Efficacy and Safety of Enteral Human Recombinant Insulin to Reduce the Time to Full Enteral Feeding in Preterm Infants: A Meta-Analytical Study
Recombinant human insulin plays an important role in the gut maturation of preterm infants. This meta-analysis was carried out to assess the efficacy and safety of enteral recombinant human insulin in decreasing the time to full enteral feeding in preterm infants. The pooling of data from four clini...
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| Format: | Article |
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MDPI AG
2023-06-01
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| Series: | Pediatric Reports |
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| Online Access: | https://www.mdpi.com/2036-7503/15/2/33 |
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| author | Faiza Qudsia Muhammad Adil Maha Kamran Muhammad Azam Huzaifa Ahmad Cheema Abia Shahid Ivan Cherrez-Ojeda |
| author_facet | Faiza Qudsia Muhammad Adil Maha Kamran Muhammad Azam Huzaifa Ahmad Cheema Abia Shahid Ivan Cherrez-Ojeda |
| author_sort | Faiza Qudsia |
| collection | DOAJ |
| description | Recombinant human insulin plays an important role in the gut maturation of preterm infants. This meta-analysis was carried out to assess the efficacy and safety of enteral recombinant human insulin in decreasing the time to full enteral feeding in preterm infants. The pooling of data from four clinical trials yielded a significant decrease in the time to full enteral feeding in preterm infants under both low (Mean difference [MD] −3.43 days; 95% CI: −6.18 to −0.69 days; I2 = 48%) and high doses of insulin (MD −7.10 days; 95% CI: −10.02 to −4.18 days; I2 = 0%). These findings require confirmation by further large trials that evaluate the efficacy and safety of enteral insulin, especially at supraphysiological doses. |
| first_indexed | 2024-03-11T02:03:33Z |
| format | Article |
| id | doaj.art-b77bd3c893664bdf980add0eb6c686e0 |
| institution | Directory Open Access Journal |
| issn | 2036-7503 |
| language | English |
| last_indexed | 2024-03-11T02:03:33Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pediatric Reports |
| spelling | doaj.art-b77bd3c893664bdf980add0eb6c686e02023-11-18T12:01:17ZengMDPI AGPediatric Reports2036-75032023-06-0115237338010.3390/pediatric15020033Efficacy and Safety of Enteral Human Recombinant Insulin to Reduce the Time to Full Enteral Feeding in Preterm Infants: A Meta-Analytical StudyFaiza Qudsia0Muhammad Adil1Maha Kamran2Muhammad Azam3Huzaifa Ahmad Cheema4Abia Shahid5Ivan Cherrez-Ojeda6Department of Medicine, King Edward Medical University, Lahore 54000, PakistanDepartment of Medicine, King Edward Medical University, Lahore 54000, PakistanDepartment of Medicine, King Edward Medical University, Lahore 54000, PakistanDepartment of Medicine, Allama Iqbal Medical College, Lahore 54550, PakistanDepartment of Medicine, King Edward Medical University, Lahore 54000, PakistanDepartment of Paediatrics, King Edward Medical University, Lahore 54000, PakistanRespiralab Research Center, Guayaquil 090512, EcuadorRecombinant human insulin plays an important role in the gut maturation of preterm infants. This meta-analysis was carried out to assess the efficacy and safety of enteral recombinant human insulin in decreasing the time to full enteral feeding in preterm infants. The pooling of data from four clinical trials yielded a significant decrease in the time to full enteral feeding in preterm infants under both low (Mean difference [MD] −3.43 days; 95% CI: −6.18 to −0.69 days; I2 = 48%) and high doses of insulin (MD −7.10 days; 95% CI: −10.02 to −4.18 days; I2 = 0%). These findings require confirmation by further large trials that evaluate the efficacy and safety of enteral insulin, especially at supraphysiological doses.https://www.mdpi.com/2036-7503/15/2/33enteral insulinpreterm infantsenteral feedingmeta-analysis |
| spellingShingle | Faiza Qudsia Muhammad Adil Maha Kamran Muhammad Azam Huzaifa Ahmad Cheema Abia Shahid Ivan Cherrez-Ojeda Efficacy and Safety of Enteral Human Recombinant Insulin to Reduce the Time to Full Enteral Feeding in Preterm Infants: A Meta-Analytical Study Pediatric Reports enteral insulin preterm infants enteral feeding meta-analysis |
| title | Efficacy and Safety of Enteral Human Recombinant Insulin to Reduce the Time to Full Enteral Feeding in Preterm Infants: A Meta-Analytical Study |
| title_full | Efficacy and Safety of Enteral Human Recombinant Insulin to Reduce the Time to Full Enteral Feeding in Preterm Infants: A Meta-Analytical Study |
| title_fullStr | Efficacy and Safety of Enteral Human Recombinant Insulin to Reduce the Time to Full Enteral Feeding in Preterm Infants: A Meta-Analytical Study |
| title_full_unstemmed | Efficacy and Safety of Enteral Human Recombinant Insulin to Reduce the Time to Full Enteral Feeding in Preterm Infants: A Meta-Analytical Study |
| title_short | Efficacy and Safety of Enteral Human Recombinant Insulin to Reduce the Time to Full Enteral Feeding in Preterm Infants: A Meta-Analytical Study |
| title_sort | efficacy and safety of enteral human recombinant insulin to reduce the time to full enteral feeding in preterm infants a meta analytical study |
| topic | enteral insulin preterm infants enteral feeding meta-analysis |
| url | https://www.mdpi.com/2036-7503/15/2/33 |
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