Rectal Microbiome Composition Correlates with Humoral Immunity to HIV-1 in Vaccinated Rhesus Macaques

Rectal Microbiome Composition Correlates with Humoral Immunity to HIV-1 in Vaccinated Rhesus Macaques

ABSTRACT The microbiome is an integral and dynamic component of the host and is emerging as a critical determinant of immune responses; however, its influence on vaccine immunogenicity is largely not well understood. Here, we examined the pivotal relationship between the mucosal microbiome and vacci...

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Bibliographic Details
Main Authors: Sonny R. Elizaldi, Anil Verma, Korey A. Walter, Matthew Rolston, Ashok R. Dinasarapu, Blythe P. Durbin-Johnson, Matthew Settles, Pamela A. Kozlowski, Reben Raeman, Smita S. Iyer
Format: Article
Language:English
Published: American Society for Microbiology 2019-12-01
Series:mSphere
Subjects:
vaccine
DNA
HIV-1
antibody response
microbiome
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00824-19

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