Microbial dysbiosis and fecal metabolomic perturbations in Yorkshire Terriers with chronic enteropathy
Abstract Dysbiosis and perturbations of fecal metabolic profiles have been reported in dogs with inflammatory bowel disease. Currently the incidence of dysbiosis and the fecal metabolomic profile in Yorkshire Terriers with chronic enteropathy (YTE) and the effects of treatment are unknown. This pros...
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| Format: | Article |
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Nature Portfolio
2022-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-17244-6 |
| _version_ | 1818018590279860224 |
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| author | Alexandra I. Galler Jan S. Suchodolski Joerg M. Steiner Chi-Hsuan Sung Katharina M. Hittmair Barbara Richter Iwan A. Burgener |
| author_facet | Alexandra I. Galler Jan S. Suchodolski Joerg M. Steiner Chi-Hsuan Sung Katharina M. Hittmair Barbara Richter Iwan A. Burgener |
| author_sort | Alexandra I. Galler |
| collection | DOAJ |
| description | Abstract Dysbiosis and perturbations of fecal metabolic profiles have been reported in dogs with inflammatory bowel disease. Currently the incidence of dysbiosis and the fecal metabolomic profile in Yorkshire Terriers with chronic enteropathy (YTE) and the effects of treatment are unknown. This prospective observational study analyzed the dysbiosis index (DI) and fecal bile acid, sterol and fatty acid profiles in 14 Yorkshire Terriers with active YTE, 11 dogs in clinical remission, and 26 healthy Yorkshire Terriers. YTE was associated with dysbiosis and a significant increase in fatty acids (docosanoate, p = 0.002; gondoate, p = 0.026; erucate, p < 0.001; nervonate, p < 0.001; linolenate, p < 0.001), and plant sterols (campesterol, p < 0.001; brassicasterol, p = 0.024). The abundances of Fusobacterium (p < 0.001) and Cl. hiranonis (p = 0.018) and the concentrations of the secondary bile acid ursodeoxycholic acid (p = 0.033) and the plant sterol sitostanol (p = 0.003) were significantly decreased compared to healthy dogs. Dysbiosis, abundances of Fusobacterium, Cl. hiranonis and fecal concentrations of bile acids and sterols did not recover after treatment, while fecal fatty acid concentrations decreased in treated dogs. YTE is associated with dysbiosis and changes in bile acid, fatty acid, and sterol metabolism. These changes only recovered partially despite clinical remission. They might be breed-specific and involved in the pathogenesis of YTE. |
| first_indexed | 2024-04-14T07:41:40Z |
| format | Article |
| id | doaj.art-b78c7529d1f14664bf7a0fea3f7eab15 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-14T07:41:40Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b78c7529d1f14664bf7a0fea3f7eab152022-12-22T02:05:29ZengNature PortfolioScientific Reports2045-23222022-07-0112111710.1038/s41598-022-17244-6Microbial dysbiosis and fecal metabolomic perturbations in Yorkshire Terriers with chronic enteropathyAlexandra I. Galler0Jan S. Suchodolski1Joerg M. Steiner2Chi-Hsuan Sung3Katharina M. Hittmair4Barbara Richter5Iwan A. Burgener6Small Animal Internal Medicine, University of Veterinary MedicineGastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&M UniversityGastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&M UniversityGastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&M UniversityClinical Unit of Diagnostic Imaging, University of Veterinary MedicineInstitute of Pathology, University of Veterinary MedicineSmall Animal Internal Medicine, University of Veterinary MedicineAbstract Dysbiosis and perturbations of fecal metabolic profiles have been reported in dogs with inflammatory bowel disease. Currently the incidence of dysbiosis and the fecal metabolomic profile in Yorkshire Terriers with chronic enteropathy (YTE) and the effects of treatment are unknown. This prospective observational study analyzed the dysbiosis index (DI) and fecal bile acid, sterol and fatty acid profiles in 14 Yorkshire Terriers with active YTE, 11 dogs in clinical remission, and 26 healthy Yorkshire Terriers. YTE was associated with dysbiosis and a significant increase in fatty acids (docosanoate, p = 0.002; gondoate, p = 0.026; erucate, p < 0.001; nervonate, p < 0.001; linolenate, p < 0.001), and plant sterols (campesterol, p < 0.001; brassicasterol, p = 0.024). The abundances of Fusobacterium (p < 0.001) and Cl. hiranonis (p = 0.018) and the concentrations of the secondary bile acid ursodeoxycholic acid (p = 0.033) and the plant sterol sitostanol (p = 0.003) were significantly decreased compared to healthy dogs. Dysbiosis, abundances of Fusobacterium, Cl. hiranonis and fecal concentrations of bile acids and sterols did not recover after treatment, while fecal fatty acid concentrations decreased in treated dogs. YTE is associated with dysbiosis and changes in bile acid, fatty acid, and sterol metabolism. These changes only recovered partially despite clinical remission. They might be breed-specific and involved in the pathogenesis of YTE.https://doi.org/10.1038/s41598-022-17244-6 |
| spellingShingle | Alexandra I. Galler Jan S. Suchodolski Joerg M. Steiner Chi-Hsuan Sung Katharina M. Hittmair Barbara Richter Iwan A. Burgener Microbial dysbiosis and fecal metabolomic perturbations in Yorkshire Terriers with chronic enteropathy Scientific Reports |
| title | Microbial dysbiosis and fecal metabolomic perturbations in Yorkshire Terriers with chronic enteropathy |
| title_full | Microbial dysbiosis and fecal metabolomic perturbations in Yorkshire Terriers with chronic enteropathy |
| title_fullStr | Microbial dysbiosis and fecal metabolomic perturbations in Yorkshire Terriers with chronic enteropathy |
| title_full_unstemmed | Microbial dysbiosis and fecal metabolomic perturbations in Yorkshire Terriers with chronic enteropathy |
| title_short | Microbial dysbiosis and fecal metabolomic perturbations in Yorkshire Terriers with chronic enteropathy |
| title_sort | microbial dysbiosis and fecal metabolomic perturbations in yorkshire terriers with chronic enteropathy |
| url | https://doi.org/10.1038/s41598-022-17244-6 |
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