Anti-Cancer Acitivity of Etodolac and Its Derivatives on Prostate and Colorectal Cancer Cell Lines
Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used as anti-inflammatory and analgesic agents. This family of drugs suppresses prostaglandin synthesis through inhibition of cyclooxygenase (COX) enzymes. Recent studies showed that anti-carcinogenic effects of these drugs are especially me...
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| Format: | Article |
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MDPI AG
2018-12-01
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| Series: | Proceedings |
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| Online Access: | https://www.mdpi.com/2504-3900/2/25/1573 |
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| author | Sevgi Koçyiğit Sevinç Oya Orun Pınar Mega Tiber Pelin Çıkla-Süzgün Ş. Güniz Küçükgüzel |
| author_facet | Sevgi Koçyiğit Sevinç Oya Orun Pınar Mega Tiber Pelin Çıkla-Süzgün Ş. Güniz Küçükgüzel |
| author_sort | Sevgi Koçyiğit Sevinç |
| collection | DOAJ |
| description | Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used as anti-inflammatory and analgesic agents. This family of drugs suppresses prostaglandin synthesis through inhibition of cyclooxygenase (COX) enzymes. Recent studies showed that anti-carcinogenic effects of these drugs are especially mediated by COX-2 enzyme. Etodolac is a COX-2 inhibitor and though not perfectly selective, it exhibits “preferential selectivity„ for COX-2. In this study, the anti-proliferative and apoptotic effects of etodolac and its hydrazone or triazole derivatives (SGK 206 and SGK 242, respectively), were investigated on prostate cancer cell line PC-3 and human colorectal carcinoma cell line HT-29. Our data showed that SGK 206 and SGK 242 were more effective in the inhibition of proliferation and induction of apoptosis compared to etodolac in both cell lines. |
| first_indexed | 2024-04-12T17:44:31Z |
| format | Article |
| id | doaj.art-b77fa821a1d04c118c7d49a6fcb558a7 |
| institution | Directory Open Access Journal |
| issn | 2504-3900 |
| language | English |
| last_indexed | 2025-03-20T06:20:37Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Proceedings |
| spelling | doaj.art-b77fa821a1d04c118c7d49a6fcb558a72024-10-02T15:11:38ZengMDPI AGProceedings2504-39002018-12-01225157310.3390/proceedings2251573proceedings2251573Anti-Cancer Acitivity of Etodolac and Its Derivatives on Prostate and Colorectal Cancer Cell LinesSevgi Koçyiğit Sevinç0Oya Orun1Pınar Mega Tiber2Pelin Çıkla-Süzgün3Ş. Güniz Küçükgüzel4School of Medicine, Department of Biophysics, Maltepe, Marmara University, 34854 Istanbul, TurkeySchool of Medicine, Department of Biophysics, Maltepe, Marmara University, 34854 Istanbul, TurkeySchool of Medicine, Department of Biophysics, Maltepe, Marmara University, 34854 Istanbul, TurkeySchool of Pharmacy, Department of Pharmaceutical Chemistry, Marmara University, Haydarpasa, 34668 Istanbul, TurkeySchool of Pharmacy, Department of Pharmaceutical Chemistry, Marmara University, Haydarpasa, 34668 Istanbul, TurkeyNonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used as anti-inflammatory and analgesic agents. This family of drugs suppresses prostaglandin synthesis through inhibition of cyclooxygenase (COX) enzymes. Recent studies showed that anti-carcinogenic effects of these drugs are especially mediated by COX-2 enzyme. Etodolac is a COX-2 inhibitor and though not perfectly selective, it exhibits “preferential selectivity„ for COX-2. In this study, the anti-proliferative and apoptotic effects of etodolac and its hydrazone or triazole derivatives (SGK 206 and SGK 242, respectively), were investigated on prostate cancer cell line PC-3 and human colorectal carcinoma cell line HT-29. Our data showed that SGK 206 and SGK 242 were more effective in the inhibition of proliferation and induction of apoptosis compared to etodolac in both cell lines.https://www.mdpi.com/2504-3900/2/25/1573PC-3HT-29etodolaccancerapoptosis |
| spellingShingle | Sevgi Koçyiğit Sevinç Oya Orun Pınar Mega Tiber Pelin Çıkla-Süzgün Ş. Güniz Küçükgüzel Anti-Cancer Acitivity of Etodolac and Its Derivatives on Prostate and Colorectal Cancer Cell Lines Proceedings PC-3 HT-29 etodolac cancer apoptosis |
| title | Anti-Cancer Acitivity of Etodolac and Its Derivatives on Prostate and Colorectal Cancer Cell Lines |
| title_full | Anti-Cancer Acitivity of Etodolac and Its Derivatives on Prostate and Colorectal Cancer Cell Lines |
| title_fullStr | Anti-Cancer Acitivity of Etodolac and Its Derivatives on Prostate and Colorectal Cancer Cell Lines |
| title_full_unstemmed | Anti-Cancer Acitivity of Etodolac and Its Derivatives on Prostate and Colorectal Cancer Cell Lines |
| title_short | Anti-Cancer Acitivity of Etodolac and Its Derivatives on Prostate and Colorectal Cancer Cell Lines |
| title_sort | anti cancer acitivity of etodolac and its derivatives on prostate and colorectal cancer cell lines |
| topic | PC-3 HT-29 etodolac cancer apoptosis |
| url | https://www.mdpi.com/2504-3900/2/25/1573 |
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