Investigation of Association Between KISS1R rs397515615 Polymorphism with Idiopathic Male Infertility
Background: Infertility referes to the inability of a couple to conceive over an average period of one year with unprotected sexual intercourse. In mammals, Fertility is initiated at puberty by the pulsatile secretion of gonadotrophin releasing hormone (GnRH). Kisspeptin (product of Kiss1 gene) and...
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| Format: | Article |
| Language: | English |
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Bushehr University of Medical Sciences
2017-07-01
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| Series: | Iranian South Medical Journal |
| Subjects: | |
| Online Access: | http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-774&slc_lang=en&sid=1 |
| _version_ | 1811294880351125504 |
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| author | Azadeh Poursharif Hamidreza Vaziri Toba Mirzapour |
| author_facet | Azadeh Poursharif Hamidreza Vaziri Toba Mirzapour |
| author_sort | Azadeh Poursharif |
| collection | DOAJ |
| description | Background: Infertility referes to the inability of a couple to conceive over an average period of one year with unprotected sexual intercourse. In mammals, Fertility is initiated at puberty by the pulsatile secretion of gonadotrophin releasing hormone (GnRH). Kisspeptin (product of Kiss1 gene) and its receptor (KISS1R) are as vital upstream regulatorsin integrating of central and peripheral signals with GnRH release. In this paper, we studied an association between polymorphism rs 397515615 in the KISS1R gene with idiopathic male infertility.
Material and Methods: In this research, we were evaluated a total of 50 men with idiopathic infertility and 50 healthy men (control group). AS-PCR method was applied for determination of the codon polymorphism. Also we used chi-square (χ2) test to study of an association between genotype and allele frequencies in cases and control groups.
Results: The results showed that the genotypic frequencies between two groups revealed a significant difference between the patients and healthy (P=0.02), while Allele distribution (G/-) between case and control groups was not significant (P=0.20).
Conclusion: The results of this study show that the polymorphism of rs 397515615 KISS1R gene probably associated with idiopathic infertility in men. However, further studies with larger and different geographical population are needed to confirm the results. |
| first_indexed | 2024-04-13T05:24:57Z |
| format | Article |
| id | doaj.art-b774653e387947e8b115eb00d93b34da |
| institution | Directory Open Access Journal |
| issn | 1735-4374 1735-6954 |
| language | English |
| last_indexed | 2024-04-13T05:24:57Z |
| publishDate | 2017-07-01 |
| publisher | Bushehr University of Medical Sciences |
| record_format | Article |
| series | Iranian South Medical Journal |
| spelling | doaj.art-b774653e387947e8b115eb00d93b34da2022-12-22T03:00:38ZengBushehr University of Medical SciencesIranian South Medical Journal1735-43741735-69542017-07-01203257266Investigation of Association Between KISS1R rs397515615 Polymorphism with Idiopathic Male InfertilityAzadeh Poursharif0Hamidreza Vaziri1Toba Mirzapour2 Department of Biology, School of Science, University of Guilan, Guilan, Iran Department of Biology, School of Science, University of Guilan, Guilan, Iran Department of Biology, School of Science, University of Mohaghegh Ardabili, Ardabil, Iran Background: Infertility referes to the inability of a couple to conceive over an average period of one year with unprotected sexual intercourse. In mammals, Fertility is initiated at puberty by the pulsatile secretion of gonadotrophin releasing hormone (GnRH). Kisspeptin (product of Kiss1 gene) and its receptor (KISS1R) are as vital upstream regulatorsin integrating of central and peripheral signals with GnRH release. In this paper, we studied an association between polymorphism rs 397515615 in the KISS1R gene with idiopathic male infertility. Material and Methods: In this research, we were evaluated a total of 50 men with idiopathic infertility and 50 healthy men (control group). AS-PCR method was applied for determination of the codon polymorphism. Also we used chi-square (χ2) test to study of an association between genotype and allele frequencies in cases and control groups. Results: The results showed that the genotypic frequencies between two groups revealed a significant difference between the patients and healthy (P=0.02), while Allele distribution (G/-) between case and control groups was not significant (P=0.20). Conclusion: The results of this study show that the polymorphism of rs 397515615 KISS1R gene probably associated with idiopathic infertility in men. However, further studies with larger and different geographical population are needed to confirm the results.http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-774&slc_lang=en&sid=1rs 397515615 KISS1R gene Male-factor Infertility Polymorphism |
| spellingShingle | Azadeh Poursharif Hamidreza Vaziri Toba Mirzapour Investigation of Association Between KISS1R rs397515615 Polymorphism with Idiopathic Male Infertility Iranian South Medical Journal rs 397515615 KISS1R gene Male-factor Infertility Polymorphism |
| title | Investigation of Association Between KISS1R rs397515615 Polymorphism with Idiopathic Male Infertility |
| title_full | Investigation of Association Between KISS1R rs397515615 Polymorphism with Idiopathic Male Infertility |
| title_fullStr | Investigation of Association Between KISS1R rs397515615 Polymorphism with Idiopathic Male Infertility |
| title_full_unstemmed | Investigation of Association Between KISS1R rs397515615 Polymorphism with Idiopathic Male Infertility |
| title_short | Investigation of Association Between KISS1R rs397515615 Polymorphism with Idiopathic Male Infertility |
| title_sort | investigation of association between kiss1r rs397515615 polymorphism with idiopathic male infertility |
| topic | rs 397515615 KISS1R gene Male-factor Infertility Polymorphism |
| url | http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-774&slc_lang=en&sid=1 |
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