Epigenetic impacts of maternal tobacco and e-vapour exposure on the offspring lung
Abstract In utero exposure to tobacco products, whether maternal or environmental, have harmful effects on first neonatal and later adult respiratory outcomes. These effects have been shown to persist across subsequent generations, regardless of the offsprings’ smoking habits. Established epigenetic...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-02-01
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| Series: | Clinical Epigenetics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13148-019-0631-3 |
| _version_ | 1828356476477898752 |
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| author | Razia Zakarya Ian Adcock Brian G. Oliver |
| author_facet | Razia Zakarya Ian Adcock Brian G. Oliver |
| author_sort | Razia Zakarya |
| collection | DOAJ |
| description | Abstract In utero exposure to tobacco products, whether maternal or environmental, have harmful effects on first neonatal and later adult respiratory outcomes. These effects have been shown to persist across subsequent generations, regardless of the offsprings’ smoking habits. Established epigenetic modifications induced by in utero exposure are postulated as the mechanism underlying the inherited poor respiratory outcomes. As e-cigarette use is on the rise, their potential to induce similar functional respiratory deficits underpinned by an alteration in the foetal epigenome needs to be explored. This review will focus on the functional and epigenetic impact of in utero exposure to maternal cigarette smoke, maternal environmental tobacco smoke, environmental tobacco smoke and e-cigarette vapour on foetal respiratory outcomes. |
| first_indexed | 2024-04-14T02:59:34Z |
| format | Article |
| id | doaj.art-b792b3f1f491413e9aebddf99a787f9c |
| institution | Directory Open Access Journal |
| issn | 1868-7075 1868-7083 |
| language | English |
| last_indexed | 2024-04-14T02:59:34Z |
| publishDate | 2019-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Clinical Epigenetics |
| spelling | doaj.art-b792b3f1f491413e9aebddf99a787f9c2022-12-22T02:15:57ZengBMCClinical Epigenetics1868-70751868-70832019-02-0111111110.1186/s13148-019-0631-3Epigenetic impacts of maternal tobacco and e-vapour exposure on the offspring lungRazia Zakarya0Ian Adcock1Brian G. Oliver2Respiratory Cellular and Molecular Biology, Woolcock Institute of Medical Research, The University of SydneyAirway Diseases Section, National Heart and Lung Institute, Imperial College LondonRespiratory Cellular and Molecular Biology, Woolcock Institute of Medical Research, The University of SydneyAbstract In utero exposure to tobacco products, whether maternal or environmental, have harmful effects on first neonatal and later adult respiratory outcomes. These effects have been shown to persist across subsequent generations, regardless of the offsprings’ smoking habits. Established epigenetic modifications induced by in utero exposure are postulated as the mechanism underlying the inherited poor respiratory outcomes. As e-cigarette use is on the rise, their potential to induce similar functional respiratory deficits underpinned by an alteration in the foetal epigenome needs to be explored. This review will focus on the functional and epigenetic impact of in utero exposure to maternal cigarette smoke, maternal environmental tobacco smoke, environmental tobacco smoke and e-cigarette vapour on foetal respiratory outcomes.http://link.springer.com/article/10.1186/s13148-019-0631-3EpigeneticsAirwayLung developmentAsthmaCOPDE-cigarette |
| spellingShingle | Razia Zakarya Ian Adcock Brian G. Oliver Epigenetic impacts of maternal tobacco and e-vapour exposure on the offspring lung Clinical Epigenetics Epigenetics Airway Lung development Asthma COPD E-cigarette |
| title | Epigenetic impacts of maternal tobacco and e-vapour exposure on the offspring lung |
| title_full | Epigenetic impacts of maternal tobacco and e-vapour exposure on the offspring lung |
| title_fullStr | Epigenetic impacts of maternal tobacco and e-vapour exposure on the offspring lung |
| title_full_unstemmed | Epigenetic impacts of maternal tobacco and e-vapour exposure on the offspring lung |
| title_short | Epigenetic impacts of maternal tobacco and e-vapour exposure on the offspring lung |
| title_sort | epigenetic impacts of maternal tobacco and e vapour exposure on the offspring lung |
| topic | Epigenetics Airway Lung development Asthma COPD E-cigarette |
| url | http://link.springer.com/article/10.1186/s13148-019-0631-3 |
| work_keys_str_mv | AT raziazakarya epigeneticimpactsofmaternaltobaccoandevapourexposureontheoffspringlung AT ianadcock epigeneticimpactsofmaternaltobaccoandevapourexposureontheoffspringlung AT briangoliver epigeneticimpactsofmaternaltobaccoandevapourexposureontheoffspringlung |