The Era of the FLips: How Spike Mutations L455F and F456L (and A475V) Are Shaping SARS-CoV-2 Evolution
Convergent evolution of the SARS-CoV-2 Spike protein has been mostly driven by immune escape, in particular by escape to the viral infection-neutralizing antibodies (nAbs) elicited by previous infections and/or vaccinations [...]
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-12-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/16/1/3 |
| _version_ | 1797342470380453888 |
|---|---|
| author | Daniele Focosi Pietro Giorgio Spezia Federico Gueli Fabrizio Maggi |
| author_facet | Daniele Focosi Pietro Giorgio Spezia Federico Gueli Fabrizio Maggi |
| author_sort | Daniele Focosi |
| collection | DOAJ |
| description | Convergent evolution of the SARS-CoV-2 Spike protein has been mostly driven by immune escape, in particular by escape to the viral infection-neutralizing antibodies (nAbs) elicited by previous infections and/or vaccinations [...] |
| first_indexed | 2024-03-08T10:33:44Z |
| format | Article |
| id | doaj.art-b77b385b430a4e589c6ec332b0795ec7 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-08T10:33:44Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-b77b385b430a4e589c6ec332b0795ec72024-01-26T18:46:10ZengMDPI AGViruses1999-49152023-12-01161310.3390/v16010003The Era of the FLips: How Spike Mutations L455F and F456L (and A475V) Are Shaping SARS-CoV-2 EvolutionDaniele Focosi0Pietro Giorgio Spezia1Federico Gueli2Fabrizio Maggi3North-Western Tuscany Blood Bank, Pisa University Hospital, 56124 Pisa, ItalyNational Institute for Infectious Diseases “Lazzaro Spallanzani” IRCCS, 00149 Rome, ItalyIndependent Researcher, 22100 Como, ItalyNational Institute for Infectious Diseases “Lazzaro Spallanzani” IRCCS, 00149 Rome, ItalyConvergent evolution of the SARS-CoV-2 Spike protein has been mostly driven by immune escape, in particular by escape to the viral infection-neutralizing antibodies (nAbs) elicited by previous infections and/or vaccinations [...]https://www.mdpi.com/1999-4915/16/1/3n/a |
| spellingShingle | Daniele Focosi Pietro Giorgio Spezia Federico Gueli Fabrizio Maggi The Era of the FLips: How Spike Mutations L455F and F456L (and A475V) Are Shaping SARS-CoV-2 Evolution Viruses n/a |
| title | The Era of the FLips: How Spike Mutations L455F and F456L (and A475V) Are Shaping SARS-CoV-2 Evolution |
| title_full | The Era of the FLips: How Spike Mutations L455F and F456L (and A475V) Are Shaping SARS-CoV-2 Evolution |
| title_fullStr | The Era of the FLips: How Spike Mutations L455F and F456L (and A475V) Are Shaping SARS-CoV-2 Evolution |
| title_full_unstemmed | The Era of the FLips: How Spike Mutations L455F and F456L (and A475V) Are Shaping SARS-CoV-2 Evolution |
| title_short | The Era of the FLips: How Spike Mutations L455F and F456L (and A475V) Are Shaping SARS-CoV-2 Evolution |
| title_sort | era of the flips how spike mutations l455f and f456l and a475v are shaping sars cov 2 evolution |
| topic | n/a |
| url | https://www.mdpi.com/1999-4915/16/1/3 |
| work_keys_str_mv | AT danielefocosi theeraoftheflipshowspikemutationsl455fandf456landa475vareshapingsarscov2evolution AT pietrogiorgiospezia theeraoftheflipshowspikemutationsl455fandf456landa475vareshapingsarscov2evolution AT federicogueli theeraoftheflipshowspikemutationsl455fandf456landa475vareshapingsarscov2evolution AT fabriziomaggi theeraoftheflipshowspikemutationsl455fandf456landa475vareshapingsarscov2evolution AT danielefocosi eraoftheflipshowspikemutationsl455fandf456landa475vareshapingsarscov2evolution AT pietrogiorgiospezia eraoftheflipshowspikemutationsl455fandf456landa475vareshapingsarscov2evolution AT federicogueli eraoftheflipshowspikemutationsl455fandf456landa475vareshapingsarscov2evolution AT fabriziomaggi eraoftheflipshowspikemutationsl455fandf456landa475vareshapingsarscov2evolution |