Hepatoprotective effects of methanolic extract of Alcea rosea against acetaminophen-induced hepatotoxicity in mice
The aim of this study was to evaluate the hepatoprotective effects of Alcea rosea against acetaminophen-induced hepatotoxicity in mice. Aqueous methanolic extract of A. rosea were given orally for 7 consecutive days followed by daily toxic dose of acetaminophen. At the end of treatment period, evalu...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2014-07-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/19068 |
| _version_ | 1818163412429963264 |
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| author | Liaqat Hussain Muhammad Sajid Hamid Akash Madeha Tahir Kanwal Rehman Khwaja Zafar Ahmed |
| author_facet | Liaqat Hussain Muhammad Sajid Hamid Akash Madeha Tahir Kanwal Rehman Khwaja Zafar Ahmed |
| author_sort | Liaqat Hussain |
| collection | DOAJ |
| description | The aim of this study was to evaluate the hepatoprotective effects of Alcea rosea against acetaminophen-induced hepatotoxicity in mice. Aqueous methanolic extract of A. rosea were given orally for 7 consecutive days followed by daily toxic dose of acetaminophen. At the end of treatment period, evaluation of hepatoprotective activity of A. rosea was done on basis of levels of liver enzyme markers (aminotransferases, alkaline phosphatase and bilirubin) and histopathological examination of liver tissues. Acetaminophen significantly increased serum levels of liver enzyme markers whereas, the extract of A. rosea significantly reduced serum levels of elevated liver enzyme markers in dose-dependent manner compared to acetaminophen treated mice group. Histopathological examination of liver tissues also supported the protective effects of A. rosea on liver enzyme markers. We conclude that extract of A. rosea has strong hepatoprotective effects against acetaminophen-induced hepatotoxicity; thereby, affirming its traditional therapeutic role in liver injury. |
| first_indexed | 2024-12-11T16:49:09Z |
| format | Article |
| id | doaj.art-b7979f2f47c14a09a25dff0d2a8cfdaf |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-11T16:49:09Z |
| publishDate | 2014-07-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-b7979f2f47c14a09a25dff0d2a8cfdaf2022-12-22T00:58:09ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882014-07-0193Hepatoprotective effects of methanolic extract of Alcea rosea against acetaminophen-induced hepatotoxicity in miceLiaqat Hussain0Muhammad Sajid Hamid Akash1Madeha Tahir2Kanwal Rehman3Khwaja Zafar Ahmed4Faculty of Pharmaceutical Sciences, Government College University Faisalabad, FaisalabadInstitute of Pharmacology, Toxicology, and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058Faculty of Pharmaceutical Sciences, Government College University Faisalabad, FaisalabadDepartment of Toxicology, School of Medicine and Public Health, Zhejiang University, HangzhouFaculty of Pharmaceutical Sciences, Government College University Faisalabad, FaisalabadThe aim of this study was to evaluate the hepatoprotective effects of Alcea rosea against acetaminophen-induced hepatotoxicity in mice. Aqueous methanolic extract of A. rosea were given orally for 7 consecutive days followed by daily toxic dose of acetaminophen. At the end of treatment period, evaluation of hepatoprotective activity of A. rosea was done on basis of levels of liver enzyme markers (aminotransferases, alkaline phosphatase and bilirubin) and histopathological examination of liver tissues. Acetaminophen significantly increased serum levels of liver enzyme markers whereas, the extract of A. rosea significantly reduced serum levels of elevated liver enzyme markers in dose-dependent manner compared to acetaminophen treated mice group. Histopathological examination of liver tissues also supported the protective effects of A. rosea on liver enzyme markers. We conclude that extract of A. rosea has strong hepatoprotective effects against acetaminophen-induced hepatotoxicity; thereby, affirming its traditional therapeutic role in liver injury.https://www.banglajol.info/index.php/BJP/article/view/19068AcetaminophenAlcea roseaBilirubinHepatotoxicityLiver enzyme marker |
| spellingShingle | Liaqat Hussain Muhammad Sajid Hamid Akash Madeha Tahir Kanwal Rehman Khwaja Zafar Ahmed Hepatoprotective effects of methanolic extract of Alcea rosea against acetaminophen-induced hepatotoxicity in mice Bangladesh Journal of Pharmacology Acetaminophen Alcea rosea Bilirubin Hepatotoxicity Liver enzyme marker |
| title | Hepatoprotective effects of methanolic extract of Alcea rosea against acetaminophen-induced hepatotoxicity in mice |
| title_full | Hepatoprotective effects of methanolic extract of Alcea rosea against acetaminophen-induced hepatotoxicity in mice |
| title_fullStr | Hepatoprotective effects of methanolic extract of Alcea rosea against acetaminophen-induced hepatotoxicity in mice |
| title_full_unstemmed | Hepatoprotective effects of methanolic extract of Alcea rosea against acetaminophen-induced hepatotoxicity in mice |
| title_short | Hepatoprotective effects of methanolic extract of Alcea rosea against acetaminophen-induced hepatotoxicity in mice |
| title_sort | hepatoprotective effects of methanolic extract of alcea rosea against acetaminophen induced hepatotoxicity in mice |
| topic | Acetaminophen Alcea rosea Bilirubin Hepatotoxicity Liver enzyme marker |
| url | https://www.banglajol.info/index.php/BJP/article/view/19068 |
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