Hepatotoxicity and antioxidant activity of some new N,N′-disubstituted benzimidazole-2-thiones, radical scavenging mechanism and structure-activity relationship

Hepatotoxicity and antioxidant activity of some new N,N′-disubstituted benzimidazole-2-thiones, radical scavenging mechanism and structure-activity relationship

A new method for the synthesis of 1,3-disubstituted benzimidazole derivatives was developed using aza-Michael addition. The target compounds were synthesized in good yields and purity and tested on isolated hepatocytes for their toxicity and antioxidant activity. The antioxidant properties of the su...

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Bibliographic Details
Main Authors: Neda O. Anastassova, Anelia Ts. Mavrova, Denitsa Y. Yancheva, Magdalena S. Kondeva-Burdina, Virginia I. Tzankova, Simeon S. Stoyanov, Boris L. Shivachev, Rositsa P. Nikolova
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Arabian Journal of Chemistry
Subjects:
1,3-Disubstituted benzimidazole-2-thiones
Michael addition
Hepatotoxicity
Oxidative stress
Radical scavenging
DFT calculations
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535216302362

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