Scoring Osteoarthritis Reliably in Large Joints and the Spine Using Whole-Body CT: OsteoArthritis Computed Tomography-Score (OACT-Score)
A standardized method to assess structural osteoarthritis (OA) burden thorough the body lacks from literature. Such a method can be valuable in developing personalized treatments for OA. We developed a reliable scoring system to evaluate OA in large joints and the spine—the OsteoArthritis Computed T...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
|
| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/11/1/5 |
| _version_ | 1797543870285742080 |
|---|---|
| author | Willem Paul Gielis Harrie Weinans Frank J. Nap Frank W. Roemer Wouter Foppen |
| author_facet | Willem Paul Gielis Harrie Weinans Frank J. Nap Frank W. Roemer Wouter Foppen |
| author_sort | Willem Paul Gielis |
| collection | DOAJ |
| description | A standardized method to assess structural osteoarthritis (OA) burden thorough the body lacks from literature. Such a method can be valuable in developing personalized treatments for OA. We developed a reliable scoring system to evaluate OA in large joints and the spine—the OsteoArthritis Computed Tomography (OACT) score, using a convenience sample of 197 whole-body low-dose non-contrast CTs. An atlas, containing example images as reference points for training and scoring, are presented. Each joint was graded between 0–3. The total OA burden was calculated by summing scores of individual joints. Intra- and inter-observer reliability was tested 25 randomly selected scans (<i>N</i> = 600 joints). Intra-observer reliability and inter-observer reliability between three observers was assessed using intraclass correlation coefficient (ICC) and square-weighted kappa statistics. The square-weighted kappa for intra-observer reliability for OACT-score at joint-level ranged from 0.79 to 0.95; the ICC for the total OA grade was 0.97 (95%-CI, 0.94 to 0.99). Square-weighted kappa for interobserver reliability ranged from 0.48 to 0.95; the ICC for the total OA grade was 0.95 (95%-CI, 0.90 to 0.98). The OACT score, a new reproducible CT-based grading system reflecting OA burden in large joints and the spine, has a satisfactory reproducibility. The atlas can be used for research purposes, training, educational purposes and systemic grading of OA on CT-scans. |
| first_indexed | 2024-03-10T13:51:43Z |
| format | Article |
| id | doaj.art-b799e9e581714c79ae8a7f039f8f8746 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T13:51:43Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-b799e9e581714c79ae8a7f039f8f87462023-11-21T02:05:05ZengMDPI AGJournal of Personalized Medicine2075-44262020-12-01111510.3390/jpm11010005Scoring Osteoarthritis Reliably in Large Joints and the Spine Using Whole-Body CT: OsteoArthritis Computed Tomography-Score (OACT-Score)Willem Paul Gielis0Harrie Weinans1Frank J. Nap2Frank W. Roemer3Wouter Foppen4Department of Orthopaedics, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The NetherlandsDepartment of Orthopaedics, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The NetherlandsDepartment of Radiology, Central Military Hospital (CMH) Utrecht, 3584 CX Utrecht, The NetherlandsDepartment of Radiology, Friedrich-Alexander University Erlangen-Nürnberg & Universitätsklinikum Erlangen, 91054 Erlangen, GermanyDepartment of Radiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The NetherlandsA standardized method to assess structural osteoarthritis (OA) burden thorough the body lacks from literature. Such a method can be valuable in developing personalized treatments for OA. We developed a reliable scoring system to evaluate OA in large joints and the spine—the OsteoArthritis Computed Tomography (OACT) score, using a convenience sample of 197 whole-body low-dose non-contrast CTs. An atlas, containing example images as reference points for training and scoring, are presented. Each joint was graded between 0–3. The total OA burden was calculated by summing scores of individual joints. Intra- and inter-observer reliability was tested 25 randomly selected scans (<i>N</i> = 600 joints). Intra-observer reliability and inter-observer reliability between three observers was assessed using intraclass correlation coefficient (ICC) and square-weighted kappa statistics. The square-weighted kappa for intra-observer reliability for OACT-score at joint-level ranged from 0.79 to 0.95; the ICC for the total OA grade was 0.97 (95%-CI, 0.94 to 0.99). Square-weighted kappa for interobserver reliability ranged from 0.48 to 0.95; the ICC for the total OA grade was 0.95 (95%-CI, 0.90 to 0.98). The OACT score, a new reproducible CT-based grading system reflecting OA burden in large joints and the spine, has a satisfactory reproducibility. The atlas can be used for research purposes, training, educational purposes and systemic grading of OA on CT-scans.https://www.mdpi.com/2075-4426/11/1/5computed tomographyimage analysisosteoarthritisreliability |
| spellingShingle | Willem Paul Gielis Harrie Weinans Frank J. Nap Frank W. Roemer Wouter Foppen Scoring Osteoarthritis Reliably in Large Joints and the Spine Using Whole-Body CT: OsteoArthritis Computed Tomography-Score (OACT-Score) Journal of Personalized Medicine computed tomography image analysis osteoarthritis reliability |
| title | Scoring Osteoarthritis Reliably in Large Joints and the Spine Using Whole-Body CT: OsteoArthritis Computed Tomography-Score (OACT-Score) |
| title_full | Scoring Osteoarthritis Reliably in Large Joints and the Spine Using Whole-Body CT: OsteoArthritis Computed Tomography-Score (OACT-Score) |
| title_fullStr | Scoring Osteoarthritis Reliably in Large Joints and the Spine Using Whole-Body CT: OsteoArthritis Computed Tomography-Score (OACT-Score) |
| title_full_unstemmed | Scoring Osteoarthritis Reliably in Large Joints and the Spine Using Whole-Body CT: OsteoArthritis Computed Tomography-Score (OACT-Score) |
| title_short | Scoring Osteoarthritis Reliably in Large Joints and the Spine Using Whole-Body CT: OsteoArthritis Computed Tomography-Score (OACT-Score) |
| title_sort | scoring osteoarthritis reliably in large joints and the spine using whole body ct osteoarthritis computed tomography score oact score |
| topic | computed tomography image analysis osteoarthritis reliability |
| url | https://www.mdpi.com/2075-4426/11/1/5 |
| work_keys_str_mv | AT willempaulgielis scoringosteoarthritisreliablyinlargejointsandthespineusingwholebodyctosteoarthritiscomputedtomographyscoreoactscore AT harrieweinans scoringosteoarthritisreliablyinlargejointsandthespineusingwholebodyctosteoarthritiscomputedtomographyscoreoactscore AT frankjnap scoringosteoarthritisreliablyinlargejointsandthespineusingwholebodyctosteoarthritiscomputedtomographyscoreoactscore AT frankwroemer scoringosteoarthritisreliablyinlargejointsandthespineusingwholebodyctosteoarthritiscomputedtomographyscoreoactscore AT wouterfoppen scoringosteoarthritisreliablyinlargejointsandthespineusingwholebodyctosteoarthritiscomputedtomographyscoreoactscore |