Correlation between Selenium and Zinc Levels and Survival among Prostate Cancer Patients
The most prevalent type of cancer among males is prostate cancer. Survival is considered quite good, but it can be further improved when risk factors are optimized. One of these factors is micronutrients, including Se and Zn. To our knowledge, the interaction between Se and Zn and prostate cancer re...
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| Format: | Article |
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MDPI AG
2024-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/16/4/527 |
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| author | Sandra Pietrzak Wojciech Marciniak Róża Derkacz Milena Matuszczak Adam Kiljańczyk Piotr Baszuk Marta Bryśkiewicz Andrzej Sikorski Jacek Gronwald Marcin Słojewski Cezary Cybulski Adam Gołąb Tomasz Huzarski Tadeusz Dębniak Marcin R. Lener Anna Jakubowska Tomasz Kluz Rodney J. Scott Jan Lubiński |
| author_facet | Sandra Pietrzak Wojciech Marciniak Róża Derkacz Milena Matuszczak Adam Kiljańczyk Piotr Baszuk Marta Bryśkiewicz Andrzej Sikorski Jacek Gronwald Marcin Słojewski Cezary Cybulski Adam Gołąb Tomasz Huzarski Tadeusz Dębniak Marcin R. Lener Anna Jakubowska Tomasz Kluz Rodney J. Scott Jan Lubiński |
| author_sort | Sandra Pietrzak |
| collection | DOAJ |
| description | The most prevalent type of cancer among males is prostate cancer. Survival is considered quite good, but it can be further improved when risk factors are optimized. One of these factors is micronutrients, including Se and Zn. To our knowledge, the interaction between Se and Zn and prostate cancer remains undescribed. This study aimed to investigate the optimal levels of selenium (Se) and zinc (Zn) and their impact on the survival of individuals diagnosed with prostate cancer. A total of 338 prostate cancer patients were enrolled in this study, which was conducted in Poland between 2009 and 2015. Mass spectrometry, which uses inductively coupled plasma mass, was used to assess serum element levels before treatment. The study participants were categorized into quartiles (QI-QIV) based on the distributions of Se and Zn levels observed among surviving participants. Cox regression was used to assess the association between serum Se and Zn levels and the survival of prostate cancer patients. Our results reveal the effect of combined Se and Zn levels on survival in prostate cancer patients (SeQI-ZnQI vs. SeQIV-ZnQIV; HR = 20.9). These results need further research to establish Se/Zn norms for different populations. |
| first_indexed | 2024-03-07T22:18:49Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-07T22:18:49Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-b796bf90c35d45769fdf08f1b477e8e12024-02-23T15:29:59ZengMDPI AGNutrients2072-66432024-02-0116452710.3390/nu16040527Correlation between Selenium and Zinc Levels and Survival among Prostate Cancer PatientsSandra Pietrzak0Wojciech Marciniak1Róża Derkacz2Milena Matuszczak3Adam Kiljańczyk4Piotr Baszuk5Marta Bryśkiewicz6Andrzej Sikorski7Jacek Gronwald8Marcin Słojewski9Cezary Cybulski10Adam Gołąb11Tomasz Huzarski12Tadeusz Dębniak13Marcin R. Lener14Anna Jakubowska15Tomasz Kluz16Rodney J. Scott17Jan Lubiński18Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandRead-Gene, Grzepnica, ul. Alabastrowa 8, 72-003 Dobra, PolandRead-Gene, Grzepnica, ul. Alabastrowa 8, 72-003 Dobra, PolandDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandDepartment of Urology and Urological Oncology, Pomeranian Medical University in Szczecin, al. Powstańców Wielkopolskich 72, 71-899 Szczecin, PolandDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandDepartment of Urology and Urological Oncology, Pomeranian Medical University in Szczecin, al. Powstańców Wielkopolskich 72, 71-899 Szczecin, PolandDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandDepartment of Urology and Urological Oncology, Pomeranian Medical University in Szczecin, al. Powstańców Wielkopolskich 72, 71-899 Szczecin, PolandDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandDepartment of Gynecology, Gynecology Oncology and Obstetrics, Fryderyk Chopin University Hospital No. 1, 35-055 Rzeszow, PolandPriority Research Centre for Cancer Research, Innovation and Translation, Hunter Medical Research Institute, New Lambton, NSW 2305, AustraliaDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandThe most prevalent type of cancer among males is prostate cancer. Survival is considered quite good, but it can be further improved when risk factors are optimized. One of these factors is micronutrients, including Se and Zn. To our knowledge, the interaction between Se and Zn and prostate cancer remains undescribed. This study aimed to investigate the optimal levels of selenium (Se) and zinc (Zn) and their impact on the survival of individuals diagnosed with prostate cancer. A total of 338 prostate cancer patients were enrolled in this study, which was conducted in Poland between 2009 and 2015. Mass spectrometry, which uses inductively coupled plasma mass, was used to assess serum element levels before treatment. The study participants were categorized into quartiles (QI-QIV) based on the distributions of Se and Zn levels observed among surviving participants. Cox regression was used to assess the association between serum Se and Zn levels and the survival of prostate cancer patients. Our results reveal the effect of combined Se and Zn levels on survival in prostate cancer patients (SeQI-ZnQI vs. SeQIV-ZnQIV; HR = 20.9). These results need further research to establish Se/Zn norms for different populations.https://www.mdpi.com/2072-6643/16/4/527seleniumzincprostate cancersurvival |
| spellingShingle | Sandra Pietrzak Wojciech Marciniak Róża Derkacz Milena Matuszczak Adam Kiljańczyk Piotr Baszuk Marta Bryśkiewicz Andrzej Sikorski Jacek Gronwald Marcin Słojewski Cezary Cybulski Adam Gołąb Tomasz Huzarski Tadeusz Dębniak Marcin R. Lener Anna Jakubowska Tomasz Kluz Rodney J. Scott Jan Lubiński Correlation between Selenium and Zinc Levels and Survival among Prostate Cancer Patients Nutrients selenium zinc prostate cancer survival |
| title | Correlation between Selenium and Zinc Levels and Survival among Prostate Cancer Patients |
| title_full | Correlation between Selenium and Zinc Levels and Survival among Prostate Cancer Patients |
| title_fullStr | Correlation between Selenium and Zinc Levels and Survival among Prostate Cancer Patients |
| title_full_unstemmed | Correlation between Selenium and Zinc Levels and Survival among Prostate Cancer Patients |
| title_short | Correlation between Selenium and Zinc Levels and Survival among Prostate Cancer Patients |
| title_sort | correlation between selenium and zinc levels and survival among prostate cancer patients |
| topic | selenium zinc prostate cancer survival |
| url | https://www.mdpi.com/2072-6643/16/4/527 |
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