Synthesis of bis-spirocyclic derivatives of 3-azabicyclo[3.1.0]hexane via cyclopropene cycloadditions to the stable azomethine ylide derived from Ruhemann's purple

Synthesis of bis-spirocyclic derivatives of 3-azabicyclo[3.1.0]hexane via cyclopropene cycloadditions to the stable azomethine ylide derived from Ruhemann's purple

A reliable method for the synthesis of bis-spirocyclic derivatives of 3-azabicyclo[3.1.0]hexanes through the 1,3-dipolar cycloaddition (1,3-DC) reactions of cyclopropenes to the stable azomethine ylide – protonated form of Ruhemann's purple (PRP) has been developed. Both 3-substituted and 3,3-d...

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Bibliographic Details
Main Authors: Alexander S. Filatov, Olesya V. Khoroshilova, Anna G. Larina, Vitali M. Boitsov, Alexander V. Stepakov
Format: Article
Language:English
Published: Beilstein-Institut 2022-06-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
azomethine ylides
cycloaddition
cyclopropenes
dft calculations
spiro heterocycles
Online Access:https://doi.org/10.3762/bjoc.18.77

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