Intra-articular delivery of AAV vectors encoding PD-L1 attenuates joint inflammation and tissue damage in a mouse model of rheumatoid arthritis

Intra-articular delivery of AAV vectors encoding PD-L1 attenuates joint inflammation and tissue damage in a mouse model of rheumatoid arthritis

ObjectiveRheumatoid arthritis (RA) is the most common form of autoimmune inflammatory arthritis. Intra-articular gene delivery to block proinflammatory cytokines has been studied in pre-clinical models and human clinical trials. It has been demonstrated that the level of programmed death-ligand 1 (P...

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Bibliographic Details
Main Authors: Wenjun Li, Junjiang Sun, Susi Liu Feng, Feng Wang, Michael Z. Miao, Eveline Y. Wu, Shannon Wallet, Richard Loeser, Chengwen Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
PD-L1
rheu matoid arthritis
AAV (Adeno-associated virus)
Inflammation
Gene Therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1116084/full

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