Modified Myocardial Performance Index in Fetal Growth Disturbances as Diagnostic and Prognostic Adjunct
Background: Fetal growth disturbance can be associated with cardiac dysfunction. This study aimed to assess the modified myocardial performance index in growth-restricted and appropriate for gestational age fetuses and evaluate both its prognostic value in perinatal period and also its association w...
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| Format: | Article |
| Language: | English |
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KARE Publishing
2023-01-01
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| Series: | Anatolian Journal of Cardiology |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-05332 |
| _version_ | 1797643222566043648 |
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| author | Ayşe Şimşek Semir Köse |
| author_facet | Ayşe Şimşek Semir Köse |
| author_sort | Ayşe Şimşek |
| collection | DOAJ |
| description | Background: Fetal growth disturbance can be associated with cardiac dysfunction. This study aimed to assess the modified myocardial performance index in growth-restricted and appropriate for gestational age fetuses and evaluate both its prognostic value in perinatal period and also its association with adverse perinatal outcomes.
Methods: Totally 131 pregnant women were included in this prospective study. Of these, 56 cases were in study group with a diagnosis of small fetus and 75 cases were in control group with a diagnosis appropriately grown fetus. Fetal echocardiography was performed in all pregnant women to measure modified myocardial performance index. Umbilical, middle cerebral and uterine artery Doppler ultrasound parameters were measured in the study group. Small fetuses were categorized into 2 subgroups of late-onset fetal growth restriction and small for gestational age.
Results: Modified myocardial performance index was significantly higher in small fetuses compared to controls (0.45 vs. 0.37, P <.001). Newborn intensive care unit admission rates were significantly higher in small fetuses than in controls (chi-square test, P <.001). The
highest mean modified myocardial performance index was recorded in the late-onset fetal growth restriction subgroup (0.45 vs. 0.41 vs. 0.37). The sensitivity and specificity of modified myocardial performance index in predicting adverse outcomes at a cut-off value of 0.41 were 63% and 75%, respectively. There was a significant negative correlation between modified myocardial performance index values and birth weights.
Conclusions: We found higher left fetal heart modified myocardial performance index values in small fetuses indicating the presence of prenatal cardiac dysfunction. Fetal myocardial performance deteriorates in concordance with severity of growth restriction. Modified myocardial performance index can also be used to predict adverse perinatal outcomes among growth-restricted fetuses. |
| first_indexed | 2024-03-11T14:12:31Z |
| format | Article |
| id | doaj.art-b7921760e7634a09a8ae61ae78369522 |
| institution | Directory Open Access Journal |
| issn | 2149-2271 |
| language | English |
| last_indexed | 2024-03-11T14:12:31Z |
| publishDate | 2023-01-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Anatolian Journal of Cardiology |
| spelling | doaj.art-b7921760e7634a09a8ae61ae783695222023-11-01T19:16:53ZengKARE PublishingAnatolian Journal of Cardiology2149-22712023-01-01271344010.14744/AnatolJCardiol.2022.2577AJC-05332Modified Myocardial Performance Index in Fetal Growth Disturbances as Diagnostic and Prognostic AdjunctAyşe Şimşek0Semir Köse1Department of Pediatric Cardiology, Democracy University Faculty of Medicine, Buca Seyfi Demirsoy Training and Research Hospital, İzmir, TürkiyeDepartment of Perinatology, Buca Seyfi Demirsoy Training and Research Hospital, İzmir, TürkiyeBackground: Fetal growth disturbance can be associated with cardiac dysfunction. This study aimed to assess the modified myocardial performance index in growth-restricted and appropriate for gestational age fetuses and evaluate both its prognostic value in perinatal period and also its association with adverse perinatal outcomes. Methods: Totally 131 pregnant women were included in this prospective study. Of these, 56 cases were in study group with a diagnosis of small fetus and 75 cases were in control group with a diagnosis appropriately grown fetus. Fetal echocardiography was performed in all pregnant women to measure modified myocardial performance index. Umbilical, middle cerebral and uterine artery Doppler ultrasound parameters were measured in the study group. Small fetuses were categorized into 2 subgroups of late-onset fetal growth restriction and small for gestational age. Results: Modified myocardial performance index was significantly higher in small fetuses compared to controls (0.45 vs. 0.37, P <.001). Newborn intensive care unit admission rates were significantly higher in small fetuses than in controls (chi-square test, P <.001). The highest mean modified myocardial performance index was recorded in the late-onset fetal growth restriction subgroup (0.45 vs. 0.41 vs. 0.37). The sensitivity and specificity of modified myocardial performance index in predicting adverse outcomes at a cut-off value of 0.41 were 63% and 75%, respectively. There was a significant negative correlation between modified myocardial performance index values and birth weights. Conclusions: We found higher left fetal heart modified myocardial performance index values in small fetuses indicating the presence of prenatal cardiac dysfunction. Fetal myocardial performance deteriorates in concordance with severity of growth restriction. Modified myocardial performance index can also be used to predict adverse perinatal outcomes among growth-restricted fetuses.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-05332cardiac functionlate-onset fetal growth restrictionmodified myocardial performance indexsmall for gestational age |
| spellingShingle | Ayşe Şimşek Semir Köse Modified Myocardial Performance Index in Fetal Growth Disturbances as Diagnostic and Prognostic Adjunct Anatolian Journal of Cardiology cardiac function late-onset fetal growth restriction modified myocardial performance index small for gestational age |
| title | Modified Myocardial Performance Index in Fetal Growth Disturbances as Diagnostic and Prognostic Adjunct |
| title_full | Modified Myocardial Performance Index in Fetal Growth Disturbances as Diagnostic and Prognostic Adjunct |
| title_fullStr | Modified Myocardial Performance Index in Fetal Growth Disturbances as Diagnostic and Prognostic Adjunct |
| title_full_unstemmed | Modified Myocardial Performance Index in Fetal Growth Disturbances as Diagnostic and Prognostic Adjunct |
| title_short | Modified Myocardial Performance Index in Fetal Growth Disturbances as Diagnostic and Prognostic Adjunct |
| title_sort | modified myocardial performance index in fetal growth disturbances as diagnostic and prognostic adjunct |
| topic | cardiac function late-onset fetal growth restriction modified myocardial performance index small for gestational age |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-05332 |
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