Effects of Lipopolysaccharide-Binding Protein (LBP) Single Nucleotide Polymorphism (SNP) in Infections, Inflammatory Diseases, Metabolic Disorders and Cancers
Inflammation, which is induced by the immune response, is recognized as the driving factor in many diseases, including infections and inflammatory diseases, metabolic disorders and cancers. Genetic variations in pivotal genes associated with the immune response, particularly single nucleotide polymo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.681810/full |
| _version_ | 1818907333956206592 |
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| author | Leilei Meng Zichen Song Anding Liu Uta Dahmen Xiao Yang Haoshu Fang |
| author_facet | Leilei Meng Zichen Song Anding Liu Uta Dahmen Xiao Yang Haoshu Fang |
| author_sort | Leilei Meng |
| collection | DOAJ |
| description | Inflammation, which is induced by the immune response, is recognized as the driving factor in many diseases, including infections and inflammatory diseases, metabolic disorders and cancers. Genetic variations in pivotal genes associated with the immune response, particularly single nucleotide polymorphisms (SNPs), may account for predisposition and clinical outcome of diseases. Lipopolysaccharide (LPS)-binding protein (LBP) functions as an enhancer of the host response to LPS, the main component of the outer membrane of gram-native bacteria. Given the crucial role of LBP in inflammation, we will review the impact of SNPs in the LBP gene on infections and inflammatory diseases, metabolic disorders and cancers. |
| first_indexed | 2024-12-19T21:53:28Z |
| format | Article |
| id | doaj.art-b78d5e802e274e79a3bd4d7b1618ee6a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-19T21:53:28Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b78d5e802e274e79a3bd4d7b1618ee6a2022-12-21T20:04:20ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-07-011210.3389/fimmu.2021.681810681810Effects of Lipopolysaccharide-Binding Protein (LBP) Single Nucleotide Polymorphism (SNP) in Infections, Inflammatory Diseases, Metabolic Disorders and CancersLeilei Meng0Zichen Song1Anding Liu2Uta Dahmen3Xiao Yang4Haoshu Fang5Department of Pathophysiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, ChinaDepartment of Pathophysiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, ChinaExperimental Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaExperimental Transplantation Surgery, Department of General, Visceral and Vascular Surgery, Friedrich-Schiller-University Jena, Jena, GermanyExperimental Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Pathophysiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, ChinaInflammation, which is induced by the immune response, is recognized as the driving factor in many diseases, including infections and inflammatory diseases, metabolic disorders and cancers. Genetic variations in pivotal genes associated with the immune response, particularly single nucleotide polymorphisms (SNPs), may account for predisposition and clinical outcome of diseases. Lipopolysaccharide (LPS)-binding protein (LBP) functions as an enhancer of the host response to LPS, the main component of the outer membrane of gram-native bacteria. Given the crucial role of LBP in inflammation, we will review the impact of SNPs in the LBP gene on infections and inflammatory diseases, metabolic disorders and cancers.https://www.frontiersin.org/articles/10.3389/fimmu.2021.681810/fullinflammationsingle nucleotide polymorphismslipopolysaccharide-binding proteininfectionsinflammatory diseasesmetabolic disorders |
| spellingShingle | Leilei Meng Zichen Song Anding Liu Uta Dahmen Xiao Yang Haoshu Fang Effects of Lipopolysaccharide-Binding Protein (LBP) Single Nucleotide Polymorphism (SNP) in Infections, Inflammatory Diseases, Metabolic Disorders and Cancers Frontiers in Immunology inflammation single nucleotide polymorphisms lipopolysaccharide-binding protein infections inflammatory diseases metabolic disorders |
| title | Effects of Lipopolysaccharide-Binding Protein (LBP) Single Nucleotide Polymorphism (SNP) in Infections, Inflammatory Diseases, Metabolic Disorders and Cancers |
| title_full | Effects of Lipopolysaccharide-Binding Protein (LBP) Single Nucleotide Polymorphism (SNP) in Infections, Inflammatory Diseases, Metabolic Disorders and Cancers |
| title_fullStr | Effects of Lipopolysaccharide-Binding Protein (LBP) Single Nucleotide Polymorphism (SNP) in Infections, Inflammatory Diseases, Metabolic Disorders and Cancers |
| title_full_unstemmed | Effects of Lipopolysaccharide-Binding Protein (LBP) Single Nucleotide Polymorphism (SNP) in Infections, Inflammatory Diseases, Metabolic Disorders and Cancers |
| title_short | Effects of Lipopolysaccharide-Binding Protein (LBP) Single Nucleotide Polymorphism (SNP) in Infections, Inflammatory Diseases, Metabolic Disorders and Cancers |
| title_sort | effects of lipopolysaccharide binding protein lbp single nucleotide polymorphism snp in infections inflammatory diseases metabolic disorders and cancers |
| topic | inflammation single nucleotide polymorphisms lipopolysaccharide-binding protein infections inflammatory diseases metabolic disorders |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.681810/full |
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