Mechanobiologically optimized Ti–35Nb–2Ta–3Zr improves load transduction and enhances bone remodeling in tilted dental implant therapy
The tilted implant with immediate function is increasingly used in clinical dental therapy for edentulous and partially edentulous patients with excessive bone resorption and the anatomic limitations in the alveolar ridge. However, peri-implant cervical bone loss can be caused by the stress shieldin...
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| Format: | Article |
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KeAi Communications Co., Ltd.
2022-10-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X22001207 |
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| author | Chuanyuan Mao Weijun Yu Min Jin Yingchen Wang Xiaoqing Shang Lu Lin Xiaoqin Zeng Liqiang Wang Eryi Lu |
| author_facet | Chuanyuan Mao Weijun Yu Min Jin Yingchen Wang Xiaoqing Shang Lu Lin Xiaoqin Zeng Liqiang Wang Eryi Lu |
| author_sort | Chuanyuan Mao |
| collection | DOAJ |
| description | The tilted implant with immediate function is increasingly used in clinical dental therapy for edentulous and partially edentulous patients with excessive bone resorption and the anatomic limitations in the alveolar ridge. However, peri-implant cervical bone loss can be caused by the stress shielding effect. Herein, inspired by the concept of “materiobiology”, the mechanical characteristics of materials were considered along with bone biology for tilted implant design. In this study, a novel Ti–35Nb–2Ta–3Zr alloy (TNTZ) implant with low elastic modulus, high strength and favorable biocompatibility was developed. Then the human alveolar bone environment was mimicked in goat and finite element (FE) models to investigate the mechanical property and the related peri-implant bone remodeling of TNTZ compared to commonly used Ti–6Al–4V (TC4) in tilted implantation under loading condition. Next, a layer-by-layer quantitative correlation of the FE and X-ray Microscopy (XRM) analysis suggested that the TNTZ implant present better mechanobiological characteristics including improved load transduction and increased bone area in the tilted implantation model compared to TC4 implant, especially in the upper 1/3 region of peri-implant bone that is “lower stress”. Finally, combining the static and dynamic parameters of bone, it was further verified that TNTZ enhanced bone remodeling in “lower stress” upper 1/3 region. This study demonstrates that TNTZ is a mechanobiological optimized tilted implant material that enhances load transduction and bone remodeling. |
| first_indexed | 2024-04-24T08:21:48Z |
| format | Article |
| id | doaj.art-b79159b32e004de6a0e6c972caa4bffd |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:21:48Z |
| publishDate | 2022-10-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-b79159b32e004de6a0e6c972caa4bffd2024-04-17T00:44:13ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2022-10-01161526Mechanobiologically optimized Ti–35Nb–2Ta–3Zr improves load transduction and enhances bone remodeling in tilted dental implant therapyChuanyuan Mao0Weijun Yu1Min Jin2Yingchen Wang3Xiaoqing Shang4Lu Lin5Xiaoqin Zeng6Liqiang Wang7Eryi Lu8Department of Stomatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, ChinaDepartment of Stomatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, ChinaDepartment of Stomatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, ChinaState Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Materials Genome Initiative Centre, Shanghai Jiao Tong University, Shanghai, 200240, ChinaNational Engineering Research Center of Light Alloy Net Forming, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, ChinaDepartment of Stomatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, ChinaNational Engineering Research Center of Light Alloy Net Forming, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China; Corresponding author.State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Materials Genome Initiative Centre, Shanghai Jiao Tong University, Shanghai, 200240, China; Corresponding author.Department of Stomatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China; Corresponding author.The tilted implant with immediate function is increasingly used in clinical dental therapy for edentulous and partially edentulous patients with excessive bone resorption and the anatomic limitations in the alveolar ridge. However, peri-implant cervical bone loss can be caused by the stress shielding effect. Herein, inspired by the concept of “materiobiology”, the mechanical characteristics of materials were considered along with bone biology for tilted implant design. In this study, a novel Ti–35Nb–2Ta–3Zr alloy (TNTZ) implant with low elastic modulus, high strength and favorable biocompatibility was developed. Then the human alveolar bone environment was mimicked in goat and finite element (FE) models to investigate the mechanical property and the related peri-implant bone remodeling of TNTZ compared to commonly used Ti–6Al–4V (TC4) in tilted implantation under loading condition. Next, a layer-by-layer quantitative correlation of the FE and X-ray Microscopy (XRM) analysis suggested that the TNTZ implant present better mechanobiological characteristics including improved load transduction and increased bone area in the tilted implantation model compared to TC4 implant, especially in the upper 1/3 region of peri-implant bone that is “lower stress”. Finally, combining the static and dynamic parameters of bone, it was further verified that TNTZ enhanced bone remodeling in “lower stress” upper 1/3 region. This study demonstrates that TNTZ is a mechanobiological optimized tilted implant material that enhances load transduction and bone remodeling.http://www.sciencedirect.com/science/article/pii/S2452199X22001207Ti-35Nb–2Ta–3ZrTilted implantLow elastic modulusBone remodelingMechanobiologically optimization |
| spellingShingle | Chuanyuan Mao Weijun Yu Min Jin Yingchen Wang Xiaoqing Shang Lu Lin Xiaoqin Zeng Liqiang Wang Eryi Lu Mechanobiologically optimized Ti–35Nb–2Ta–3Zr improves load transduction and enhances bone remodeling in tilted dental implant therapy Bioactive Materials Ti-35Nb–2Ta–3Zr Tilted implant Low elastic modulus Bone remodeling Mechanobiologically optimization |
| title | Mechanobiologically optimized Ti–35Nb–2Ta–3Zr improves load transduction and enhances bone remodeling in tilted dental implant therapy |
| title_full | Mechanobiologically optimized Ti–35Nb–2Ta–3Zr improves load transduction and enhances bone remodeling in tilted dental implant therapy |
| title_fullStr | Mechanobiologically optimized Ti–35Nb–2Ta–3Zr improves load transduction and enhances bone remodeling in tilted dental implant therapy |
| title_full_unstemmed | Mechanobiologically optimized Ti–35Nb–2Ta–3Zr improves load transduction and enhances bone remodeling in tilted dental implant therapy |
| title_short | Mechanobiologically optimized Ti–35Nb–2Ta–3Zr improves load transduction and enhances bone remodeling in tilted dental implant therapy |
| title_sort | mechanobiologically optimized ti 35nb 2ta 3zr improves load transduction and enhances bone remodeling in tilted dental implant therapy |
| topic | Ti-35Nb–2Ta–3Zr Tilted implant Low elastic modulus Bone remodeling Mechanobiologically optimization |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X22001207 |
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