The Journey of Human Transthyretin: Synthesis, Structure Stability, and Catabolism

The Journey of Human Transthyretin: Synthesis, Structure Stability, and Catabolism

Transthyretin (TTR) is a homotetrameric protein mainly synthesised by the liver and the choroid plexus whose function is to carry the thyroid hormone thyroxine and the retinol-binding protein bound to retinol in plasma and cerebrospinal fluid. When the stability of the tetrameric structure is lost,...

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Bibliographic Details
Main Authors: Chiara Sanguinetti, Marianna Minniti, Vanessa Susini, Laura Caponi, Giorgia Panichella, Vincenzo Castiglione, Alberto Aimo, Michele Emdin, Giuseppe Vergaro, Maria Franzini
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomedicines
Subjects:
transthyretin
TTR amyloidosis
retinol-binding protein
thyroxine
retinol
TTR clearance
Online Access:https://www.mdpi.com/2227-9059/10/8/1906

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