Features of structure and dynamics in damages of fertile properties in ejaculate under the influence of toxocariasis invasion
Purpose of the study. To study the features of changes of spermiologic values and degree of spermatozoa DNA fragmentation depending on the presence/absence of toxocariasis invasion. Materials and methods. 89 men aged 20 to 45 years were examined, which were divided into 5 groups. The first (contr...
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| Format: | Article |
| Language: | English |
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Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine
2020-12-01
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| Series: | Сучасні медичні технології |
| Subjects: | |
| Online Access: | https://zmapo-journal.com/index.php/journal/article/view/99 |
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| author | L. L. Voroncova S. O. Kenijz V. A. Kovalenko |
| author_facet | L. L. Voroncova S. O. Kenijz V. A. Kovalenko |
| author_sort | L. L. Voroncova |
| collection | DOAJ |
| description | Purpose of the study. To study the features of changes of spermiologic values and degree of spermatozoa DNA fragmentation depending on the presence/absence of toxocariasis invasion.
Materials and methods. 89 men aged 20 to 45 years were examined, which were divided into 5 groups. The first (control) group was 12 fertile men; the second group (comparison group) – 27 infertility patients with normal level of DNA fragmentation of sperm and without antibodies to toxocariasis; The third group – 20 infertility men with normal level of DNA fragmentation of sperm and presence of antibodies to toxocariasis. By the fourth and fifth groups included 15 infertility men with high levels of DNA fragmentation of sperm and the presence of antibodies to toxocariasis and lack of respectively. A comprehensive research was conducted for all men that included analysis of spermogram according to WHO recommendations, determination of sperm DNA fragmentation and presence of toxocariasis invasion.
Results. As a result of spermograms in the studied groups of men were identified the violations of ejaculate fertility (asteno-, teratoand oligozoospermia). It has been established that the degree disturbance of spermatogenesis (including significant oligoand teratozoospermia) is depending on the fragmentation of DNA in male gametes and the presence of antibodies to toxocara. At the same time more severe patozoospermia observed in the presence of elevated levels of fragmented sperms and the absence of antibodies to toxocara antigens, which is the basis for further research.
Conclusions. Thus, the determination of sperm DNA fragmentation and availability of toxocariasis invasion in men with reproductive disorders is a necessary component of a comprehensive examination, which may allow to improve the diagnostics of male infertility and to promote the development of the right tactics and optimal treatment regimens. |
| first_indexed | 2024-04-12T13:23:12Z |
| format | Article |
| id | doaj.art-b7838d6c541c46e1809f66a897b80013 |
| institution | Directory Open Access Journal |
| issn | 2072-9367 |
| language | English |
| last_indexed | 2024-04-12T13:23:12Z |
| publishDate | 2020-12-01 |
| publisher | Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine |
| record_format | Article |
| series | Сучасні медичні технології |
| spelling | doaj.art-b7838d6c541c46e1809f66a897b800132022-12-22T03:31:25ZengZaporizhia Medical Academy of Post-Graduate Education Ministry of Health of UkraineСучасні медичні технології2072-93672020-12-014(47)121710.34287/MMT.4(47).2020.299Features of structure and dynamics in damages of fertile properties in ejaculate under the influence of toxocariasis invasionL. L. Voroncova0S. O. Kenijz1V. A. Kovalenko2State institution "Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine"State institution "Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine"State institution "Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine"Purpose of the study. To study the features of changes of spermiologic values and degree of spermatozoa DNA fragmentation depending on the presence/absence of toxocariasis invasion. Materials and methods. 89 men aged 20 to 45 years were examined, which were divided into 5 groups. The first (control) group was 12 fertile men; the second group (comparison group) – 27 infertility patients with normal level of DNA fragmentation of sperm and without antibodies to toxocariasis; The third group – 20 infertility men with normal level of DNA fragmentation of sperm and presence of antibodies to toxocariasis. By the fourth and fifth groups included 15 infertility men with high levels of DNA fragmentation of sperm and the presence of antibodies to toxocariasis and lack of respectively. A comprehensive research was conducted for all men that included analysis of spermogram according to WHO recommendations, determination of sperm DNA fragmentation and presence of toxocariasis invasion. Results. As a result of spermograms in the studied groups of men were identified the violations of ejaculate fertility (asteno-, teratoand oligozoospermia). It has been established that the degree disturbance of spermatogenesis (including significant oligoand teratozoospermia) is depending on the fragmentation of DNA in male gametes and the presence of antibodies to toxocara. At the same time more severe patozoospermia observed in the presence of elevated levels of fragmented sperms and the absence of antibodies to toxocara antigens, which is the basis for further research. Conclusions. Thus, the determination of sperm DNA fragmentation and availability of toxocariasis invasion in men with reproductive disorders is a necessary component of a comprehensive examination, which may allow to improve the diagnostics of male infertility and to promote the development of the right tactics and optimal treatment regimens.https://zmapo-journal.com/index.php/journal/article/view/99male infertilityspermogramsperm dna fragmentationtoxocariasis invasion |
| spellingShingle | L. L. Voroncova S. O. Kenijz V. A. Kovalenko Features of structure and dynamics in damages of fertile properties in ejaculate under the influence of toxocariasis invasion Сучасні медичні технології male infertility spermogram sperm dna fragmentation toxocariasis invasion |
| title | Features of structure and dynamics in damages of fertile properties in ejaculate under the influence of toxocariasis invasion |
| title_full | Features of structure and dynamics in damages of fertile properties in ejaculate under the influence of toxocariasis invasion |
| title_fullStr | Features of structure and dynamics in damages of fertile properties in ejaculate under the influence of toxocariasis invasion |
| title_full_unstemmed | Features of structure and dynamics in damages of fertile properties in ejaculate under the influence of toxocariasis invasion |
| title_short | Features of structure and dynamics in damages of fertile properties in ejaculate under the influence of toxocariasis invasion |
| title_sort | features of structure and dynamics in damages of fertile properties in ejaculate under the influence of toxocariasis invasion |
| topic | male infertility spermogram sperm dna fragmentation toxocariasis invasion |
| url | https://zmapo-journal.com/index.php/journal/article/view/99 |
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