Spontaneous regression of secondary vitreoretinal lymphoma after diagnostic vitrectomy: case report
Abstract Purpose Our purpose is to report a patient with secondary intraocular mucosa-associated lymphoid tissue (MALT) who experienced spontaneous regression after diagnostic vitrectomy. Methods We retrospectively reviewed the clinical and imaging features of the case. Multimodal imaging, including...
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12886-023-02967-5 |
| _version_ | 1797822966125297664 |
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| author | Linyang Gan Junjie Ye |
| author_facet | Linyang Gan Junjie Ye |
| author_sort | Linyang Gan |
| collection | DOAJ |
| description | Abstract Purpose Our purpose is to report a patient with secondary intraocular mucosa-associated lymphoid tissue (MALT) who experienced spontaneous regression after diagnostic vitrectomy. Methods We retrospectively reviewed the clinical and imaging features of the case. Multimodal imaging, including fundus photograph, optical coherence tomography, fundus fluorescein angiography and ultrasound scan was presented. Results A 71-year-old female presented with a subretinal lesion temporal to macula and scattered multifocal creamy lesions deep to retina in her left eye. Optical coherence tomography of the left eye showed multifocal nodular hyper-reflective signals between the Bruch’s membrane and RPE. She had a history of gastric MALT lymphoma. Diagnostic vitrectomy was performed. IL-10 level of aqueous was 187.7pg/ml. Cytology, gene rearrangement and flow cytometry of the vitreous were inconclusive. Systemic evaluation was normal. Secondary vitreoretinal MALT lymphoma was considered. Interestingly, her subretinal lesions regressed gradually without any chemotherapy. And IL-10 level of aqueous declined to 64.3pg/ml. Conclusions Secondary vitreoretinal MALT lymphoma is extremely rare. Spontaneous regression of intraocular lymphoma does occur. |
| first_indexed | 2024-03-13T10:17:03Z |
| format | Article |
| id | doaj.art-b78d086825344845a2f9d7ceda73cb74 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-03-13T10:17:03Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-b78d086825344845a2f9d7ceda73cb742023-05-21T11:11:37ZengBMCBMC Ophthalmology1471-24152023-05-012311410.1186/s12886-023-02967-5Spontaneous regression of secondary vitreoretinal lymphoma after diagnostic vitrectomy: case reportLinyang Gan0Junjie Ye1Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesDepartment of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesAbstract Purpose Our purpose is to report a patient with secondary intraocular mucosa-associated lymphoid tissue (MALT) who experienced spontaneous regression after diagnostic vitrectomy. Methods We retrospectively reviewed the clinical and imaging features of the case. Multimodal imaging, including fundus photograph, optical coherence tomography, fundus fluorescein angiography and ultrasound scan was presented. Results A 71-year-old female presented with a subretinal lesion temporal to macula and scattered multifocal creamy lesions deep to retina in her left eye. Optical coherence tomography of the left eye showed multifocal nodular hyper-reflective signals between the Bruch’s membrane and RPE. She had a history of gastric MALT lymphoma. Diagnostic vitrectomy was performed. IL-10 level of aqueous was 187.7pg/ml. Cytology, gene rearrangement and flow cytometry of the vitreous were inconclusive. Systemic evaluation was normal. Secondary vitreoretinal MALT lymphoma was considered. Interestingly, her subretinal lesions regressed gradually without any chemotherapy. And IL-10 level of aqueous declined to 64.3pg/ml. Conclusions Secondary vitreoretinal MALT lymphoma is extremely rare. Spontaneous regression of intraocular lymphoma does occur.https://doi.org/10.1186/s12886-023-02967-5Secondary vitreoretinal lymphomaDiagnostic vitrectomySpontaneous regressionGastric MALT lymphomaCase report |
| spellingShingle | Linyang Gan Junjie Ye Spontaneous regression of secondary vitreoretinal lymphoma after diagnostic vitrectomy: case report BMC Ophthalmology Secondary vitreoretinal lymphoma Diagnostic vitrectomy Spontaneous regression Gastric MALT lymphoma Case report |
| title | Spontaneous regression of secondary vitreoretinal lymphoma after diagnostic vitrectomy: case report |
| title_full | Spontaneous regression of secondary vitreoretinal lymphoma after diagnostic vitrectomy: case report |
| title_fullStr | Spontaneous regression of secondary vitreoretinal lymphoma after diagnostic vitrectomy: case report |
| title_full_unstemmed | Spontaneous regression of secondary vitreoretinal lymphoma after diagnostic vitrectomy: case report |
| title_short | Spontaneous regression of secondary vitreoretinal lymphoma after diagnostic vitrectomy: case report |
| title_sort | spontaneous regression of secondary vitreoretinal lymphoma after diagnostic vitrectomy case report |
| topic | Secondary vitreoretinal lymphoma Diagnostic vitrectomy Spontaneous regression Gastric MALT lymphoma Case report |
| url | https://doi.org/10.1186/s12886-023-02967-5 |
| work_keys_str_mv | AT linyanggan spontaneousregressionofsecondaryvitreoretinallymphomaafterdiagnosticvitrectomycasereport AT junjieye spontaneousregressionofsecondaryvitreoretinallymphomaafterdiagnosticvitrectomycasereport |