Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models

Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models

Abstract Background Atsttrin, an engineered protein composed of three tumor necrosis factor receptor (TNFR)-binding fragments of progranulin (PGRN), shows therapeutic effect in multiple murine models of inflammatory arthritis . Additionally, intra-articular delivery of PGRN protects against osteoart...

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Bibliographic Details
Main Authors: Jian-lu Wei, Wenyu Fu, Yuan-jing Ding, Aubryanna Hettinghouse, Matin Lendhey, Ran Schwarzkopf, Oran D. Kennedy, Chuan-ju Liu
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Arthritis Research & Therapy
Subjects:
Atsttrin
Progranulin
TNFα
TNFR2
TNFR1
Osteoarthritis
Online Access:http://link.springer.com/article/10.1186/s13075-017-1485-8

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