Comparative metabolic profiling of posterior parietal cortex, amygdala, and hippocampus in conditioned fear memory
Abstract Fear conditioning and retrieval are suitable models to investigate the biological basis of various mental disorders. Hippocampus and amygdala neurons consolidate conditioned stimulus (CS)-dependent fear memory. Posterior parietal cortex is considered important for the CS-dependent condition...
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | Molecular Brain |
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| Online Access: | https://doi.org/10.1186/s13041-021-00863-x |
| _version_ | 1819026907548614656 |
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| author | Yoonjeong Jeon Yun Lim Jiwoo Yeom Eun-Kyoung Kim |
| author_facet | Yoonjeong Jeon Yun Lim Jiwoo Yeom Eun-Kyoung Kim |
| author_sort | Yoonjeong Jeon |
| collection | DOAJ |
| description | Abstract Fear conditioning and retrieval are suitable models to investigate the biological basis of various mental disorders. Hippocampus and amygdala neurons consolidate conditioned stimulus (CS)-dependent fear memory. Posterior parietal cortex is considered important for the CS-dependent conditioning and retrieval of fear memory. Metabolomic screening among functionally related brain areas provides molecular signatures and biomarkers to improve the treatment of psychopathologies. Herein, we analyzed and compared changes of metabolites in the hippocampus, amygdala, and posterior parietal cortex under the fear retrieval condition. Metabolite profiles of posterior parietal cortex and amygdala were similarly changed after fear memory retrieval. While the retrieval of fear memory perturbed various metabolic pathways, most metabolic pathways that overlapped among the three brain regions had high ranks in the enrichment analysis of posterior parietal cortex. In posterior parietal cortex, the most perturbed pathways were pantothenate and CoA biosynthesis, purine metabolism, glutathione metabolism, and NAD+ dependent signaling. Metabolites of posterior parietal cortex including 4′-phosphopantetheine, xanthine, glutathione, ADP-ribose, ADP-ribose 2′-phosphate, and cyclic ADP-ribose were significantly regulated in these metabolic pathways. These results point to the importance of metabolites of posterior parietal cortex in conditioned fear memory retrieval and may provide potential biomarker candidates for traumatic memory-related mental disorders. |
| first_indexed | 2024-12-21T05:34:02Z |
| format | Article |
| id | doaj.art-b79cffe6cf7543fa84dc07ed9de3dea0 |
| institution | Directory Open Access Journal |
| issn | 1756-6606 |
| language | English |
| last_indexed | 2024-12-21T05:34:02Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Brain |
| spelling | doaj.art-b79cffe6cf7543fa84dc07ed9de3dea02022-12-21T19:14:28ZengBMCMolecular Brain1756-66062021-10-0114111410.1186/s13041-021-00863-xComparative metabolic profiling of posterior parietal cortex, amygdala, and hippocampus in conditioned fear memoryYoonjeong Jeon0Yun Lim1Jiwoo Yeom2Eun-Kyoung Kim3Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST)Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST)Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST)Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST)Abstract Fear conditioning and retrieval are suitable models to investigate the biological basis of various mental disorders. Hippocampus and amygdala neurons consolidate conditioned stimulus (CS)-dependent fear memory. Posterior parietal cortex is considered important for the CS-dependent conditioning and retrieval of fear memory. Metabolomic screening among functionally related brain areas provides molecular signatures and biomarkers to improve the treatment of psychopathologies. Herein, we analyzed and compared changes of metabolites in the hippocampus, amygdala, and posterior parietal cortex under the fear retrieval condition. Metabolite profiles of posterior parietal cortex and amygdala were similarly changed after fear memory retrieval. While the retrieval of fear memory perturbed various metabolic pathways, most metabolic pathways that overlapped among the three brain regions had high ranks in the enrichment analysis of posterior parietal cortex. In posterior parietal cortex, the most perturbed pathways were pantothenate and CoA biosynthesis, purine metabolism, glutathione metabolism, and NAD+ dependent signaling. Metabolites of posterior parietal cortex including 4′-phosphopantetheine, xanthine, glutathione, ADP-ribose, ADP-ribose 2′-phosphate, and cyclic ADP-ribose were significantly regulated in these metabolic pathways. These results point to the importance of metabolites of posterior parietal cortex in conditioned fear memory retrieval and may provide potential biomarker candidates for traumatic memory-related mental disorders.https://doi.org/10.1186/s13041-021-00863-xConditioned fear memoryMetabolomicsPosterior parietal cortexAmygdalaHippocampus |
| spellingShingle | Yoonjeong Jeon Yun Lim Jiwoo Yeom Eun-Kyoung Kim Comparative metabolic profiling of posterior parietal cortex, amygdala, and hippocampus in conditioned fear memory Molecular Brain Conditioned fear memory Metabolomics Posterior parietal cortex Amygdala Hippocampus |
| title | Comparative metabolic profiling of posterior parietal cortex, amygdala, and hippocampus in conditioned fear memory |
| title_full | Comparative metabolic profiling of posterior parietal cortex, amygdala, and hippocampus in conditioned fear memory |
| title_fullStr | Comparative metabolic profiling of posterior parietal cortex, amygdala, and hippocampus in conditioned fear memory |
| title_full_unstemmed | Comparative metabolic profiling of posterior parietal cortex, amygdala, and hippocampus in conditioned fear memory |
| title_short | Comparative metabolic profiling of posterior parietal cortex, amygdala, and hippocampus in conditioned fear memory |
| title_sort | comparative metabolic profiling of posterior parietal cortex amygdala and hippocampus in conditioned fear memory |
| topic | Conditioned fear memory Metabolomics Posterior parietal cortex Amygdala Hippocampus |
| url | https://doi.org/10.1186/s13041-021-00863-x |
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