Relationship between non-culprit lesion plaque characteristics changes and in-stent neoatherosclerosis formation: 1-year follow-up optical coherence tomography study
The relationship between the in-stent neoatherosclerosis (ISNA) formation and the plaque’s characteristic changes in the non-culprit lesion is unclear. We aim to investigate the plaque characteristics changes at non-culprit lesions between patients with ISNA and without ISNA formation at 1-year f...
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IMR Press
2021-12-01
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Series: | Reviews in Cardiovascular Medicine |
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Online Access: | https://rcm.imrpress.com/EN/10.31083/j.rcm2204177 |
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author | Lei Xing Yongpeng Zou Chao Fu Xiaoying Fan Xuedong Wang Qi Liu Mengyue Yang Dandan Liu Linxing Feng Jingbo Hou Xingtao Huang |
author_facet | Lei Xing Yongpeng Zou Chao Fu Xiaoying Fan Xuedong Wang Qi Liu Mengyue Yang Dandan Liu Linxing Feng Jingbo Hou Xingtao Huang |
author_sort | Lei Xing |
collection | DOAJ |
description | The relationship between the in-stent neoatherosclerosis (ISNA) formation and
the plaque’s characteristic changes in the non-culprit lesion is unclear. We aim
to investigate the plaque characteristics changes at non-culprit lesions between
patients with ISNA and without ISNA formation at 1-year follow-up. We
retrospectively enrolled patients who had DES implantation in de novo lesion and
underwent immediately after stenting and 1-year follow-up optical coherence
tomography (OCT) examination. OCT-defined ISNA was defined as the presence of
lipid-laden neointima or calcification within the culprit stent with a
longitudinal extension of ≥1 mm. Non-culprit lesions were divided into two
groups: ISNA group (with ISNA) and non-ISNA group (without ISNA). Plaque
characteristics of non-culprit lesions were evaluated at baseline and 1-year
follow-up. In total, 89 patients with 89 non-culprit lesions (ISNA: n = 37;
non-ISNA: n = 52) were included in the analyses. The lesions in the ISNA group
show a smaller minimum lumen area compared to the non-ISNA group at 1-year
follow-up (2.57 ± 1.08 mm2 versus 3.20 ± 1.62 mm2,
p = 0.044). The lesions of the ISNA group show a significant decrease in
minimum lumen area changes percent (–7.25% versus 6.46%, p = 0.039).
And there are more lesions with minimum lumen area (64.9% versus 38.5%,
p = 0.014) and minimum lumen diameter (64.9% versus 40.4%, p
= 0.023) decrease in the ISNA group. Furthermore, the lesions in ISNA group have
more plaques with lipid core length increase (25.0% versus 10.0%, p =
0.040), more plaques with FCT decrease (50.0% versus 74.0%, p = 0.027)
and less TCFA change to non-TCFA (33.3% versus 87.5%, p = 0.010). The
plaque characteristic changes in non-culprit lesions are closely related to ISNA
formation. The ISNA formation may accompany by a tardier plaque stabilization
process in non-culprit lesions. |
first_indexed | 2024-12-10T17:24:49Z |
format | Article |
id | doaj.art-b785930253c04bf897072c044fb80028 |
institution | Directory Open Access Journal |
issn | 2153-8174 |
language | English |
last_indexed | 2024-12-10T17:24:49Z |
publishDate | 2021-12-01 |
publisher | IMR Press |
record_format | Article |
series | Reviews in Cardiovascular Medicine |
spelling | doaj.art-b785930253c04bf897072c044fb800282022-12-22T01:39:52ZengIMR PressReviews in Cardiovascular Medicine2153-81742021-12-012241693170010.31083/j.rcm2204177S1530-6550(21)00230-1Relationship between non-culprit lesion plaque characteristics changes and in-stent neoatherosclerosis formation: 1-year follow-up optical coherence tomography studyLei Xing0Yongpeng Zou1Chao Fu2Xiaoying Fan3Xuedong Wang4Qi Liu5Mengyue Yang6Dandan Liu7Linxing Feng8Jingbo Hou9Xingtao Huang10Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 150000 Harbin, Heilongjiang, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 150000 Harbin, Heilongjiang, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 150000 Harbin, Heilongjiang, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 150000 Harbin, Heilongjiang, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 150000 Harbin, Heilongjiang, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 150000 Harbin, Heilongjiang, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 150000 Harbin, Heilongjiang, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 150000 Harbin, Heilongjiang, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 150000 Harbin, Heilongjiang, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 150000 Harbin, Heilongjiang, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, 150000 Harbin, Heilongjiang, ChinaThe relationship between the in-stent neoatherosclerosis (ISNA) formation and the plaque’s characteristic changes in the non-culprit lesion is unclear. We aim to investigate the plaque characteristics changes at non-culprit lesions between patients with ISNA and without ISNA formation at 1-year follow-up. We retrospectively enrolled patients who had DES implantation in de novo lesion and underwent immediately after stenting and 1-year follow-up optical coherence tomography (OCT) examination. OCT-defined ISNA was defined as the presence of lipid-laden neointima or calcification within the culprit stent with a longitudinal extension of ≥1 mm. Non-culprit lesions were divided into two groups: ISNA group (with ISNA) and non-ISNA group (without ISNA). Plaque characteristics of non-culprit lesions were evaluated at baseline and 1-year follow-up. In total, 89 patients with 89 non-culprit lesions (ISNA: n = 37; non-ISNA: n = 52) were included in the analyses. The lesions in the ISNA group show a smaller minimum lumen area compared to the non-ISNA group at 1-year follow-up (2.57 ± 1.08 mm2 versus 3.20 ± 1.62 mm2, p = 0.044). The lesions of the ISNA group show a significant decrease in minimum lumen area changes percent (–7.25% versus 6.46%, p = 0.039). And there are more lesions with minimum lumen area (64.9% versus 38.5%, p = 0.014) and minimum lumen diameter (64.9% versus 40.4%, p = 0.023) decrease in the ISNA group. Furthermore, the lesions in ISNA group have more plaques with lipid core length increase (25.0% versus 10.0%, p = 0.040), more plaques with FCT decrease (50.0% versus 74.0%, p = 0.027) and less TCFA change to non-TCFA (33.3% versus 87.5%, p = 0.010). The plaque characteristic changes in non-culprit lesions are closely related to ISNA formation. The ISNA formation may accompany by a tardier plaque stabilization process in non-culprit lesions.https://rcm.imrpress.com/EN/10.31083/j.rcm2204177optical coherence tomographyneoatherosclerosisnon-culprit lesion |
spellingShingle | Lei Xing Yongpeng Zou Chao Fu Xiaoying Fan Xuedong Wang Qi Liu Mengyue Yang Dandan Liu Linxing Feng Jingbo Hou Xingtao Huang Relationship between non-culprit lesion plaque characteristics changes and in-stent neoatherosclerosis formation: 1-year follow-up optical coherence tomography study Reviews in Cardiovascular Medicine optical coherence tomography neoatherosclerosis non-culprit lesion |
title | Relationship between non-culprit lesion plaque characteristics changes and in-stent neoatherosclerosis formation: 1-year follow-up optical coherence tomography study |
title_full | Relationship between non-culprit lesion plaque characteristics changes and in-stent neoatherosclerosis formation: 1-year follow-up optical coherence tomography study |
title_fullStr | Relationship between non-culprit lesion plaque characteristics changes and in-stent neoatherosclerosis formation: 1-year follow-up optical coherence tomography study |
title_full_unstemmed | Relationship between non-culprit lesion plaque characteristics changes and in-stent neoatherosclerosis formation: 1-year follow-up optical coherence tomography study |
title_short | Relationship between non-culprit lesion plaque characteristics changes and in-stent neoatherosclerosis formation: 1-year follow-up optical coherence tomography study |
title_sort | relationship between non culprit lesion plaque characteristics changes and in stent neoatherosclerosis formation 1 year follow up optical coherence tomography study |
topic | optical coherence tomography neoatherosclerosis non-culprit lesion |
url | https://rcm.imrpress.com/EN/10.31083/j.rcm2204177 |
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