Relationship between non-culprit lesion plaque characteristics changes and in-stent neoatherosclerosis formation: 1-year follow-up optical coherence tomography study

The relationship between the in-stent neoatherosclerosis (ISNA) formation and the plaque’s characteristic changes in the non-culprit lesion is unclear. We aim to investigate the plaque characteristics changes at non-culprit lesions between patients with ISNA and without ISNA formation at 1-year f...

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Main Authors: Lei Xing, Yongpeng Zou, Chao Fu, Xiaoying Fan, Xuedong Wang, Qi Liu, Mengyue Yang, Dandan Liu, Linxing Feng, Jingbo Hou, Xingtao Huang
Format: Article
Language:English
Published: IMR Press 2021-12-01
Series:Reviews in Cardiovascular Medicine
Subjects:
Online Access:https://rcm.imrpress.com/EN/10.31083/j.rcm2204177
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author Lei Xing
Yongpeng Zou
Chao Fu
Xiaoying Fan
Xuedong Wang
Qi Liu
Mengyue Yang
Dandan Liu
Linxing Feng
Jingbo Hou
Xingtao Huang
author_facet Lei Xing
Yongpeng Zou
Chao Fu
Xiaoying Fan
Xuedong Wang
Qi Liu
Mengyue Yang
Dandan Liu
Linxing Feng
Jingbo Hou
Xingtao Huang
author_sort Lei Xing
collection DOAJ
description The relationship between the in-stent neoatherosclerosis (ISNA) formation and the plaque’s characteristic changes in the non-culprit lesion is unclear. We aim to investigate the plaque characteristics changes at non-culprit lesions between patients with ISNA and without ISNA formation at 1-year follow-up. We retrospectively enrolled patients who had DES implantation in de novo lesion and underwent immediately after stenting and 1-year follow-up optical coherence tomography (OCT) examination. OCT-defined ISNA was defined as the presence of lipid-laden neointima or calcification within the culprit stent with a longitudinal extension of ≥1 mm. Non-culprit lesions were divided into two groups: ISNA group (with ISNA) and non-ISNA group (without ISNA). Plaque characteristics of non-culprit lesions were evaluated at baseline and 1-year follow-up. In total, 89 patients with 89 non-culprit lesions (ISNA: n = 37; non-ISNA: n = 52) were included in the analyses. The lesions in the ISNA group show a smaller minimum lumen area compared to the non-ISNA group at 1-year follow-up (2.57 ± 1.08 mm2 versus 3.20 ± 1.62 mm2, p = 0.044). The lesions of the ISNA group show a significant decrease in minimum lumen area changes percent (–7.25% versus 6.46%, p = 0.039). And there are more lesions with minimum lumen area (64.9% versus 38.5%, p = 0.014) and minimum lumen diameter (64.9% versus 40.4%, p = 0.023) decrease in the ISNA group. Furthermore, the lesions in ISNA group have more plaques with lipid core length increase (25.0% versus 10.0%, p = 0.040), more plaques with FCT decrease (50.0% versus 74.0%, p = 0.027) and less TCFA change to non-TCFA (33.3% versus 87.5%, p = 0.010). The plaque characteristic changes in non-culprit lesions are closely related to ISNA formation. The ISNA formation may accompany by a tardier plaque stabilization process in non-culprit lesions.
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spelling doaj.art-b785930253c04bf897072c044fb800282022-12-22T01:39:52ZengIMR PressReviews in Cardiovascular Medicine2153-81742021-12-012241693170010.31083/j.rcm2204177S1530-6550(21)00230-1Relationship between non-culprit lesion plaque characteristics changes and in-stent neoatherosclerosis formation: 1-year follow-up optical coherence tomography studyLei Xing0Yongpeng Zou1Chao Fu2Xiaoying Fan3Xuedong Wang4Qi Liu5Mengyue Yang6Dandan Liu7Linxing Feng8Jingbo Hou9Xingtao Huang10Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 150000 Harbin, Heilongjiang, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 150000 Harbin, Heilongjiang, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 150000 Harbin, Heilongjiang, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 150000 Harbin, Heilongjiang, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 150000 Harbin, Heilongjiang, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 150000 Harbin, Heilongjiang, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 150000 Harbin, Heilongjiang, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 150000 Harbin, Heilongjiang, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 150000 Harbin, Heilongjiang, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 150000 Harbin, Heilongjiang, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 150000 Harbin, Heilongjiang, ChinaThe relationship between the in-stent neoatherosclerosis (ISNA) formation and the plaque’s characteristic changes in the non-culprit lesion is unclear. We aim to investigate the plaque characteristics changes at non-culprit lesions between patients with ISNA and without ISNA formation at 1-year follow-up. We retrospectively enrolled patients who had DES implantation in de novo lesion and underwent immediately after stenting and 1-year follow-up optical coherence tomography (OCT) examination. OCT-defined ISNA was defined as the presence of lipid-laden neointima or calcification within the culprit stent with a longitudinal extension of ≥1 mm. Non-culprit lesions were divided into two groups: ISNA group (with ISNA) and non-ISNA group (without ISNA). Plaque characteristics of non-culprit lesions were evaluated at baseline and 1-year follow-up. In total, 89 patients with 89 non-culprit lesions (ISNA: n = 37; non-ISNA: n = 52) were included in the analyses. The lesions in the ISNA group show a smaller minimum lumen area compared to the non-ISNA group at 1-year follow-up (2.57 ± 1.08 mm2 versus 3.20 ± 1.62 mm2, p = 0.044). The lesions of the ISNA group show a significant decrease in minimum lumen area changes percent (–7.25% versus 6.46%, p = 0.039). And there are more lesions with minimum lumen area (64.9% versus 38.5%, p = 0.014) and minimum lumen diameter (64.9% versus 40.4%, p = 0.023) decrease in the ISNA group. Furthermore, the lesions in ISNA group have more plaques with lipid core length increase (25.0% versus 10.0%, p = 0.040), more plaques with FCT decrease (50.0% versus 74.0%, p = 0.027) and less TCFA change to non-TCFA (33.3% versus 87.5%, p = 0.010). The plaque characteristic changes in non-culprit lesions are closely related to ISNA formation. The ISNA formation may accompany by a tardier plaque stabilization process in non-culprit lesions.https://rcm.imrpress.com/EN/10.31083/j.rcm2204177optical coherence tomographyneoatherosclerosisnon-culprit lesion
spellingShingle Lei Xing
Yongpeng Zou
Chao Fu
Xiaoying Fan
Xuedong Wang
Qi Liu
Mengyue Yang
Dandan Liu
Linxing Feng
Jingbo Hou
Xingtao Huang
Relationship between non-culprit lesion plaque characteristics changes and in-stent neoatherosclerosis formation: 1-year follow-up optical coherence tomography study
Reviews in Cardiovascular Medicine
optical coherence tomography
neoatherosclerosis
non-culprit lesion
title Relationship between non-culprit lesion plaque characteristics changes and in-stent neoatherosclerosis formation: 1-year follow-up optical coherence tomography study
title_full Relationship between non-culprit lesion plaque characteristics changes and in-stent neoatherosclerosis formation: 1-year follow-up optical coherence tomography study
title_fullStr Relationship between non-culprit lesion plaque characteristics changes and in-stent neoatherosclerosis formation: 1-year follow-up optical coherence tomography study
title_full_unstemmed Relationship between non-culprit lesion plaque characteristics changes and in-stent neoatherosclerosis formation: 1-year follow-up optical coherence tomography study
title_short Relationship between non-culprit lesion plaque characteristics changes and in-stent neoatherosclerosis formation: 1-year follow-up optical coherence tomography study
title_sort relationship between non culprit lesion plaque characteristics changes and in stent neoatherosclerosis formation 1 year follow up optical coherence tomography study
topic optical coherence tomography
neoatherosclerosis
non-culprit lesion
url https://rcm.imrpress.com/EN/10.31083/j.rcm2204177
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