MLF2 Negatively Regulates P53 and Promotes Colorectal Carcinogenesis

MLF2 Negatively Regulates P53 and Promotes Colorectal Carcinogenesis

Abstract Inactivation of the p53 pathway is linked to a variety of human cancers. As a critical component of the p53 pathway, ubiquitin‐specific protease 7 (USP7) acts as a deubiquitinase for both p53 and its ubiquitin E3 ligase mouse double minute 2 homolog. Here, myeloid leukemia factor 2 (MLF2) i...

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Bibliographic Details
Main Authors: Debao Fang, Hao Hu, Kailiang Zhao, Aman Xu, Changjun Yu, Yong Zhu, Ning Yu, Bo Yao, Suyun Tang, Xianning Wu, Yide Mei
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Advanced Science
Subjects:
colorectal cancer
myeloid leukemia factor 2 (MLF2)
p53
ubiquitin‐specific protease 7 (USP7)
Online Access:https://doi.org/10.1002/advs.202303336

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