A Solitary Melanoma Metastasis Confined to the Submandibular Gland
Malignant melanoma is a type of cancer that most commonly originates from the skin, less frequently from mucosal surfaces, the eye, or meninges [Annu Rev Pathol. 2014;9(1):239–71]. In 2019, this type of malignancy was the third most frequent cancer to be diagnosed in males and the fifth most in fema...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2021-06-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/516796 |
| _version_ | 1819299339067981824 |
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| author | Senne Gorris Celia Perdaens Veerle Delvaux Vincent Vander Poorten Bart Neyns Ilan Baron |
| author_facet | Senne Gorris Celia Perdaens Veerle Delvaux Vincent Vander Poorten Bart Neyns Ilan Baron |
| author_sort | Senne Gorris |
| collection | DOAJ |
| description | Malignant melanoma is a type of cancer that most commonly originates from the skin, less frequently from mucosal surfaces, the eye, or meninges [Annu Rev Pathol. 2014;9(1):239–71]. In 2019, this type of malignancy was the third most frequent cancer to be diagnosed in males and the fifth most in females according to the American Cancer Society and the National Cancer Institute [CA Cancer J Clin. 2019;69(5):363–85]. The majority of the malignant melanomas in the head and neck region (85–90%) are cutaneous lesions, most often arising in the skin of the face [Head Neck. 2016;38:147–155]. In sharp contrast are the histological findings of metastatic melanoma with an unknown primary site: they are much more scarce and histologically difficult to diagnose. The literature is limited to case studies or small cohorts. In 2–6% of all patients suffering from metastatic melanoma, after clinical examination of the skin and mucosa, imaging, and other diagnostic examination, a primary tumor cannot be found [Eur J Cancer. 2004;40(9):1454–5]. A very small subgroup (0.5%) presents with a single focus of melanoma within the dermis or subcutaneous tissues [Arch Dermatol. 2000;136(11):1397–9]. We hereby report a case in this subgroup of a solitary melanoma metastasis found in the submandibular gland in a 59-year-old male. The tumor was discovered incidentally after surgical excision of this gland because of nodular enlargement. |
| first_indexed | 2024-12-24T05:44:13Z |
| format | Article |
| id | doaj.art-b77906ea716c464aa057ab636e5f508d |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-24T05:44:13Z |
| publishDate | 2021-06-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-b77906ea716c464aa057ab636e5f508d2022-12-21T17:12:40ZengKarger PublishersCase Reports in Oncology1662-65752021-06-0114295796210.1159/000516796516796A Solitary Melanoma Metastasis Confined to the Submandibular GlandSenne Gorris0https://orcid.org/0000-0002-2613-669XCelia Perdaens1Veerle Delvaux2Vincent Vander Poorten3Bart Neyns4Ilan Baron5Department of Otorhinolaryngology Head and Neck Surgery, University Hospitals Leuven, KU Leuven, Leuven, BelgiumDepartment of Anatomic pathology, AZ Jan Portaels, Vilvoorde, BelgiumDepartment of Anatomic pathology, AZ Jan Portaels, Vilvoorde, BelgiumDepartment of Otorhinolaryngology Head and Neck Surgery, University Hospitals Leuven, KU Leuven, Leuven, BelgiumDepartment of Medical Oncology, University Hospital Brussel, Brussels, BelgiumDepartment of Otorhinolaryngology Head and Neck Surgery, AZ Jan Portaels, Vilvoorde, BelgiumMalignant melanoma is a type of cancer that most commonly originates from the skin, less frequently from mucosal surfaces, the eye, or meninges [Annu Rev Pathol. 2014;9(1):239–71]. In 2019, this type of malignancy was the third most frequent cancer to be diagnosed in males and the fifth most in females according to the American Cancer Society and the National Cancer Institute [CA Cancer J Clin. 2019;69(5):363–85]. The majority of the malignant melanomas in the head and neck region (85–90%) are cutaneous lesions, most often arising in the skin of the face [Head Neck. 2016;38:147–155]. In sharp contrast are the histological findings of metastatic melanoma with an unknown primary site: they are much more scarce and histologically difficult to diagnose. The literature is limited to case studies or small cohorts. In 2–6% of all patients suffering from metastatic melanoma, after clinical examination of the skin and mucosa, imaging, and other diagnostic examination, a primary tumor cannot be found [Eur J Cancer. 2004;40(9):1454–5]. A very small subgroup (0.5%) presents with a single focus of melanoma within the dermis or subcutaneous tissues [Arch Dermatol. 2000;136(11):1397–9]. We hereby report a case in this subgroup of a solitary melanoma metastasis found in the submandibular gland in a 59-year-old male. The tumor was discovered incidentally after surgical excision of this gland because of nodular enlargement.https://www.karger.com/Article/FullText/516796metastatic melanomasubmandibular glandimmunotherapyunknown primarycase report |
| spellingShingle | Senne Gorris Celia Perdaens Veerle Delvaux Vincent Vander Poorten Bart Neyns Ilan Baron A Solitary Melanoma Metastasis Confined to the Submandibular Gland Case Reports in Oncology metastatic melanoma submandibular gland immunotherapy unknown primary case report |
| title | A Solitary Melanoma Metastasis Confined to the Submandibular Gland |
| title_full | A Solitary Melanoma Metastasis Confined to the Submandibular Gland |
| title_fullStr | A Solitary Melanoma Metastasis Confined to the Submandibular Gland |
| title_full_unstemmed | A Solitary Melanoma Metastasis Confined to the Submandibular Gland |
| title_short | A Solitary Melanoma Metastasis Confined to the Submandibular Gland |
| title_sort | solitary melanoma metastasis confined to the submandibular gland |
| topic | metastatic melanoma submandibular gland immunotherapy unknown primary case report |
| url | https://www.karger.com/Article/FullText/516796 |
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