Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy
The eukaryotic host is in close contact to myriads of resident and transient microbes, which influence the crucial physiological pathways. Emerging evidence points to their role of host–microbe interactions for controlling tissue homeostasis, cell fate decisions, and regenerative capacity in epithel...
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| Format: | Artikel |
| Sprache: | English |
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Frontiers Media S.A.
2018-09-01
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| Schriftenreihe: | Frontiers in Microbiology |
| Schlagworte: | |
| Online Zugang: | https://www.frontiersin.org/article/10.3389/fmicb.2018.02020/full |
| _version_ | 1830483616637911040 |
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| author | Jakob von Frieling Christine Fink Jacob Hamm Kenneth Klischies Michael Forster Thomas C. G. Bosch Thomas Roeder Philip Rosenstiel Felix Sommer |
| author_facet | Jakob von Frieling Christine Fink Jacob Hamm Kenneth Klischies Michael Forster Thomas C. G. Bosch Thomas Roeder Philip Rosenstiel Felix Sommer |
| author_sort | Jakob von Frieling |
| collection | DOAJ |
| description | The eukaryotic host is in close contact to myriads of resident and transient microbes, which influence the crucial physiological pathways. Emerging evidence points to their role of host–microbe interactions for controlling tissue homeostasis, cell fate decisions, and regenerative capacity in epithelial barrier organs including the skin, lung, and gut. In humans and mice, it has been shown that the malignant tumors of these organs harbor an altered microbiota. Mechanistic studies have shown that the altered metabolic properties and secreted factors contribute to epithelial carcinogenesis and tumor progression. Exciting recent work points toward a crucial influence of the associated microbial communities on the response to chemotherapy and immune-check point inhibitors during cancer treatment, which suggests that the modulation of the microbiota might be a powerful tool for personalized oncology. In this article, we provide an overview of how the bacterial signals and signatures may influence epithelial homeostasis across taxa from cnidarians to vertebrates and delineate mechanisms, which might be potential targets for therapy of human diseases by either harnessing barrier integrity (infection and inflammation) or restoring uncontrolled proliferation (cancer). |
| first_indexed | 2024-12-21T17:55:26Z |
| format | Article |
| id | doaj.art-b78a193ffbcf415cbede72c13d5f1bcd |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-21T17:55:26Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-b78a193ffbcf415cbede72c13d5f1bcd2022-12-21T18:55:14ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2018-09-01910.3389/fmicb.2018.02020389118Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer TherapyJakob von Frieling0Christine Fink1Jacob Hamm2Kenneth Klischies3Michael Forster4Thomas C. G. Bosch5Thomas Roeder6Philip Rosenstiel7Felix Sommer8Zoological Institute, Christian-Albrechts-Universität zu Kiel, Kiel, GermanyZoological Institute, Christian-Albrechts-Universität zu Kiel, Kiel, GermanyInstitute of Clinical Molecular Biology, Christian-Albrechts-Universität zu Kiel, Kiel, GermanyInstitute of Clinical Molecular Biology, Christian-Albrechts-Universität zu Kiel, Kiel, GermanyInstitute of Clinical Molecular Biology, Christian-Albrechts-Universität zu Kiel, Kiel, GermanyZoological Institute, Christian-Albrechts-Universität zu Kiel, Kiel, GermanyZoological Institute, Christian-Albrechts-Universität zu Kiel, Kiel, GermanyInstitute of Clinical Molecular Biology, Christian-Albrechts-Universität zu Kiel, Kiel, GermanyInstitute of Clinical Molecular Biology, Christian-Albrechts-Universität zu Kiel, Kiel, GermanyThe eukaryotic host is in close contact to myriads of resident and transient microbes, which influence the crucial physiological pathways. Emerging evidence points to their role of host–microbe interactions for controlling tissue homeostasis, cell fate decisions, and regenerative capacity in epithelial barrier organs including the skin, lung, and gut. In humans and mice, it has been shown that the malignant tumors of these organs harbor an altered microbiota. Mechanistic studies have shown that the altered metabolic properties and secreted factors contribute to epithelial carcinogenesis and tumor progression. Exciting recent work points toward a crucial influence of the associated microbial communities on the response to chemotherapy and immune-check point inhibitors during cancer treatment, which suggests that the modulation of the microbiota might be a powerful tool for personalized oncology. In this article, we provide an overview of how the bacterial signals and signatures may influence epithelial homeostasis across taxa from cnidarians to vertebrates and delineate mechanisms, which might be potential targets for therapy of human diseases by either harnessing barrier integrity (infection and inflammation) or restoring uncontrolled proliferation (cancer).https://www.frontiersin.org/article/10.3389/fmicb.2018.02020/fullmicrobiotaproliferationcancerchemotherapyxenobiotics |
| spellingShingle | Jakob von Frieling Christine Fink Jacob Hamm Kenneth Klischies Michael Forster Thomas C. G. Bosch Thomas Roeder Philip Rosenstiel Felix Sommer Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy Frontiers in Microbiology microbiota proliferation cancer chemotherapy xenobiotics |
| title | Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy |
| title_full | Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy |
| title_fullStr | Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy |
| title_full_unstemmed | Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy |
| title_short | Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy |
| title_sort | grow with the challenge microbial effects on epithelial proliferation carcinogenesis and cancer therapy |
| topic | microbiota proliferation cancer chemotherapy xenobiotics |
| url | https://www.frontiersin.org/article/10.3389/fmicb.2018.02020/full |
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