A Bibliometric Analysis of Cyclophosphamide, Methotrexate, and Fluorouracil Breast Cancer Treatments: Implication for the Role of Inflammation in Cognitive Dysfunction
Inflammation is considered one of the possible mechanisms behind long-term cognitive dysfunction persistent after chemotherapy treatment. The chemotherapy combination of cyclophosphamide, methotrexate, and fluorouracil (CMF) was one of the older methods of treating breast cancer patients. Decades la...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-08-01
|
| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.683389/full |
| _version_ | 1818458144265732096 |
|---|---|
| author | Christa Corley Christa Corley Antiño R. Allen Antiño R. Allen Antiño R. Allen |
| author_facet | Christa Corley Christa Corley Antiño R. Allen Antiño R. Allen Antiño R. Allen |
| author_sort | Christa Corley |
| collection | DOAJ |
| description | Inflammation is considered one of the possible mechanisms behind long-term cognitive dysfunction persistent after chemotherapy treatment. The chemotherapy combination of cyclophosphamide, methotrexate, and fluorouracil (CMF) was one of the older methods of treating breast cancer patients. Decades later, these patients still report experiencing cognitive side effects. In this present bibliometric review, we applied the VOSviewer tool to describe the existing landscape on literature concerning inflammation as it relates to CMF and cognitive dysfunctions. As time progressed, we saw an increase in interest in the topic. By the mid-2010s there were approximately 1,000 publications per year. Terms related to the brain and CNS did not appear until the later years, and terms related to inflammation and breast cancer were very prevalent throughout the three decades. Also, in more recent years, inflammatory markers and plant-derived compounds used to alleviate side effects of the inflammatory response appeared in the search results. The USA remained the most prolific producer of CMF-, inflammation-, and cognitive dysfunction-related papers throughout the three decades followed by Asia and Europe. As research of cognitive dysfunction caused by inflammation due to chemotherapy treatment progresses, more opportunities emerge for therapeutic methods to improve the quality of life for long-term survivors. |
| first_indexed | 2024-12-14T22:53:47Z |
| format | Article |
| id | doaj.art-b784f04e00314145b1360ec2cafc0c31 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-14T22:53:47Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-b784f04e00314145b1360ec2cafc0c312022-12-21T22:44:38ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-08-01810.3389/fmolb.2021.683389683389A Bibliometric Analysis of Cyclophosphamide, Methotrexate, and Fluorouracil Breast Cancer Treatments: Implication for the Role of Inflammation in Cognitive DysfunctionChrista Corley0Christa Corley1Antiño R. Allen2Antiño R. Allen3Antiño R. Allen4Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, AR, United StatesDepartment of Pharmaceutical Sciences, The University of Arkansas for Medical Sciences, Little Rock, AR, United StatesDivision of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, AR, United StatesDepartment of Pharmaceutical Sciences, The University of Arkansas for Medical Sciences, Little Rock, AR, United StatesNeurobiology & Developmental Sciences, The University of Arkansas for Medical Sciences, Little Rock, AR, United StatesInflammation is considered one of the possible mechanisms behind long-term cognitive dysfunction persistent after chemotherapy treatment. The chemotherapy combination of cyclophosphamide, methotrexate, and fluorouracil (CMF) was one of the older methods of treating breast cancer patients. Decades later, these patients still report experiencing cognitive side effects. In this present bibliometric review, we applied the VOSviewer tool to describe the existing landscape on literature concerning inflammation as it relates to CMF and cognitive dysfunctions. As time progressed, we saw an increase in interest in the topic. By the mid-2010s there were approximately 1,000 publications per year. Terms related to the brain and CNS did not appear until the later years, and terms related to inflammation and breast cancer were very prevalent throughout the three decades. Also, in more recent years, inflammatory markers and plant-derived compounds used to alleviate side effects of the inflammatory response appeared in the search results. The USA remained the most prolific producer of CMF-, inflammation-, and cognitive dysfunction-related papers throughout the three decades followed by Asia and Europe. As research of cognitive dysfunction caused by inflammation due to chemotherapy treatment progresses, more opportunities emerge for therapeutic methods to improve the quality of life for long-term survivors.https://www.frontiersin.org/articles/10.3389/fmolb.2021.683389/fullcyclophosphamidemethotrexatefluorouracilbraininflammation |
| spellingShingle | Christa Corley Christa Corley Antiño R. Allen Antiño R. Allen Antiño R. Allen A Bibliometric Analysis of Cyclophosphamide, Methotrexate, and Fluorouracil Breast Cancer Treatments: Implication for the Role of Inflammation in Cognitive Dysfunction Frontiers in Molecular Biosciences cyclophosphamide methotrexate fluorouracil brain inflammation |
| title | A Bibliometric Analysis of Cyclophosphamide, Methotrexate, and Fluorouracil Breast Cancer Treatments: Implication for the Role of Inflammation in Cognitive Dysfunction |
| title_full | A Bibliometric Analysis of Cyclophosphamide, Methotrexate, and Fluorouracil Breast Cancer Treatments: Implication for the Role of Inflammation in Cognitive Dysfunction |
| title_fullStr | A Bibliometric Analysis of Cyclophosphamide, Methotrexate, and Fluorouracil Breast Cancer Treatments: Implication for the Role of Inflammation in Cognitive Dysfunction |
| title_full_unstemmed | A Bibliometric Analysis of Cyclophosphamide, Methotrexate, and Fluorouracil Breast Cancer Treatments: Implication for the Role of Inflammation in Cognitive Dysfunction |
| title_short | A Bibliometric Analysis of Cyclophosphamide, Methotrexate, and Fluorouracil Breast Cancer Treatments: Implication for the Role of Inflammation in Cognitive Dysfunction |
| title_sort | bibliometric analysis of cyclophosphamide methotrexate and fluorouracil breast cancer treatments implication for the role of inflammation in cognitive dysfunction |
| topic | cyclophosphamide methotrexate fluorouracil brain inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.683389/full |
| work_keys_str_mv | AT christacorley abibliometricanalysisofcyclophosphamidemethotrexateandfluorouracilbreastcancertreatmentsimplicationfortheroleofinflammationincognitivedysfunction AT christacorley abibliometricanalysisofcyclophosphamidemethotrexateandfluorouracilbreastcancertreatmentsimplicationfortheroleofinflammationincognitivedysfunction AT antinorallen abibliometricanalysisofcyclophosphamidemethotrexateandfluorouracilbreastcancertreatmentsimplicationfortheroleofinflammationincognitivedysfunction AT antinorallen abibliometricanalysisofcyclophosphamidemethotrexateandfluorouracilbreastcancertreatmentsimplicationfortheroleofinflammationincognitivedysfunction AT antinorallen abibliometricanalysisofcyclophosphamidemethotrexateandfluorouracilbreastcancertreatmentsimplicationfortheroleofinflammationincognitivedysfunction AT christacorley bibliometricanalysisofcyclophosphamidemethotrexateandfluorouracilbreastcancertreatmentsimplicationfortheroleofinflammationincognitivedysfunction AT christacorley bibliometricanalysisofcyclophosphamidemethotrexateandfluorouracilbreastcancertreatmentsimplicationfortheroleofinflammationincognitivedysfunction AT antinorallen bibliometricanalysisofcyclophosphamidemethotrexateandfluorouracilbreastcancertreatmentsimplicationfortheroleofinflammationincognitivedysfunction AT antinorallen bibliometricanalysisofcyclophosphamidemethotrexateandfluorouracilbreastcancertreatmentsimplicationfortheroleofinflammationincognitivedysfunction AT antinorallen bibliometricanalysisofcyclophosphamidemethotrexateandfluorouracilbreastcancertreatmentsimplicationfortheroleofinflammationincognitivedysfunction |