A STUDY OF EFFICACY OF TREATMENT FOR ESSENTIAL TREMOR USING TREMOROGRAPHY
Background: Essential tremor is one of the most prevalent extrapyramidal disorders, while treatment efficacy in such patients remains low. Clinical polymorphism of essential tremor requires a differentiated treatment approach, that should be implemented with consideration of objective tremor parame...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
MONIKI
2016-07-01
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| Series: | Alʹmanah Kliničeskoj Mediciny |
| Subjects: | |
| Online Access: | https://www.almclinmed.ru/jour/article/view/356 |
| Summary: | Background: Essential tremor is one of the most prevalent extrapyramidal disorders, while treatment efficacy in such patients remains low. Clinical polymorphism of essential tremor requires a differentiated treatment approach, that should be implemented with consideration of objective tremor parameters. Aim: To study efficacy of treatment of essential tremor based on tremorography. Materials and methods: We followed up 85 patients with essential tremor (mean age, 69.05±1.2 years) who were treated with anticonvulsants as monotherapy (primidone or topiramate), or with combination treatment with non-selective beta-blockers (propranolol), anxiolytics (hydroxizine, etifoxine) and aminophenylbutyric acid. During the treatment, we assessed changes in functional status by Fahn-Tolosa-Marin Tremor Severity Scale and by tremorography. Results: Under treatment with primidone, there was a decrease in global tremor assessment of postural tremor (p=0.036) and of action tremor (p=0.001). During treatment with topiramate, there was a decrease in global tremor assessment in all tests performed (p<0.0002). Non-specific treatment (anxiolytics) exerted a positive effect on the functional state of patients with essential tremor. Conclusion: Tremor amplitude and duration are the objective parameters that define its severity. The treatment guidelines for essential tremor in the elderly patients have been developed. |
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| ISSN: | 2072-0505 2587-9294 |