Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs
A20 gene variants are linked with systemic sclerosis (SS), but the mechanisms are unclear. Here, the authors show that A20 expression is reduced in SS skin and lungs, that its ablation in mice induces SS, and that show that fibrosis can be ameliorated by induction of A20.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33767-y |
| _version_ | 1811197854001135616 |
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| author | Wenxia Wang Swarna Bale Jun Wei Bharath Yalavarthi Dibyendu Bhattacharyya Jing Jing Yan Hiam Abdala-Valencia Dan Xu Hanshi Sun Roberta G. Marangoni Erica Herzog Sergejs Berdnikovs Stephen D. Miller Amr H. Sawalha Pei-Suen Tsou Kentaro Awaji Takashi Yamashita Shinichi Sato Yoshihide Asano Chinnaswamy Tiruppathi Anjana Yeldandi Bettina C. Schock Swati Bhattacharyya John Varga |
| author_facet | Wenxia Wang Swarna Bale Jun Wei Bharath Yalavarthi Dibyendu Bhattacharyya Jing Jing Yan Hiam Abdala-Valencia Dan Xu Hanshi Sun Roberta G. Marangoni Erica Herzog Sergejs Berdnikovs Stephen D. Miller Amr H. Sawalha Pei-Suen Tsou Kentaro Awaji Takashi Yamashita Shinichi Sato Yoshihide Asano Chinnaswamy Tiruppathi Anjana Yeldandi Bettina C. Schock Swati Bhattacharyya John Varga |
| author_sort | Wenxia Wang |
| collection | DOAJ |
| description | A20 gene variants are linked with systemic sclerosis (SS), but the mechanisms are unclear. Here, the authors show that A20 expression is reduced in SS skin and lungs, that its ablation in mice induces SS, and that show that fibrosis can be ameliorated by induction of A20. |
| first_indexed | 2024-04-12T01:20:02Z |
| format | Article |
| id | doaj.art-b780d1905dd3456085e57175c8dc1c29 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T01:20:02Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b780d1905dd3456085e57175c8dc1c292022-12-22T03:53:48ZengNature PortfolioNature Communications2041-17232022-10-0113111610.1038/s41467-022-33767-yFibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organsWenxia Wang0Swarna Bale1Jun Wei2Bharath Yalavarthi3Dibyendu Bhattacharyya4Jing Jing Yan5Hiam Abdala-Valencia6Dan Xu7Hanshi Sun8Roberta G. Marangoni9Erica Herzog10Sergejs Berdnikovs11Stephen D. Miller12Amr H. Sawalha13Pei-Suen Tsou14Kentaro Awaji15Takashi Yamashita16Shinichi Sato17Yoshihide Asano18Chinnaswamy Tiruppathi19Anjana Yeldandi20Bettina C. Schock21Swati Bhattacharyya22John Varga23Northwestern Scleroderma Program, Department of Medicine, Feinberg School of MedicineNorthwestern Scleroderma Program, Department of Medicine, Feinberg School of MedicineNorthwestern Scleroderma Program, Department of Medicine, Feinberg School of MedicineMichigan Scleroderma Program, Department of Internal Medicine, University of MichiganMichigan Scleroderma Program, Department of Internal Medicine, University of MichiganNorthwestern Scleroderma Program, Department of Medicine, Feinberg School of MedicineDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern UniversityDepartment of Microbiology-Immunology, Northwestern University Feinberg School of MedicineMichigan Scleroderma Program, Department of Internal Medicine, University of MichiganNorthwestern Scleroderma Program, Department of Medicine, Feinberg School of MedicineDepartment of Medicine, Yale University School of MedicineDivision of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of MedicineDepartment of Microbiology-Immunology, Northwestern University Feinberg School of MedicineDepartment of Medicine, University of Pittsburgh School of MedicineMichigan Scleroderma Program, Department of Internal Medicine, University of MichiganDepartment of Dermatology, University of Tokyo Graduate School of MedicineDepartment of Dermatology, University of Tokyo Graduate School of MedicineDepartment of Dermatology, University of Tokyo Graduate School of MedicineDepartment of Dermatology, University of Tokyo Graduate School of MedicineDepartment of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of IllinoisDepartment of Pathology, Feinberg School of Medicine, Northwestern UniversityWellcome-Wolfson Institute for Experimental Medicine, Queens University BelfastNorthwestern Scleroderma Program, Department of Medicine, Feinberg School of MedicineNorthwestern Scleroderma Program, Department of Medicine, Feinberg School of MedicineA20 gene variants are linked with systemic sclerosis (SS), but the mechanisms are unclear. Here, the authors show that A20 expression is reduced in SS skin and lungs, that its ablation in mice induces SS, and that show that fibrosis can be ameliorated by induction of A20.https://doi.org/10.1038/s41467-022-33767-y |
| spellingShingle | Wenxia Wang Swarna Bale Jun Wei Bharath Yalavarthi Dibyendu Bhattacharyya Jing Jing Yan Hiam Abdala-Valencia Dan Xu Hanshi Sun Roberta G. Marangoni Erica Herzog Sergejs Berdnikovs Stephen D. Miller Amr H. Sawalha Pei-Suen Tsou Kentaro Awaji Takashi Yamashita Shinichi Sato Yoshihide Asano Chinnaswamy Tiruppathi Anjana Yeldandi Bettina C. Schock Swati Bhattacharyya John Varga Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs Nature Communications |
| title | Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs |
| title_full | Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs |
| title_fullStr | Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs |
| title_full_unstemmed | Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs |
| title_short | Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs |
| title_sort | fibroblast a20 governs fibrosis susceptibility and its repression by dream promotes fibrosis in multiple organs |
| url | https://doi.org/10.1038/s41467-022-33767-y |
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