Circulating microRNA‐29‐5p can add to the discrimination between dilated cardiomyopathy and ischaemic heart disease
Abstract Aims Heart failure describes a large and heterogeneous spectrum of underlying cardiac diseases. MicroRNAs (miRs) are small non‐coding RNAs that in recent years have been shown to play an important role in the pathogenesis of heart failure. Cardiac magnetic resonance imaging is a powerful im...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-10-01
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| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.13458 |
| _version_ | 1818738078130372608 |
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| author | Martin Brundin Dick Wågsäter Urban Alehagen Carl‐Johan Carlhäll |
| author_facet | Martin Brundin Dick Wågsäter Urban Alehagen Carl‐Johan Carlhäll |
| author_sort | Martin Brundin |
| collection | DOAJ |
| description | Abstract Aims Heart failure describes a large and heterogeneous spectrum of underlying cardiac diseases. MicroRNAs (miRs) are small non‐coding RNAs that in recent years have been shown to play an important role in the pathogenesis of heart failure. Cardiac magnetic resonance imaging is a powerful imaging modality for the evaluation of cardiac characteristics in heart failure. In this study, we sought to compare heart failure patients with a diagnosis of either idiopathic dilated cardiomyopathy (DCM) or ischaemic heart disease (IHD), in the context of serum levels of certain miRs and also magnetic resonance imaging parameters of cardiac structure and function. Methods and results A total of 135 subjects were studied: 53 patients with DCM (age: 59 ± 12 years, mean ± SD), 34 patients with IHD (66 ± 9 years), and 48 controls (64 ± 5 years). The participants underwent baseline medical examination, blood sampling, and a cardiac magnetic resonance imaging examination at 3 Tesla (Philips Ingenia). The serum levels of seven different miRs were analysed and assessed: 16‐5p, 21‐5p, 29‐5p, 133a‐3p, 191‐5p, 320a, and 423‐5p, all of which have been demonstrated to play potential roles in the pathogenesis of heart failure. The patients in the DCM and IHD groups had left ventricles that had larger end‐diastolic volume (P < 0.001), larger mass (P < 0.001), and lower ejection fraction (P < 0.001) compared with controls. Serum levels of miR‐29‐5p were increased in DCM compared with IHD (P < 0.005) and serum levels of miR‐320a were elevated in DCM compared with healthy controls (P < 0.05). There was no significant association between miR levels and magnetic resonance imaging parameters of left ventricular structure and function. Conclusions Circulating miR‐320a can add to the discrimination between patients with DCM and healthy controls and circulating miR‐29‐5p can add to the discrimination between DCM and IHD. |
| first_indexed | 2024-12-18T01:03:13Z |
| format | Article |
| id | doaj.art-b79fcfcbc5ac468d819993741e740bba |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-12-18T01:03:13Z |
| publishDate | 2021-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-b79fcfcbc5ac468d819993741e740bba2022-12-21T21:26:18ZengWileyESC Heart Failure2055-58222021-10-01853865387410.1002/ehf2.13458Circulating microRNA‐29‐5p can add to the discrimination between dilated cardiomyopathy and ischaemic heart diseaseMartin Brundin0Dick Wågsäter1Urban Alehagen2Carl‐Johan Carlhäll3Department of Clinical Physiology, Department of Health, Medicine and Caring Sciences Linköping University Linköping SwedenDivision of Drug Research, Department of Biomedical and Clinical Sciences Linköping University Linköping SwedenUnit of Cardiovascular Sciences, Department of Health, Medicine and Caring Sciences Linköping University Linköping SwedenDepartment of Clinical Physiology, Department of Health, Medicine and Caring Sciences Linköping University Linköping SwedenAbstract Aims Heart failure describes a large and heterogeneous spectrum of underlying cardiac diseases. MicroRNAs (miRs) are small non‐coding RNAs that in recent years have been shown to play an important role in the pathogenesis of heart failure. Cardiac magnetic resonance imaging is a powerful imaging modality for the evaluation of cardiac characteristics in heart failure. In this study, we sought to compare heart failure patients with a diagnosis of either idiopathic dilated cardiomyopathy (DCM) or ischaemic heart disease (IHD), in the context of serum levels of certain miRs and also magnetic resonance imaging parameters of cardiac structure and function. Methods and results A total of 135 subjects were studied: 53 patients with DCM (age: 59 ± 12 years, mean ± SD), 34 patients with IHD (66 ± 9 years), and 48 controls (64 ± 5 years). The participants underwent baseline medical examination, blood sampling, and a cardiac magnetic resonance imaging examination at 3 Tesla (Philips Ingenia). The serum levels of seven different miRs were analysed and assessed: 16‐5p, 21‐5p, 29‐5p, 133a‐3p, 191‐5p, 320a, and 423‐5p, all of which have been demonstrated to play potential roles in the pathogenesis of heart failure. The patients in the DCM and IHD groups had left ventricles that had larger end‐diastolic volume (P < 0.001), larger mass (P < 0.001), and lower ejection fraction (P < 0.001) compared with controls. Serum levels of miR‐29‐5p were increased in DCM compared with IHD (P < 0.005) and serum levels of miR‐320a were elevated in DCM compared with healthy controls (P < 0.05). There was no significant association between miR levels and magnetic resonance imaging parameters of left ventricular structure and function. Conclusions Circulating miR‐320a can add to the discrimination between patients with DCM and healthy controls and circulating miR‐29‐5p can add to the discrimination between DCM and IHD.https://doi.org/10.1002/ehf2.13458microRNABiomarkerHeart failureCardiomyopathymiRNA‐29‐5pmiRNA‐320a |
| spellingShingle | Martin Brundin Dick Wågsäter Urban Alehagen Carl‐Johan Carlhäll Circulating microRNA‐29‐5p can add to the discrimination between dilated cardiomyopathy and ischaemic heart disease ESC Heart Failure microRNA Biomarker Heart failure Cardiomyopathy miRNA‐29‐5p miRNA‐320a |
| title | Circulating microRNA‐29‐5p can add to the discrimination between dilated cardiomyopathy and ischaemic heart disease |
| title_full | Circulating microRNA‐29‐5p can add to the discrimination between dilated cardiomyopathy and ischaemic heart disease |
| title_fullStr | Circulating microRNA‐29‐5p can add to the discrimination between dilated cardiomyopathy and ischaemic heart disease |
| title_full_unstemmed | Circulating microRNA‐29‐5p can add to the discrimination between dilated cardiomyopathy and ischaemic heart disease |
| title_short | Circulating microRNA‐29‐5p can add to the discrimination between dilated cardiomyopathy and ischaemic heart disease |
| title_sort | circulating microrna 29 5p can add to the discrimination between dilated cardiomyopathy and ischaemic heart disease |
| topic | microRNA Biomarker Heart failure Cardiomyopathy miRNA‐29‐5p miRNA‐320a |
| url | https://doi.org/10.1002/ehf2.13458 |
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