Plasma and Urine Indoleamine 2,3-Dioxygenase Activity: Promising Biomarkers for Chronic Kidney Disease and Inflammation Status
Hao Hong,1 Suya Zhou,2 Haimin Shi,3 Ming Li3 1Intensive Care Unit, The First Affiliated Hospital of Soochow University, Soochow, People’s Republic of China; 2Laboratory Nephrology, Department of Nephrology, Jinshan Hospital of Fudan University, Shanghai, People’s Republic of China; 3Laboratory Nephr...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-09-01
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| Series: | Journal of Inflammation Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/plasma-and-urine-indoleamine-23-dioxygenase-activity-promising-biomark-peer-reviewed-fulltext-article-JIR |
| _version_ | 1811209559768825856 |
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| author | Hong H Zhou S Shi H Li M |
| author_facet | Hong H Zhou S Shi H Li M |
| author_sort | Hong H |
| collection | DOAJ |
| description | Hao Hong,1 Suya Zhou,2 Haimin Shi,3 Ming Li3 1Intensive Care Unit, The First Affiliated Hospital of Soochow University, Soochow, People’s Republic of China; 2Laboratory Nephrology, Department of Nephrology, Jinshan Hospital of Fudan University, Shanghai, People’s Republic of China; 3Laboratory Nephrology, The First Affiliated Hospital of Soochow University, Soochow, People’s Republic of ChinaCorrespondence: Ming Li, Tel +86 13656237709, Fax +0512-67972681, Email szdrli@163.comPurpose: Our aim was to determine the relationship between plasma and urine indoleamine 2.3-dioxygenase (IDO) activity and stage of chronic kidney disease (CKD).Patients and Methods: Demographic and clinical parameters, including plasma and urine IDO activity, were recorded in 47 CKD patients and 30 controls. One-way ANOVA with the least significant difference method was used to compare means of variables that had normal distributions and homogeneous variance. Variables with non-normal distributions were log-transformed and compared using the rank sum test Pearson or Spearman correlation coefficients were determined. Binary logistic regression and ordinal logistic regression were used to identify independently significant factors. Receiver operating characteristic (ROC) analysis was performed.Results: The control group had higher levels of hemoglobin and albumin and lower levels of creatinine and blood urea nitrogen (BUN; all P< 0.01). The level of highly sensitive C reactive protein (hs-CRP) increased as CKD stage increased (P |
| first_indexed | 2024-04-12T04:41:37Z |
| format | Article |
| id | doaj.art-b79e1050fa7c43bfb6b977607cb81b3a |
| institution | Directory Open Access Journal |
| issn | 1178-7031 |
| language | English |
| last_indexed | 2024-04-12T04:41:37Z |
| publishDate | 2022-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj.art-b79e1050fa7c43bfb6b977607cb81b3a2022-12-22T03:47:38ZengDove Medical PressJournal of Inflammation Research1178-70312022-09-01Volume 155129513978038Plasma and Urine Indoleamine 2,3-Dioxygenase Activity: Promising Biomarkers for Chronic Kidney Disease and Inflammation StatusHong HZhou SShi HLi MHao Hong,1 Suya Zhou,2 Haimin Shi,3 Ming Li3 1Intensive Care Unit, The First Affiliated Hospital of Soochow University, Soochow, People’s Republic of China; 2Laboratory Nephrology, Department of Nephrology, Jinshan Hospital of Fudan University, Shanghai, People’s Republic of China; 3Laboratory Nephrology, The First Affiliated Hospital of Soochow University, Soochow, People’s Republic of ChinaCorrespondence: Ming Li, Tel +86 13656237709, Fax +0512-67972681, Email szdrli@163.comPurpose: Our aim was to determine the relationship between plasma and urine indoleamine 2.3-dioxygenase (IDO) activity and stage of chronic kidney disease (CKD).Patients and Methods: Demographic and clinical parameters, including plasma and urine IDO activity, were recorded in 47 CKD patients and 30 controls. One-way ANOVA with the least significant difference method was used to compare means of variables that had normal distributions and homogeneous variance. Variables with non-normal distributions were log-transformed and compared using the rank sum test Pearson or Spearman correlation coefficients were determined. Binary logistic regression and ordinal logistic regression were used to identify independently significant factors. Receiver operating characteristic (ROC) analysis was performed.Results: The control group had higher levels of hemoglobin and albumin and lower levels of creatinine and blood urea nitrogen (BUN; all P< 0.01). The level of highly sensitive C reactive protein (hs-CRP) increased as CKD stage increased (Phttps://www.dovepress.com/plasma-and-urine-indoleamine-23-dioxygenase-activity-promising-biomark-peer-reviewed-fulltext-article-JIRtryptophan rate-limiting enzymeinflammatoryhs-crpliquid chromatography-mass spectrometry |
| spellingShingle | Hong H Zhou S Shi H Li M Plasma and Urine Indoleamine 2,3-Dioxygenase Activity: Promising Biomarkers for Chronic Kidney Disease and Inflammation Status Journal of Inflammation Research tryptophan rate-limiting enzyme inflammatory hs-crp liquid chromatography-mass spectrometry |
| title | Plasma and Urine Indoleamine 2,3-Dioxygenase Activity: Promising Biomarkers for Chronic Kidney Disease and Inflammation Status |
| title_full | Plasma and Urine Indoleamine 2,3-Dioxygenase Activity: Promising Biomarkers for Chronic Kidney Disease and Inflammation Status |
| title_fullStr | Plasma and Urine Indoleamine 2,3-Dioxygenase Activity: Promising Biomarkers for Chronic Kidney Disease and Inflammation Status |
| title_full_unstemmed | Plasma and Urine Indoleamine 2,3-Dioxygenase Activity: Promising Biomarkers for Chronic Kidney Disease and Inflammation Status |
| title_short | Plasma and Urine Indoleamine 2,3-Dioxygenase Activity: Promising Biomarkers for Chronic Kidney Disease and Inflammation Status |
| title_sort | plasma and urine indoleamine 2 3 dioxygenase activity promising biomarkers for chronic kidney disease and inflammation status |
| topic | tryptophan rate-limiting enzyme inflammatory hs-crp liquid chromatography-mass spectrometry |
| url | https://www.dovepress.com/plasma-and-urine-indoleamine-23-dioxygenase-activity-promising-biomark-peer-reviewed-fulltext-article-JIR |
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