The journey from viral hepatitis to hypocythemia: two case reports
Acute viral hepatitis, including hepatitis A, B, E, D, and G, can lead to severe bone marrow suppression due to cytotoxic lymphocytes. The bone marrow suppression causes aplastic anaemia which is mostly unresponsive to immunosuppressive therapy. Such patients require bone marrow transplant for a co...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Pakistan Medical Association
2023-02-01
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| Series: | Journal of the Pakistan Medical Association |
| Online Access: | https://www.ojs.jpma.org.pk/index.php/public_html/article/view/6198 |
| _version_ | 1797820960596819968 |
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| author | Hassan Ur Rehman Ayesha Javed Nabeel Tariq Nida Zeb Abbasi |
| author_facet | Hassan Ur Rehman Ayesha Javed Nabeel Tariq Nida Zeb Abbasi |
| author_sort | Hassan Ur Rehman |
| collection | DOAJ |
| description |
Acute viral hepatitis, including hepatitis A, B, E, D, and G, can lead to severe bone marrow suppression due to cytotoxic lymphocytes. The bone marrow suppression causes aplastic anaemia which is mostly unresponsive to immunosuppressive therapy. Such patients require bone marrow transplant for a complete cure. The pancytopenia can evolve during recovery from transaminitis. We are presenting two case reports relating aplastic anaemia with acute viral hepatitis in two young patients—23 and 16 years of age. The 23-year-old female patient had hepatitis A associated with aplastic anaemia whereas the young 16-year-old male patient was diagnosed with Hepatitis E IgG associated aplastic anaemia. Unfortunately, the first patient could not cope with the complications relating to pancytopenia and was unable to reach the bone marrow transplant stage. The second patient did not have a bone marrow transplant but showed an excellent response to immunosuppressive therapy before the transplant and survived.
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| first_indexed | 2024-03-13T09:45:49Z |
| format | Article |
| id | doaj.art-b78dd6bb9660423f80161bf345d99ab0 |
| institution | Directory Open Access Journal |
| issn | 0030-9982 |
| language | English |
| last_indexed | 2024-03-13T09:45:49Z |
| publishDate | 2023-02-01 |
| publisher | Pakistan Medical Association |
| record_format | Article |
| series | Journal of the Pakistan Medical Association |
| spelling | doaj.art-b78dd6bb9660423f80161bf345d99ab02023-05-25T04:20:39ZengPakistan Medical AssociationJournal of the Pakistan Medical Association0030-99822023-02-0173210.47391/JPMA.6198020The journey from viral hepatitis to hypocythemia: two case reportsHassan Ur Rehman0Ayesha Javed1Nabeel Tariq2Nida Zeb Abbasi3Department of Internal Medicine and Endocrinology, Pakistan Institute of Medical Sciences / Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, PakistanDepartment of Internal Medicine and Endocrinology, Pakistan Institute of Medical Sciences / Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, PakistanDepartment of Internal Medicine and Endocrinology, Pakistan Institute of Medical Sciences / Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, PakistanDepartment of Internal Medicine and Endocrinology, Pakistan Institute of Medical Sciences / Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan Acute viral hepatitis, including hepatitis A, B, E, D, and G, can lead to severe bone marrow suppression due to cytotoxic lymphocytes. The bone marrow suppression causes aplastic anaemia which is mostly unresponsive to immunosuppressive therapy. Such patients require bone marrow transplant for a complete cure. The pancytopenia can evolve during recovery from transaminitis. We are presenting two case reports relating aplastic anaemia with acute viral hepatitis in two young patients—23 and 16 years of age. The 23-year-old female patient had hepatitis A associated with aplastic anaemia whereas the young 16-year-old male patient was diagnosed with Hepatitis E IgG associated aplastic anaemia. Unfortunately, the first patient could not cope with the complications relating to pancytopenia and was unable to reach the bone marrow transplant stage. The second patient did not have a bone marrow transplant but showed an excellent response to immunosuppressive therapy before the transplant and survived. https://www.ojs.jpma.org.pk/index.php/public_html/article/view/6198 |
| spellingShingle | Hassan Ur Rehman Ayesha Javed Nabeel Tariq Nida Zeb Abbasi The journey from viral hepatitis to hypocythemia: two case reports Journal of the Pakistan Medical Association |
| title | The journey from viral hepatitis to hypocythemia: two case reports |
| title_full | The journey from viral hepatitis to hypocythemia: two case reports |
| title_fullStr | The journey from viral hepatitis to hypocythemia: two case reports |
| title_full_unstemmed | The journey from viral hepatitis to hypocythemia: two case reports |
| title_short | The journey from viral hepatitis to hypocythemia: two case reports |
| title_sort | journey from viral hepatitis to hypocythemia two case reports |
| url | https://www.ojs.jpma.org.pk/index.php/public_html/article/view/6198 |
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