KLHL3-dependent WNK4 degradation affected by potassium through the neddylation and autophagy pathway

KLHL3-dependent WNK4 degradation affected by potassium through the neddylation and autophagy pathway

Abstract Background Studies reported that kelch-like protein 3 (KLHL3)-Cullin3(CUL3) E3 ligase ubiquitinated with-no-lysine kinase 4 (WNK4). Impaired WNK4 ubiquitination plays a key role in Familial hyperkalemic hypertension (FHHt, also called pseudohypoaldosteronism type II) which results from over...

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Bibliographic Details
Main Authors: Siqi Ying, Qin Guo, Chong Zhang
Format: Article
Language:English
Published: BMC 2023-07-01
Series:BMC Nephrology
Subjects:
KLHL3
CUL3
WNK4
Potassium
Neddylation
Autophagy
Online Access:https://doi.org/10.1186/s12882-023-03257-4

Internet

https://doi.org/10.1186/s12882-023-03257-4

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