Rad21-cohesin haploinsufficiency impedes DNA repair and enhances gastrointestinal radiosensitivity in mice.

Rad21-cohesin haploinsufficiency impedes DNA repair and enhances gastrointestinal radiosensitivity in mice.

Approximately half of cancer-affected patients receive radiotherapy (RT). The doses delivered have been determined upon empirical experience based upon average radiation responses. Ideally higher curative radiation doses might be employed in patients with genuinely normal radiation responses and imp...

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Bibliographic Details
Main Authors: Huiling Xu, Kuhendra Balakrishnan, Jordane Malaterre, Matthew Beasley, Yuqian Yan, Jeroen Essers, Esther Appeldoorn, Jonathan M Tomaszewski, Melisa Vazquez, Sandra Verschoor, Martin F Lavin, Ivan Bertoncello, Robert G Ramsay, Michael J McKay
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2920816?pdf=render

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