To Determine the Role of Co-Enzyme Q10 and Trace Elements in Patient with Pre-Eclampsia - A Cross Sectional Study in Hyderabad
OBJECTIVE: The pre-eclampsia is most common hypertensive and life threatening disorder during pregnancy. Abnormal placenta may be involved in the pathogenesis of pre-eclampsia. Co-Enzyme Q10 and trace elements has been proposed as novel factors concerned in development of pre-eclampsia. STUDY DESIG...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Liaquat University of Medical and Health Sciences
2017-06-01
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| Series: | JLUMHS |
| Subjects: |
| _version_ | 1797768157509713920 |
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| author | Farheen Shaikh Tazeen Shah Shafaq Ansari Sanum Dahri |
| author_facet | Farheen Shaikh Tazeen Shah Shafaq Ansari Sanum Dahri |
| author_sort | Farheen Shaikh |
| collection | DOAJ |
| description | OBJECTIVE: The pre-eclampsia is most common hypertensive and life threatening disorder during pregnancy. Abnormal placenta may be involved in the pathogenesis of pre-eclampsia. Co-Enzyme Q10 and trace elements has been proposed as novel factors concerned in development of pre-eclampsia.
STUDY DESIGN: Cross sectional, comparative study
SETTING: Study was conducted in Biochemistry department Liaquat University of Medical & Health Sciences Jamshoro and patients were recruited from department of Obstetrics & Gynecology Liaquat University Hospital Jamshoro / Hyderabad
DURATION: 1st February 2015 to 30th October 2015.
METHODS: Total 210 volunteers were recruited, from which 50 volunteers were normotensive healthy pregnant women as a control and 160 were pre-eclamptic patients as cases. The subjects were recruited based on sign and symptoms, taking obstetric history, anthropometric, clinical data and collecting blood sample from volunteers. The CoQ10 was evaluated on HPLC while zinc, copper and magnesium on Atomic Absorption Spectrophotometer.
RESULTS: The plasma Co-Enzyme Q10 levelwere found decreased in pre-eclamptic patients (mean ±S.D) (0.22±0.09)μg/dl as compared with control group(1.08±0.37) μg/dl with significant difference of p<0.05. Serum zinc, copper and magnesiumlevels in pre-eclampsia were decreased significanlty, it was noted as (2.94±0.44), Cu++ (0.19±0.09) and Mg++(1.16 ± 0.08)mg/dl as compared with normotensive women (5.09±0.29), (0.36± 0.03) and (2.15± 0.09) mg/dl with significant difference of p<0.05 respectively.
CONCLUSION: The observation showed that the CoQ10 and trace elements are essential for the healthy pregnancy, declined oncentration of CoQ10 and essential trace elements may put forward the possible involvement in the pathology of pre-eclampsia. |
| first_indexed | 2024-03-12T20:49:30Z |
| format | Article |
| id | doaj.art-b79c64a8bae14e4f9375b83d468150f8 |
| institution | Directory Open Access Journal |
| issn | 1729-0341 2309-8627 |
| language | English |
| last_indexed | 2024-03-12T20:49:30Z |
| publishDate | 2017-06-01 |
| publisher | Liaquat University of Medical and Health Sciences |
| record_format | Article |
| series | JLUMHS |
| spelling | doaj.art-b79c64a8bae14e4f9375b83d468150f82023-08-01T06:06:28ZengLiaquat University of Medical and Health SciencesJLUMHS1729-03412309-86272017-06-011602869210.22442/jlumhs.171620512To Determine the Role of Co-Enzyme Q10 and Trace Elements in Patient with Pre-Eclampsia - A Cross Sectional Study in HyderabadFarheen Shaikh 0Tazeen Shah1Shafaq Ansari2 Sanum Dahri3Liaquat University of Medical & Health Sciences (LUMHS), Jamshoro, Sindh-PakistanLiaquat University of Medical & Health Sciences (LUMHS), Jamshoro, Sindh-PakistanLiaquat University of Medical & Health Sciences (LUMHS), Jamshoro, Sindh-PakistanBasic Medical Sciences Institute Jinnah Postgraduate Medical Center Karachi, Sindh-Pakistan. OBJECTIVE: The pre-eclampsia is most common hypertensive and life threatening disorder during pregnancy. Abnormal placenta may be involved in the pathogenesis of pre-eclampsia. Co-Enzyme Q10 and trace elements has been proposed as novel factors concerned in development of pre-eclampsia. STUDY DESIGN: Cross sectional, comparative study SETTING: Study was conducted in Biochemistry department Liaquat University of Medical & Health Sciences Jamshoro and patients were recruited from department of Obstetrics & Gynecology Liaquat University Hospital Jamshoro / Hyderabad DURATION: 1st February 2015 to 30th October 2015. METHODS: Total 210 volunteers were recruited, from which 50 volunteers were normotensive healthy pregnant women as a control and 160 were pre-eclamptic patients as cases. The subjects were recruited based on sign and symptoms, taking obstetric history, anthropometric, clinical data and collecting blood sample from volunteers. The CoQ10 was evaluated on HPLC while zinc, copper and magnesium on Atomic Absorption Spectrophotometer. RESULTS: The plasma Co-Enzyme Q10 levelwere found decreased in pre-eclamptic patients (mean ±S.D) (0.22±0.09)μg/dl as compared with control group(1.08±0.37) μg/dl with significant difference of p<0.05. Serum zinc, copper and magnesiumlevels in pre-eclampsia were decreased significanlty, it was noted as (2.94±0.44), Cu++ (0.19±0.09) and Mg++(1.16 ± 0.08)mg/dl as compared with normotensive women (5.09±0.29), (0.36± 0.03) and (2.15± 0.09) mg/dl with significant difference of p<0.05 respectively. CONCLUSION: The observation showed that the CoQ10 and trace elements are essential for the healthy pregnancy, declined oncentration of CoQ10 and essential trace elements may put forward the possible involvement in the pathology of pre-eclampsia.pre-eclampsiaco-enzyme q10magnesiumcopperzinchigh liquid chromatography |
| spellingShingle | Farheen Shaikh Tazeen Shah Shafaq Ansari Sanum Dahri To Determine the Role of Co-Enzyme Q10 and Trace Elements in Patient with Pre-Eclampsia - A Cross Sectional Study in Hyderabad JLUMHS pre-eclampsia co-enzyme q10 magnesium copper zinc high liquid chromatography |
| title | To Determine the Role of Co-Enzyme Q10 and Trace Elements in Patient with Pre-Eclampsia - A Cross Sectional Study in Hyderabad |
| title_full | To Determine the Role of Co-Enzyme Q10 and Trace Elements in Patient with Pre-Eclampsia - A Cross Sectional Study in Hyderabad |
| title_fullStr | To Determine the Role of Co-Enzyme Q10 and Trace Elements in Patient with Pre-Eclampsia - A Cross Sectional Study in Hyderabad |
| title_full_unstemmed | To Determine the Role of Co-Enzyme Q10 and Trace Elements in Patient with Pre-Eclampsia - A Cross Sectional Study in Hyderabad |
| title_short | To Determine the Role of Co-Enzyme Q10 and Trace Elements in Patient with Pre-Eclampsia - A Cross Sectional Study in Hyderabad |
| title_sort | to determine the role of co enzyme q10 and trace elements in patient with pre eclampsia a cross sectional study in hyderabad |
| topic | pre-eclampsia co-enzyme q10 magnesium copper zinc high liquid chromatography |
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