Prognostic value of calcific aortic stenosis in patients of the PROGNOZ IBS registry
Aim. To assess the impact of calcific aortic stenosis on long-term prognosis in patients with stable coronary artery disease (CAD) included in the PROGNOZ IBS registry.Material and methods. The analysis included data of patients (n=541; men, 432; women, 109) from the CHD PROGNOSIS registry, in whom...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2022-02-01
|
| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/4836 |
| _version_ | 1797856634695843840 |
|---|---|
| author | S. N. Tolpygina A. V. Zagrebelny S. Yu. Martsevich |
| author_facet | S. N. Tolpygina A. V. Zagrebelny S. Yu. Martsevich |
| author_sort | S. N. Tolpygina |
| collection | DOAJ |
| description | Aim. To assess the impact of calcific aortic stenosis on long-term prognosis in patients with stable coronary artery disease (CAD) included in the PROGNOZ IBS registry.Material and methods. The analysis included data of patients (n=541; men, 432; women, 109) from the CHD PROGNOSIS registry, in whom diagnosis of CAD was confirmed using coronary angiography during reference hospitalization in the National Medical Research Center for the period from January 1, to December 31, 2007. The mean age of men was 57,5±0,4, women — 60,9±0,9 years. The survival analysis included 504 patients (93%). The mean follow-up period was 7,3±2,19 years. We assessed the presence of calcific aortic stenosis (CAS) according to echocardiography and data on endpoints after 4 and 7 years of follow-up.Results. CAS according to echocardiography during reference hospitalization was found in 29 patients (5,4%) with a confirmed CAD. After four-year followup, 7 patients (24,1%) died, after 7 years — 15 (51,7%). Fatal and non-fatal cardiovascular events (primary endpoint) after 4 years were revealed in 10 patients (34,5%), and after 7 years, all cardiovascular events were fatal (n=15; 51,7%). In the presence of aortic stenosis, the relative risk (RR) of all-cause death at 4-year follow-up increased by 2,9 times (p<0,01), while at 7-year follow-up — by 3,2 (p<0,0001). The RR for the primary endpoint at 4-year follow-up increased by 2,8 times (p<0,01), while at 7-year follow-up — by 2,3 times (p<0,001). The RR of death in CAS patients at 7-year follow-up was comparable to severe heart failure — 3,3 (p<0,01), stroke — 2,4 (p<0,05) and left main coronary artery stenosis — 2,5 (p<0,0001).Conclusion. The presence of calcific aortic stenosis had a pronounced negative effect on the long-term prognosis of CAD patients, comparable with those in left main coronary artery stenosis, severe heart failure and stroke. |
| first_indexed | 2024-04-09T20:43:37Z |
| format | Article |
| id | doaj.art-b76ff5b0a9fa4cdd941204c1a2aa8c21 |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2024-04-09T20:43:37Z |
| publishDate | 2022-02-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-b76ff5b0a9fa4cdd941204c1a2aa8c212023-03-29T21:23:40Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202022-02-0127110.15829/1560-4071-2022-48363482Prognostic value of calcific aortic stenosis in patients of the PROGNOZ IBS registryS. N. Tolpygina0A. V. Zagrebelny1S. Yu. Martsevich2National Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineAim. To assess the impact of calcific aortic stenosis on long-term prognosis in patients with stable coronary artery disease (CAD) included in the PROGNOZ IBS registry.Material and methods. The analysis included data of patients (n=541; men, 432; women, 109) from the CHD PROGNOSIS registry, in whom diagnosis of CAD was confirmed using coronary angiography during reference hospitalization in the National Medical Research Center for the period from January 1, to December 31, 2007. The mean age of men was 57,5±0,4, women — 60,9±0,9 years. The survival analysis included 504 patients (93%). The mean follow-up period was 7,3±2,19 years. We assessed the presence of calcific aortic stenosis (CAS) according to echocardiography and data on endpoints after 4 and 7 years of follow-up.Results. CAS according to echocardiography during reference hospitalization was found in 29 patients (5,4%) with a confirmed CAD. After four-year followup, 7 patients (24,1%) died, after 7 years — 15 (51,7%). Fatal and non-fatal cardiovascular events (primary endpoint) after 4 years were revealed in 10 patients (34,5%), and after 7 years, all cardiovascular events were fatal (n=15; 51,7%). In the presence of aortic stenosis, the relative risk (RR) of all-cause death at 4-year follow-up increased by 2,9 times (p<0,01), while at 7-year follow-up — by 3,2 (p<0,0001). The RR for the primary endpoint at 4-year follow-up increased by 2,8 times (p<0,01), while at 7-year follow-up — by 2,3 times (p<0,001). The RR of death in CAS patients at 7-year follow-up was comparable to severe heart failure — 3,3 (p<0,01), stroke — 2,4 (p<0,05) and left main coronary artery stenosis — 2,5 (p<0,0001).Conclusion. The presence of calcific aortic stenosis had a pronounced negative effect on the long-term prognosis of CAD patients, comparable with those in left main coronary artery stenosis, severe heart failure and stroke.https://russjcardiol.elpub.ru/jour/article/view/4836valvular heart diseasecalcific aortic stenosischronic coronary artery diseaseregistrylong-term prognosis |
| spellingShingle | S. N. Tolpygina A. V. Zagrebelny S. Yu. Martsevich Prognostic value of calcific aortic stenosis in patients of the PROGNOZ IBS registry Российский кардиологический журнал valvular heart disease calcific aortic stenosis chronic coronary artery disease registry long-term prognosis |
| title | Prognostic value of calcific aortic stenosis in patients of the PROGNOZ IBS registry |
| title_full | Prognostic value of calcific aortic stenosis in patients of the PROGNOZ IBS registry |
| title_fullStr | Prognostic value of calcific aortic stenosis in patients of the PROGNOZ IBS registry |
| title_full_unstemmed | Prognostic value of calcific aortic stenosis in patients of the PROGNOZ IBS registry |
| title_short | Prognostic value of calcific aortic stenosis in patients of the PROGNOZ IBS registry |
| title_sort | prognostic value of calcific aortic stenosis in patients of the prognoz ibs registry |
| topic | valvular heart disease calcific aortic stenosis chronic coronary artery disease registry long-term prognosis |
| url | https://russjcardiol.elpub.ru/jour/article/view/4836 |
| work_keys_str_mv | AT sntolpygina prognosticvalueofcalcificaorticstenosisinpatientsoftheprognozibsregistry AT avzagrebelny prognosticvalueofcalcificaorticstenosisinpatientsoftheprognozibsregistry AT syumartsevich prognosticvalueofcalcificaorticstenosisinpatientsoftheprognozibsregistry |