Cryopreserved anti-CD22 and bispecific anti-CD19/22 CAR T cells are as effective as freshly infused cells

Cryopreserved anti-CD22 and bispecific anti-CD19/22 CAR T cells are as effective as freshly infused cells

Cryopreservation of chimeric antigen receptor (CAR) T cells facilitates shipment, timing of infusions, and storage of subsequent doses. However, reports on the impact of cryopreservation on CAR T cell efficacy have been mixed. We retrospectively compared clinical outcomes between patients who receiv...

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Bibliographic Details
Main Authors: Alexandra Dreyzin, Sandhya R. Panch, Haneen Shalabi, Bonnie Yates, Steven L. Highfill, Ping Jin, David Stroncek, Nirali N. Shah
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
cell therapy
CAR T
clinical outcomes
cryopreservation
CAR T manufacturing
cytokine release syndrome
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050122001772

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