Human induced pluripotent stem cell line ZZUNEUi027-A generated from a long QT syndrome patient with a heterozygous KCNH2 (c. 128 A > G) mutant
Long QT syndrome is one of the most common hereditary arrhythmias. Mutations in KCNH2 can cause long QT syndrome type 2 (LQT2). In this study, we generated a human induced pluripotent stem cell line ZZUNEUi027-A from a LQT2 female patient with c. 128A → G in KCNH2 gene using non-integrative Sendai v...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506122001854 |
| _version_ | 1811342919504756736 |
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| author | Jiangtao Zhao Lu Wang Kui Zhu Xiaowei Chen Fen Qin Xiaowei Li Jianzeng Dong Hailong Tao |
| author_facet | Jiangtao Zhao Lu Wang Kui Zhu Xiaowei Chen Fen Qin Xiaowei Li Jianzeng Dong Hailong Tao |
| author_sort | Jiangtao Zhao |
| collection | DOAJ |
| description | Long QT syndrome is one of the most common hereditary arrhythmias. Mutations in KCNH2 can cause long QT syndrome type 2 (LQT2). In this study, we generated a human induced pluripotent stem cell line ZZUNEUi027-A from a LQT2 female patient with c. 128A → G in KCNH2 gene using non-integrative Sendai viral reprogramming technology. This cell line expresses pluripotency markers, exhibits a normal female karyotype (46, XX) and could differentiate into all three germ layers in vitro. ZZUNEUi027-A can serve as a cell disease model in the understanding of LQT2 pathogenesis. |
| first_indexed | 2024-04-13T19:20:33Z |
| format | Article |
| id | doaj.art-b79e07879ab34023b65bf12ac05ded86 |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-04-13T19:20:33Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-b79e07879ab34023b65bf12ac05ded862022-12-22T02:33:33ZengElsevierStem Cell Research1873-50612022-08-0163102836Human induced pluripotent stem cell line ZZUNEUi027-A generated from a long QT syndrome patient with a heterozygous KCNH2 (c. 128 A > G) mutantJiangtao Zhao0Lu Wang1Kui Zhu2Xiaowei Chen3Fen Qin4Xiaowei Li5Jianzeng Dong6Hailong Tao7Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Henan Key Laboratory of Hereditary Cardiovascular Diseases, Zhengzhou 450052, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Henan Key Laboratory of Hereditary Cardiovascular Diseases, Zhengzhou 450052, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Henan Key Laboratory of Hereditary Cardiovascular Diseases, Zhengzhou 450052, China; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases, No. 2 Beijing Anzhen Road, Chaoyang District, Beijing 100029, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Corresponding author at: The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Longhu Zhonghuan Road No. 1, Jinshui District, Zhengzhou, China.Long QT syndrome is one of the most common hereditary arrhythmias. Mutations in KCNH2 can cause long QT syndrome type 2 (LQT2). In this study, we generated a human induced pluripotent stem cell line ZZUNEUi027-A from a LQT2 female patient with c. 128A → G in KCNH2 gene using non-integrative Sendai viral reprogramming technology. This cell line expresses pluripotency markers, exhibits a normal female karyotype (46, XX) and could differentiate into all three germ layers in vitro. ZZUNEUi027-A can serve as a cell disease model in the understanding of LQT2 pathogenesis.http://www.sciencedirect.com/science/article/pii/S1873506122001854 |
| spellingShingle | Jiangtao Zhao Lu Wang Kui Zhu Xiaowei Chen Fen Qin Xiaowei Li Jianzeng Dong Hailong Tao Human induced pluripotent stem cell line ZZUNEUi027-A generated from a long QT syndrome patient with a heterozygous KCNH2 (c. 128 A > G) mutant Stem Cell Research |
| title | Human induced pluripotent stem cell line ZZUNEUi027-A generated from a long QT syndrome patient with a heterozygous KCNH2 (c. 128 A > G) mutant |
| title_full | Human induced pluripotent stem cell line ZZUNEUi027-A generated from a long QT syndrome patient with a heterozygous KCNH2 (c. 128 A > G) mutant |
| title_fullStr | Human induced pluripotent stem cell line ZZUNEUi027-A generated from a long QT syndrome patient with a heterozygous KCNH2 (c. 128 A > G) mutant |
| title_full_unstemmed | Human induced pluripotent stem cell line ZZUNEUi027-A generated from a long QT syndrome patient with a heterozygous KCNH2 (c. 128 A > G) mutant |
| title_short | Human induced pluripotent stem cell line ZZUNEUi027-A generated from a long QT syndrome patient with a heterozygous KCNH2 (c. 128 A > G) mutant |
| title_sort | human induced pluripotent stem cell line zzuneui027 a generated from a long qt syndrome patient with a heterozygous kcnh2 c 128 a g mutant |
| url | http://www.sciencedirect.com/science/article/pii/S1873506122001854 |
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