TREK-1 in the heart: Potential physiological and pathophysiological roles
The TREK-1 channel belongs to the TREK subfamily of two-pore domains channels that are activated by stretch and polyunsaturated fatty acids and inactivated by Protein Kinase A phosphorylation. The activation of this potassium channel must induce a hyperpolarization of the resting membrane potential...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.1095102/full |
| _version_ | 1797979124608794624 |
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| author | Emilie Bechard Jamie Bride Jean-Yves Le Guennec Fabien Brette Marie Demion |
| author_facet | Emilie Bechard Jamie Bride Jean-Yves Le Guennec Fabien Brette Marie Demion |
| author_sort | Emilie Bechard |
| collection | DOAJ |
| description | The TREK-1 channel belongs to the TREK subfamily of two-pore domains channels that are activated by stretch and polyunsaturated fatty acids and inactivated by Protein Kinase A phosphorylation. The activation of this potassium channel must induce a hyperpolarization of the resting membrane potential and a shortening of the action potential duration in neurons and cardiac cells, two phenomena being beneficial for these tissues in pathological situations like ischemia-reperfusion. Surprisingly, the physiological role of TREK-1 in cardiac function has never been thoroughly investigated, very likely because of the lack of a specific inhibitor. However, possible roles have been unraveled in pathological situations such as atrial fibrillation worsened by heart failure, right ventricular outflow tract tachycardia or pulmonary arterial hypertension. The inhomogeneous distribution of TREK-1 channel within the heart reinforces the idea that this stretch-activated potassium channel might play a role in cardiac areas where the mechanical constraints are important and need a particular protection afforded by TREK-1. Consequently, the main purpose of this mini review is to discuss the possible role played by TREK -1 in physiological and pathophysiological conditions and its potential role in mechano-electrical feedback. Improved understanding of the role of TREK-1 in the heart may help the development of promising treatments for challenging cardiac diseases. |
| first_indexed | 2024-04-11T05:34:05Z |
| format | Article |
| id | doaj.art-b798a5deea3047249dd678bb716180e7 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-11T05:34:05Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-b798a5deea3047249dd678bb716180e72022-12-22T15:56:27ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-12-011310.3389/fphys.2022.10951021095102TREK-1 in the heart: Potential physiological and pathophysiological rolesEmilie BechardJamie BrideJean-Yves Le GuennecFabien BretteMarie DemionThe TREK-1 channel belongs to the TREK subfamily of two-pore domains channels that are activated by stretch and polyunsaturated fatty acids and inactivated by Protein Kinase A phosphorylation. The activation of this potassium channel must induce a hyperpolarization of the resting membrane potential and a shortening of the action potential duration in neurons and cardiac cells, two phenomena being beneficial for these tissues in pathological situations like ischemia-reperfusion. Surprisingly, the physiological role of TREK-1 in cardiac function has never been thoroughly investigated, very likely because of the lack of a specific inhibitor. However, possible roles have been unraveled in pathological situations such as atrial fibrillation worsened by heart failure, right ventricular outflow tract tachycardia or pulmonary arterial hypertension. The inhomogeneous distribution of TREK-1 channel within the heart reinforces the idea that this stretch-activated potassium channel might play a role in cardiac areas where the mechanical constraints are important and need a particular protection afforded by TREK-1. Consequently, the main purpose of this mini review is to discuss the possible role played by TREK -1 in physiological and pathophysiological conditions and its potential role in mechano-electrical feedback. Improved understanding of the role of TREK-1 in the heart may help the development of promising treatments for challenging cardiac diseases.https://www.frontiersin.org/articles/10.3389/fphys.2022.1095102/fullTREK-1K2P2.1atrial fibrillationmyocardial infarctionRVOT |
| spellingShingle | Emilie Bechard Jamie Bride Jean-Yves Le Guennec Fabien Brette Marie Demion TREK-1 in the heart: Potential physiological and pathophysiological roles Frontiers in Physiology TREK-1 K2P2.1 atrial fibrillation myocardial infarction RVOT |
| title | TREK-1 in the heart: Potential physiological and pathophysiological roles |
| title_full | TREK-1 in the heart: Potential physiological and pathophysiological roles |
| title_fullStr | TREK-1 in the heart: Potential physiological and pathophysiological roles |
| title_full_unstemmed | TREK-1 in the heart: Potential physiological and pathophysiological roles |
| title_short | TREK-1 in the heart: Potential physiological and pathophysiological roles |
| title_sort | trek 1 in the heart potential physiological and pathophysiological roles |
| topic | TREK-1 K2P2.1 atrial fibrillation myocardial infarction RVOT |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.1095102/full |
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