Current Concepts and Future Trends in Increasing the Benefits of Cochlear Implantation: A Narrative Review
Hearing loss is the most common neurosensory disorder, and with the constant increase in etiological factors, combined with early detection protocols, numbers will continue to rise. Cochlear implantation has become the gold standard for patients with severe hearing loss, and interest has shifted fro...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/6/747 |
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| author | Cristina Maria Blebea Laszlo Peter Ujvary Violeta Necula Maximilian George Dindelegan Maria Perde-Schrepler Mirela Cristina Stamate Marcel Cosgarea Alma Aurelia Maniu |
| author_facet | Cristina Maria Blebea Laszlo Peter Ujvary Violeta Necula Maximilian George Dindelegan Maria Perde-Schrepler Mirela Cristina Stamate Marcel Cosgarea Alma Aurelia Maniu |
| author_sort | Cristina Maria Blebea |
| collection | DOAJ |
| description | Hearing loss is the most common neurosensory disorder, and with the constant increase in etiological factors, combined with early detection protocols, numbers will continue to rise. Cochlear implantation has become the gold standard for patients with severe hearing loss, and interest has shifted from implantation principles to the preservation of residual hearing following the procedure itself. As the audiological criteria for cochlear implant eligibility have expanded to include patients with good residual hearing, more attention is focused on complementary development of otoprotective agents, electrode design, and surgical approaches. The focus of this review is current aspects of preserving residual hearing through a summary of recent trends regarding surgical and pharmacological fundamentals. Subsequently, the assessment of new pharmacological options, novel bioactive molecules (neurotrophins, growth factors, etc.), nanoparticles, stem cells, and gene therapy are discussed. |
| first_indexed | 2024-03-09T23:07:10Z |
| format | Article |
| id | doaj.art-b7890cf26173466fb02f644996386a13 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T23:07:10Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-b7890cf26173466fb02f644996386a132023-11-23T17:51:53ZengMDPI AGMedicina1010-660X1648-91442022-05-0158674710.3390/medicina58060747Current Concepts and Future Trends in Increasing the Benefits of Cochlear Implantation: A Narrative ReviewCristina Maria Blebea0Laszlo Peter Ujvary1Violeta Necula2Maximilian George Dindelegan3Maria Perde-Schrepler4Mirela Cristina Stamate5Marcel Cosgarea6Alma Aurelia Maniu7Department of Otorhinolaryngology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400347 Cluj Napoca, RomaniaDepartment of Otorhinolaryngology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400347 Cluj Napoca, RomaniaDepartment of Otorhinolaryngology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400347 Cluj Napoca, RomaniaDepartment of Otorhinolaryngology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400347 Cluj Napoca, RomaniaInstitute of Oncology “Prof.Dr. Ion Chiricuta”, 400015 Cluj Napoca, RomaniaDepartment of Otorhinolaryngology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400347 Cluj Napoca, RomaniaDepartment of Otorhinolaryngology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400347 Cluj Napoca, RomaniaDepartment of Otorhinolaryngology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400347 Cluj Napoca, RomaniaHearing loss is the most common neurosensory disorder, and with the constant increase in etiological factors, combined with early detection protocols, numbers will continue to rise. Cochlear implantation has become the gold standard for patients with severe hearing loss, and interest has shifted from implantation principles to the preservation of residual hearing following the procedure itself. As the audiological criteria for cochlear implant eligibility have expanded to include patients with good residual hearing, more attention is focused on complementary development of otoprotective agents, electrode design, and surgical approaches. The focus of this review is current aspects of preserving residual hearing through a summary of recent trends regarding surgical and pharmacological fundamentals. Subsequently, the assessment of new pharmacological options, novel bioactive molecules (neurotrophins, growth factors, etc.), nanoparticles, stem cells, and gene therapy are discussed.https://www.mdpi.com/1648-9144/58/6/747cochlear implanthearing lossdeafnessreviewnanomaterialsdexamethasone |
| spellingShingle | Cristina Maria Blebea Laszlo Peter Ujvary Violeta Necula Maximilian George Dindelegan Maria Perde-Schrepler Mirela Cristina Stamate Marcel Cosgarea Alma Aurelia Maniu Current Concepts and Future Trends in Increasing the Benefits of Cochlear Implantation: A Narrative Review Medicina cochlear implant hearing loss deafness review nanomaterials dexamethasone |
| title | Current Concepts and Future Trends in Increasing the Benefits of Cochlear Implantation: A Narrative Review |
| title_full | Current Concepts and Future Trends in Increasing the Benefits of Cochlear Implantation: A Narrative Review |
| title_fullStr | Current Concepts and Future Trends in Increasing the Benefits of Cochlear Implantation: A Narrative Review |
| title_full_unstemmed | Current Concepts and Future Trends in Increasing the Benefits of Cochlear Implantation: A Narrative Review |
| title_short | Current Concepts and Future Trends in Increasing the Benefits of Cochlear Implantation: A Narrative Review |
| title_sort | current concepts and future trends in increasing the benefits of cochlear implantation a narrative review |
| topic | cochlear implant hearing loss deafness review nanomaterials dexamethasone |
| url | https://www.mdpi.com/1648-9144/58/6/747 |
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