Evaluation the interaction of ABC multidrug transporter MDR1 with thymoquinone: substrate or inhibitor?

Evaluation the interaction of ABC multidrug transporter MDR1 with thymoquinone: substrate or inhibitor?

<em><strong>Objective(s):</strong></em> Thymoquinone (TQ) has valuable medical properties like anticancer effects. Development of multidrug resistance (MDR) phenotype is one of the most important factors in failure of cancer chemotherapy. The aim of this study was to evaluate...

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Main Authors: vahideh keyvani, Zeynab Naserifar, Mohammad-Reza Saberi, seyed ahmad mohajeri, Sepideh Arabzadeh, Farajollah Shahriari Ahmadi, Hossein Hosseinzadeh, Seyedeh Mahya Shariat Razavi, Fatemeh Kalalinia
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2020-10-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
drug transporters
mdr1
multi drug resistance
nigella sativa
thymoquinone
Online Access:http://ijbms.mums.ac.ir/article_16401_fa7ac0093644230776f5f1c38aa249fc.pdf

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