Liver Transplantation in Patients with Acute-onChronic Liver Failure: Challenging the Limits
Acute-on-chronic liver failure (ACLF) is one of the main causes of death on the waiting list. Liver transplantation (LT) is the only curative treatment for patients with ACLF and therefore it should be considered in all cases. However, the applicability of LT in patients with ACLF is challenging, g...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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European Medical Journal
2021-09-01
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| Series: | European Medical Journal |
| Online Access: | https://www.emjreviews.com/european-medical-journal/article/liver-transplantation-in-patients-with-acute-on-chronic-liver-failure-challenging-the-limits-j190321/ |
| _version_ | 1797193802633445376 |
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| author | Juan Manuel Diaz Ezequiel Mauro Maria Nelly Gutierrez-Acevedo Adrian Gadano Sebastian Marciano |
| author_facet | Juan Manuel Diaz Ezequiel Mauro Maria Nelly Gutierrez-Acevedo Adrian Gadano Sebastian Marciano |
| author_sort | Juan Manuel Diaz |
| collection | DOAJ |
| description |
Acute-on-chronic liver failure (ACLF) is one of the main causes of death on the waiting list. Liver transplantation (LT) is the only curative treatment for patients with ACLF and therefore it should be considered in all cases. However, the applicability of LT in patients with ACLF is challenging, given the scarcity of donors and the high short-term mortality of these patients. Organ allocation has traditionally been prioritised according to the model for end-stage liver disease (MELD) system. However, the accuracy of MELD score is limited in patients with ACLF. In this article, the authors review the outcomes of patients with ACLF before and after LT, highlighting its clinical course, the feasibility of LT in the sickest patients, the role of the organ allocation system, and possible indicators of futility. |
| first_indexed | 2024-04-24T05:46:11Z |
| format | Article |
| id | doaj.art-b79e1893f6ef4ac8b59935a68078c7c0 |
| institution | Directory Open Access Journal |
| issn | 2397-6764 |
| language | English |
| last_indexed | 2024-04-24T05:46:11Z |
| publishDate | 2021-09-01 |
| publisher | European Medical Journal |
| record_format | Article |
| series | European Medical Journal |
| spelling | doaj.art-b79e1893f6ef4ac8b59935a68078c7c02024-04-23T15:52:20ZengEuropean Medical JournalEuropean Medical Journal2397-67642021-09-01616910.33590/emj/21-00040Liver Transplantation in Patients with Acute-onChronic Liver Failure: Challenging the LimitsJuan Manuel Diaz0Ezequiel Mauro1Maria Nelly Gutierrez-Acevedo2Adrian Gadano3Sebastian Marciano4Liver Unit, Hospital Italiano de Buenos Aires, ArgentinaLiver Unit, Hospital Italiano de Buenos Aires, ArgentinaCMIC Group, Chapelco Clinic, Neuquén, ArgentinaLiver Unit, Hospital Italiano de Buenos Aires, Argentina; Department of Research, Hospital Italiano de Buenos Aires, ArgentinaLiver Unit, Hospital Italiano de Buenos Aires, Argentina; Department of Research, Hospital Italiano de Buenos Aires, Argentina Acute-on-chronic liver failure (ACLF) is one of the main causes of death on the waiting list. Liver transplantation (LT) is the only curative treatment for patients with ACLF and therefore it should be considered in all cases. However, the applicability of LT in patients with ACLF is challenging, given the scarcity of donors and the high short-term mortality of these patients. Organ allocation has traditionally been prioritised according to the model for end-stage liver disease (MELD) system. However, the accuracy of MELD score is limited in patients with ACLF. In this article, the authors review the outcomes of patients with ACLF before and after LT, highlighting its clinical course, the feasibility of LT in the sickest patients, the role of the organ allocation system, and possible indicators of futility.https://www.emjreviews.com/european-medical-journal/article/liver-transplantation-in-patients-with-acute-on-chronic-liver-failure-challenging-the-limits-j190321/ |
| spellingShingle | Juan Manuel Diaz Ezequiel Mauro Maria Nelly Gutierrez-Acevedo Adrian Gadano Sebastian Marciano Liver Transplantation in Patients with Acute-onChronic Liver Failure: Challenging the Limits European Medical Journal |
| title | Liver Transplantation in Patients with Acute-onChronic Liver Failure: Challenging the Limits |
| title_full | Liver Transplantation in Patients with Acute-onChronic Liver Failure: Challenging the Limits |
| title_fullStr | Liver Transplantation in Patients with Acute-onChronic Liver Failure: Challenging the Limits |
| title_full_unstemmed | Liver Transplantation in Patients with Acute-onChronic Liver Failure: Challenging the Limits |
| title_short | Liver Transplantation in Patients with Acute-onChronic Liver Failure: Challenging the Limits |
| title_sort | liver transplantation in patients with acute onchronic liver failure challenging the limits |
| url | https://www.emjreviews.com/european-medical-journal/article/liver-transplantation-in-patients-with-acute-on-chronic-liver-failure-challenging-the-limits-j190321/ |
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