingShingle | Zheng Ding Yuqiu Wei Jing Peng Siyu Wang Guixi Chen Jiazeng Sun The Potential Role of C-Reactive Protein in Metabolic-Dysfunction-Associated Fatty Liver Disease and Aging Biomedicines C-reactive protein metabolic-dysfunction-associated fatty liver disease nonalcoholic fatty liver disease aging |
| title | The Potential Role of C-Reactive Protein in Metabolic-Dysfunction-Associated Fatty Liver Disease and Aging |
| title_full | The Potential Role of C-Reactive Protein in Metabolic-Dysfunction-Associated Fatty Liver Disease and Aging |
| title_fullStr | The Potential Role of C-Reactive Protein in Metabolic-Dysfunction-Associated Fatty Liver Disease and Aging |
| title_full_unstemmed | The Potential Role of C-Reactive Protein in Metabolic-Dysfunction-Associated Fatty Liver Disease and Aging |
| title_short | The Potential Role of C-Reactive Protein in Metabolic-Dysfunction-Associated Fatty Liver Disease and Aging |
| title_sort | potential role of c reactive protein in metabolic dysfunction associated fatty liver disease and aging |
| topic | C-reactive protein metabolic-dysfunction-associated fatty liver disease nonalcoholic fatty liver disease aging |
| url | https://www.mdpi.com/2227-9059/11/10/2711 |
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