Is Microsporidial keratitis an emerging cause of stromal keratitis? – a case series study
<p>Abstract</p> <p>Background</p> <p>Microsporidial keratitis is a rare cause of stromal keratitis. We present a series of five cases of microsporidial keratitis from a single centre in southern India with microbiologic and histopathologic features.</p> <p>C...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2005-08-01
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| Series: | BMC Ophthalmology |
| Online Access: | http://www.biomedcentral.com/1471-2415/5/19 |
| _version_ | 1818143196578840576 |
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| author | Gopinathan Usha Joseph Joveeta Sharma Savitri Garg Prashant Vemuganti Geeta K Singh Shashi |
| author_facet | Gopinathan Usha Joseph Joveeta Sharma Savitri Garg Prashant Vemuganti Geeta K Singh Shashi |
| author_sort | Gopinathan Usha |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Microsporidial keratitis is a rare cause of stromal keratitis. We present a series of five cases of microsporidial keratitis from a single centre in southern India with microbiologic and histopathologic features.</p> <p>Case presentation</p> <p>Patient charts of five cases of microsporidial stromal keratitis diagnosed between January 2002 and June 2004 were reviewed retrospectively for clinical data, microbiologic and histopathologic data. The presence of microsporidia was confirmed by special stains on corneal scrapings and/or corneal tissues, and electron microscopy. All patients were immunocompetent with a preceding history of trauma in three. Four patients presented with unilateral, small, persisting deep stromal infiltrates, of uncertain etiology, in the cornea, which were not responding to conventional antimicrobial treatment and required penetrating keratoplasty in three. Fifth case was unsuspected and underwent keratoplasty for post-traumatic scar. Three of five cases were diagnosed on corneal scrapings, prior to keratoplasty, while two were diagnosed only on histology. The microsporidia appeared as oval well defined bodies with dense staining at one pole. None of the patients showed recurrence following keratoplasty.</p> <p>Conclusion</p> <p>Microsporidia, though rare, should be suspected in chronic culture-negative stromal keratitis. Organisms could lie dormant without associated inflammation.</p> |
| first_indexed | 2024-12-11T11:27:50Z |
| format | Article |
| id | doaj.art-b7782bb54cb24e76ae87907c2594f26a |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-11T11:27:50Z |
| publishDate | 2005-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-b7782bb54cb24e76ae87907c2594f26a2022-12-22T01:08:58ZengBMCBMC Ophthalmology1471-24152005-08-01511910.1186/1471-2415-5-19Is Microsporidial keratitis an emerging cause of stromal keratitis? – a case series studyGopinathan UshaJoseph JoveetaSharma SavitriGarg PrashantVemuganti Geeta KSingh Shashi<p>Abstract</p> <p>Background</p> <p>Microsporidial keratitis is a rare cause of stromal keratitis. We present a series of five cases of microsporidial keratitis from a single centre in southern India with microbiologic and histopathologic features.</p> <p>Case presentation</p> <p>Patient charts of five cases of microsporidial stromal keratitis diagnosed between January 2002 and June 2004 were reviewed retrospectively for clinical data, microbiologic and histopathologic data. The presence of microsporidia was confirmed by special stains on corneal scrapings and/or corneal tissues, and electron microscopy. All patients were immunocompetent with a preceding history of trauma in three. Four patients presented with unilateral, small, persisting deep stromal infiltrates, of uncertain etiology, in the cornea, which were not responding to conventional antimicrobial treatment and required penetrating keratoplasty in three. Fifth case was unsuspected and underwent keratoplasty for post-traumatic scar. Three of five cases were diagnosed on corneal scrapings, prior to keratoplasty, while two were diagnosed only on histology. The microsporidia appeared as oval well defined bodies with dense staining at one pole. None of the patients showed recurrence following keratoplasty.</p> <p>Conclusion</p> <p>Microsporidia, though rare, should be suspected in chronic culture-negative stromal keratitis. Organisms could lie dormant without associated inflammation.</p>http://www.biomedcentral.com/1471-2415/5/19 |
| spellingShingle | Gopinathan Usha Joseph Joveeta Sharma Savitri Garg Prashant Vemuganti Geeta K Singh Shashi Is Microsporidial keratitis an emerging cause of stromal keratitis? – a case series study BMC Ophthalmology |
| title | Is Microsporidial keratitis an emerging cause of stromal keratitis? – a case series study |
| title_full | Is Microsporidial keratitis an emerging cause of stromal keratitis? – a case series study |
| title_fullStr | Is Microsporidial keratitis an emerging cause of stromal keratitis? – a case series study |
| title_full_unstemmed | Is Microsporidial keratitis an emerging cause of stromal keratitis? – a case series study |
| title_short | Is Microsporidial keratitis an emerging cause of stromal keratitis? – a case series study |
| title_sort | is microsporidial keratitis an emerging cause of stromal keratitis a case series study |
| url | http://www.biomedcentral.com/1471-2415/5/19 |
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